The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing
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Emilio Benfenati | Egon Willighagen | Nina Jeliazkova | Vedrin Jeliazkov | Barry Hardy | Glenn Myatt | Lyn Healy | Glyn Stacey | Scott Miller | Pekka Kohonen | Roland C Grafström | David Bower | Rebecca Ceder | Kevin Cross | Michael Crump | Christoph Helma | Silvia Maggioni | Michael Rautenberg | Jeff Wiseman | G. Myatt | Egon Willighagen | K. Cross | E. Benfenati | C. Helma | P. Kohonen | R. Grafström | M. Crump | G. Stacey | L. Healy | N. Jeliazkova | S. Maggioni | D. Bower | Scott Miller | Jeff Wiseman | R. Ceder | Micha Rautenberg | V. Jeliazkov | B. Hardy | Silvia Maggioni
[1] L. James,et al. Mechanisms of acetaminophen-induced liver necrosis. , 2010, Handbook of experimental pharmacology.
[2] Bing Zhang,et al. WebGestalt: an integrated system for exploring gene sets in various biological contexts , 2005, Nucleic Acids Res..
[3] Matthew S Goldberg,et al. Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection* , 2011, The Journal of Biological Chemistry.
[4] Peter Sartipy,et al. Concise Review: Human Pluripotent Stem Cell‐Based Models for Cardiac and Hepatic Toxicity Assessment , 2011, Stem cells.
[5] David Attwell,et al. A Preferential Role for Glycolysis in Preventing the Anoxic Depolarization of Rat Hippocampal Area CA1 Pyramidal Cells , 2005, The Journal of Neuroscience.
[6] Jürgen Borlak,et al. Drug‐induced phospholipidosis , 2006, FEBS letters.
[7] Arnaud Tonnelier,et al. Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model , 2011, Archives of Toxicology.
[8] Alan R. Boobis,et al. IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans , 2006 .
[9] S. H. Yang,et al. Experimental model of hepatic fibrosis following repeated periportal necrosis induced by allylalcohol. , 2000, Scandinavian journal of gastroenterology.
[10] Olga Tcheremenskaia,et al. Environment and Health , 2004, Frontiers Research Topics.
[11] Smita Jagtap,et al. Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.
[12] Michael S Lajiness,et al. Systems chemical biology and the Semantic Web: what they mean for the future of drug discovery research. , 2012, Drug discovery today.
[13] Tara B. Manion,et al. Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. , 2011, Bioorganic & medicinal chemistry letters.
[14] Michael Balls,et al. Guidance on Good Cell Culture Practice , 2005, Alternatives to laboratory animals : ATLA.
[15] Robert J Kavlock,et al. Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. , 2010, Chemical research in toxicology.
[16] Howard T. Jacobs,et al. Production of Mitochondrial Reactive Oxygen Species Protein in Hypoxia Occurs Independently α Stabilization of Hypoxia-inducible Factor-1 Cell Biology : , 2010 .
[17] J. Williamson. Glycolytic control mechanisms. 3. Effects of iodoacetamide and fluoroacetate on glucose metabolism in the perfused rat heart. , 1967, The Journal of biological chemistry.
[18] L. del Peso,et al. Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. , 2007, Cellular signalling.
[19] Karen Holtzblatt,et al. Rapid Contextual Design: A How-To Guide to Key Techniques for User-Centered Design , 2004, UBIQ.
[20] Melvin E Andersen,et al. A mechanistic redefinition of adverse effects - a key step in the toxicity testing paradigm shift. , 2010, ALTEX.
[21] A. Layton,et al. Liver fibrosis in patients with psoriasis and psoriatic arthritis on long-term, high cumulative dose methotrexate therapy. , 2008, Rheumatology.
[22] Garry R. Buettner,et al. Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide. , 2010, Free radical biology & medicine.
[23] Thomas C. Wiegers,et al. The Comparative Toxicogenomics Database: update 2011 , 2010, Nucleic Acids Res..
[24] Nina Jeliazkova,et al. AMBIT RESTful web services: an implementation of the OpenTox application programming interface , 2011, J. Cheminformatics.
[25] Nigel W. Hardy,et al. Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project , 2008, Nature Biotechnology.
[26] Michael Erb,et al. NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels , 2011, PloS one.
[27] Wendy A. Warr,et al. Scientific workflow systems: Pipeline Pilot and KNIME , 2012, Journal of Computer-Aided Molecular Design.
[28] HoltzblattKaren,et al. Rapid Contextual Design , 2005 .
[29] Imran Shah,et al. Toxicology ontology perspectives. , 2012, ALTEX.
[30] J. Noordhoek,et al. Quinone toxicity in DT-diaphorase-efficient and -deficient colon carcinoma cell lines. , 1999, Biochemical pharmacology.
[31] H. Mehendale,et al. Tissue Repair: An Important Determinant of Final Outcome of Toxicant-Induced Injury , 2005, Toxicologic pathology.
[32] G Babcock,et al. A comparison of apoptosis and necrosis induced by hepatotoxins in HepG2 cells. , 2000, Toxicology and applied pharmacology.
[33] M. Fielden,et al. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. , 2005, Journal of biotechnology.
[34] Thomas C. Wiegers,et al. The Comparative Toxicogenomics Database: update 2013 , 2012, Nucleic Acids Res..
[35] Damian Szklarczyk,et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored , 2010, Nucleic Acids Res..
