The sarcomeric Z-disc: a nodal point in signalling and disease

[1]  M. Rönty,et al.  Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton. , 2005, Experimental cell research.

[2]  M. Beckerle,et al.  Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. , 2005, The Journal of clinical investigation.

[3]  L. Velloso,et al.  RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes. , 2005, American journal of physiology. Heart and circulatory physiology.

[4]  I. Ferrer,et al.  Myotilinopathy: refining the clinical and myopathological phenotype. , 2005, Brain : a journal of neurology.

[5]  K. Franchini,et al.  Focal adhesion kinase mediates MEF2 and c-Jun activation by stretch: role in the activation of the cardiac hypertrophic genetic program. , 2005, Cardiovascular research.

[6]  E. Kudryashova,et al.  Mdm muscular dystrophy: interactions with calpain 3 and a novel functional role for titin's N2A domain. , 2005, Human molecular genetics.

[7]  A. Sonnenberg,et al.  The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins , 2005, Journal of Cell Science.

[8]  Hanns Lochmüller,et al.  A mutation in the dimerization domain of filamin c causes a novel type of autosomal dominant myofibrillar myopathy. , 2005, American journal of human genetics.

[9]  E. Kudryashova,et al.  Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway. , 2005, Human molecular genetics.

[10]  Christian C Witt,et al.  MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. , 2005, Journal of molecular biology.

[11]  Thomas Sejersen,et al.  The Kinase Domain of Titin Controls Muscle Gene Expression and Protein Turnover , 2005, Science.

[12]  G. Lanfranchi,et al.  Cardiac Overexpression of Melusin Protects From Dilated Cardiomyopathy Due to Long-Standing Pressure Overload , 2005, Circulation research.

[13]  R. Singer,et al.  Promotion of importin α–mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3 , 2005, The Journal of cell biology.

[14]  É. Fernandez,et al.  Calpain 1–titin interactions concentrate calpain 1 in the Z‐band edges and in the N2‐line region within the skeletal myofibril , 2005, The FEBS journal.

[15]  Qiang Zhou,et al.  Dynamics of Z-band based proteins in developing skeletal muscle cells. , 2005, Cell motility and the cytoskeleton.

[16]  G. Dorn,et al.  Protein kinase cascades in the regulation of cardiac hypertrophy. , 2005, The Journal of clinical investigation.

[17]  A. Maturana,et al.  PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists. , 2005, Biochemical and biophysical research communications.

[18]  Andrew G Engel,et al.  Mutations in ZASP define a novel form of muscular dystrophy in humans , 2005, Annals of neurology.

[19]  P. De Camilli,et al.  The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[20]  P. Caroni,et al.  Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  D. Kass,et al.  Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy , 2005, Nature Medicine.

[22]  Holly McDonough,et al.  Muscle ring finger protein-1 inhibits PKCε activation and prevents cardiomyocyte hypertrophy , 2004, The Journal of cell biology.

[23]  Cam Patterson,et al.  Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Masahiko Hoshijima,et al.  Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. , 2004, Journal of the American College of Cardiology.

[25]  J. Kobarg,et al.  Targeting to C-Terminal Myosin Heavy Chain May Explain Mechanotransduction Involving Focal Adhesion Kinase in Cardiac Myocytes , 2004, Circulation research.

[26]  E. Olson,et al.  Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress , 2004, Nature Medicine.

[27]  M. Beckerle,et al.  The LIM domain: from the cytoskeleton to the nucleus , 2004, Nature Reviews Molecular Cell Biology.

[28]  Da-Zhi Wang,et al.  Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. , 2004, The Journal of clinical investigation.

[29]  Se-Jin Lee Regulation of muscle mass by myostatin. , 2004, Annual review of cell and developmental biology.

[30]  R. Ross Molecular and mechanical synergy: cross-talk between integrins and growth factor receptors. , 2004, Cardiovascular research.

[31]  J. Saffitz,et al.  Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  R. Schüle,et al.  The LIM-only Proteins FHL2 and FHL3 Interact with α- and β-Subunits of the Muscle α7β1 Integrin Receptor* , 2004, Journal of Biological Chemistry.

[33]  C. Gregorio,et al.  Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development , 2004, Journal of Cell Science.

[34]  K. Osterziel,et al.  Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and α-actinin and their implication for hypertrophic cardiomyopathy , 2004, Cell and Tissue Research.

[35]  O. Carpén,et al.  Alpha-actinin revisited: a fresh look at an old player. , 2004, Cell motility and the cytoskeleton.

[36]  A. Suzuki,et al.  Affixin interacts with α-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell–substrate interaction , 2004, The Journal of cell biology.