[36] M. Guenther,et al. Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* , 2001, The Journal of Biological Chemistry.
[37] R. Dringen,et al. Differential Effects of Iodoacetamide and Iodoacetate on Glycolysis and Glutathione Metabolism of Cultured Astrocytes , 2009, Front. Neuroenerg..
[38] P. Seeman,et al. Anti-schizophrenic drugs--membrane receptor sites of action. , 1977, Biochemical pharmacology.
[39] Anne E. Trefethen,et al. Toward interoperable bioscience data , 2012, Nature Genetics.
[40] Imran Shah,et al. A toxicology ontology roadmap. , 2012, ALTEX.
[41] J. Bailar,et al. Toxicity Testing in the 21st Century: A Vision and a Strategy , 2010, Journal of toxicology and environmental health. Part B, Critical reviews.
[42] Yvonne Will,et al. Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays. , 2007, Toxicology in vitro : an international journal published in association with BIBRA.
[43] T. Vanhaecke,et al. Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients , 2012, Archives of Toxicology.
[44] Egon L. Willighagen,et al. Linked open drug data for pharmaceutical research and development , 2011, J. Cheminformatics.
[45] Daniel L Villeneuve,et al. Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment , 2010, Environmental toxicology and chemistry.
[46] P. Wardman,et al. The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: a stopped-flow kinetic study. , 1988, Archives of biochemistry and biophysics.
[47] Jane Synnergren,et al. Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue. , 2012, Physiological genomics.
[48] T. Gant,et al. Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation , 2010, PloS one.
[49] Maurizio Recanatini,et al. Safety of Non-Antiarrhythmic Drugs that Prolong the QT Interval or Induce Torsade de Pointes , 2002, Drug safety.
[50] G. Granneman,et al. The Hepatotoxicity of Valproic Acid and Its Metabolites in Rats. I. Toxicologic, Biochemical and Histopathologic Studies , 1984, Hepatology.
[51] W. Koppenol. Oxygen activation by cytochrome p450: a thermodynamic analysis. , 2007, Journal of the American Chemical Society.
[52] R. McKay,et al. Consensus Guidance for Banking and Supply of Human Embryonic Stem Cell Lines for Research Purposes , 2009, Stem Cell Reviews and Reports.
[53] M Floreani,et al. Metabolism of simple quinones in guinea pig and rat cardiac tissue. , 1995, General pharmacology.
[54] D. Koop,et al. Role of cytochrome P‐450 2E1 in ethanol‐, carbon tetrachloride— and iron‐dependent microsomal lipid peroxidation , 1992, Hepatology.
[55] C. Papadimitriou,et al. The canals of hering might represent a target of methotrexate hepatic toxicity. , 2004, American journal of clinical pathology.
[56] Matthias Hermes,et al. Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration , 2010, Proceedings of the National Academy of Sciences.
[57] J. Castell,et al. Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.
[58] J. Hayes,et al. The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system , 2008, Hepatology.
[59] B. Copple,et al. The Role of Hypoxia-Inducible Factor-1α in Acetaminophen Hepatotoxicity , 2011, Journal of Pharmacology and Experimental Therapeutics.
[60] Kenji Takami,et al. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.
[61] Lawrence J. Marnett,et al. Systems Analysis of Protein Modification and Cellular Responses Induced by Electrophile Stress , 2010, Accounts of chemical research.
[62] H. Overkleeft,et al. Hypersensitive response to over-reactive cysteines. , 2011, Angewandte Chemie.
[63] Shyam Biswal,et al. Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells. , 2002, Toxicology letters.
[64] Paul Jennings,et al. Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies. , 2012, Toxicology in vitro : an international journal published in association with BIBRA.
[65] L. Weber,et al. Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model , 2003, Critical reviews in toxicology.
[66] Barend Mons,et al. Open PHACTS: semantic interoperability for drug discovery. , 2012, Drug discovery today.
[67] L. Weber,et al. Mechanism of Carbon Tetrachloride-Induced Hepatotoxicity. Hepatocellular Damage by Reactive Carbon Tetrachloride Metabolites , 2001, Zeitschrift fur Naturforschung. C, Journal of biosciences.
[68] Kevin M Williams,et al. Reaction of aflatoxin B(1) oxidation products with lysine. , 2002, Chemical research in toxicology.
[69] J. Kremer. Toward a better understanding of methotrexate. , 2004, Arthritis and rheumatism.
[70] Pantelis Sopasakis,et al. Collaborative development of predictive toxicology applications , 2010, J. Cheminformatics.
[71] H. Yamada,et al. The Japanese toxicogenomics project: application of toxicogenomics. , 2010, Molecular nutrition & food research.
[72] Ola Spjuth,et al. Computational toxicology using the OpenTox application programming interface and Bioclipse , 2011, BMC Research Notes.
[73] Richard D Beger,et al. Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate. , 2007, Toxicology and applied pharmacology.
[74] B. Herman,et al. ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition. , 1994, The American journal of physiology.
[75] Jürg Reichen,et al. The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions , 2001, Clinical pharmacology and therapeutics.
[76] Wei Tang. Drug metabolite profiling and elucidation of drug-induced hepatotoxicity , 2007, Expert opinion on drug metabolism & toxicology.
[77] F. Pistollato,et al. Standardization of pluripotent stem cell cultures for toxicity testing , 2012, Expert opinion on drug metabolism & toxicology.