[37]  J. Sanger,et al.  Myofibrillogenesis in skeletal muscle cells in the presence of taxol. , 2004, Cell motility and the cytoskeleton.

[38]  Andrew D McCulloch,et al.  Structural and functional roles of desmin in mouse skeletal muscle during passive deformation. , 2004, Biophysical journal.

[39]  Andrew G Engel,et al.  Mutations in myotilin cause myofibrillar myopathy , 2004, Neurology.

[40]  Qiang Zhou,et al.  A Cypher/ZASP Mutation Associated with Dilated Cardiomyopathy Alters the Binding Affinity to Protein Kinase C* , 2004, Journal of Biological Chemistry.

[41]  W. Pyle,et al.  At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. , 2004, Circulation research.

[42]  H. Granzier,et al.  The giant protein titin: a major player in myocardial mechanics, signaling, and disease. , 2004, Circulation research.

[43]  P. D. de Tombe,et al.  Intracellular Localization and Functional Effects of P21-Activated Kinase-1 (Pak1) in Cardiac Myocytes , 2004, Circulation research.

[44]  R. Schüle,et al.  Extracellular Signal-Regulated Kinase 2 Interacts with and Is Negatively Regulated by the LIM-Only Protein FHL2 in Cardiomyocytes , 2004, Molecular and Cellular Biology.

[45]  G. Taffet,et al.  Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[46]  G. Valle,et al.  Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. , 2003, Journal of the American College of Cardiology.

[47]  N. Bourg,et al.  Calpain 3 Is Activated through Autolysis within the Active Site and Lyses Sarcomeric and Sarcolemmal Components , 2003, Molecular and Cellular Biology.

[48]  É. Fernandez,et al.  The calpain 1–α-actinin interaction , 2003 .

[49]  Susan S. Brown,et al.  Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces α5β1-integrin-dependent myocyte elongation , 2003 .

[50]  E. Olson,et al.  Cardiac hypertrophy: the good, the bad, and the ugly. , 2003, Annual review of physiology.

[51]  C. Deschepper,et al.  Expression of Constitutively Active Guanylate Cyclase in Cardiomyocytes Inhibits the Hypertrophic Effects of Isoproterenol and Aortic Constriction on Mouse Hearts* , 2003, Journal of Biological Chemistry.

[52]  Christian C Witt,et al.  The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. , 2003, Journal of molecular biology.

[53]  A. Samarel,et al.  Activation of focal adhesion kinase by protein kinase Cϵ in neonatal rat ventricular myocytes , 2003 .

[54]  J. Squire,et al.  Heterogeneity of Z-band structure within a single muscle sarcomere: implications for sarcomere assembly. , 2003, Journal of molecular biology.

[55]  R. Schwartz,et al.  Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis. , 2003, Molecular genetics and metabolism.

[56]  Sábata S Constancio,et al.  Focal Adhesion Kinase Is Activated and Mediates the Early Hypertrophic Response to Stretch in Cardiac Myocytes , 2003, Circulation research.

[57]  D. E. Goll,et al.  The calpain system. , 2003, Physiological reviews.

[58]  C. Gregorio,et al.  Nebulin: the nebulous, multifunctional giant of striated muscle. , 2003, Trends in cardiovascular medicine.

[59]  Susan S. Brown,et al.  FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly. , 2003, The Journal of biological chemistry.

[60]  K. Franchini,et al.  Early activation of p160ROCK by pressure overload in rat heart. , 2003, American journal of physiology. Cell physiology.

[61]  Christian C Witt,et al.  The complete mouse nebulin gene sequence and the identification of cardiac nebulin. , 2003, Journal of molecular biology.

[62]  Shun'ichi Kuroda,et al.  A PKCε–ENH–channel complex specifically modulates N-type Ca2+ channels , 2003, Nature Neuroscience.

[63]  D. Buxton,et al.  Induction of Nonmuscle Myosin Heavy Chain II-C by Butyrate in RAW 264.7 Mouse Macrophages* , 2003, The Journal of Biological Chemistry.

[64]  J. Ervasti Costameres: the Achilles' Heel of Herculean Muscle* 210 , 2003, The Journal of Biological Chemistry.

[65]  J. Parsons,et al.  Focal adhesion kinase: the first ten years , 2003, Journal of Cell Science.

[66]  R. Dietz,et al.  Mutations in the Human Muscle LIM Protein Gene in Families With Hypertrophic Cardiomyopathy , 2003, Circulation.

[67]  Attila Kovacs,et al.  The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. , 2003, The Journal of clinical investigation.

[68]  Chengqun Huang,et al.  Characterization and in Vivo Functional Analysis of Splice Variants of Cypher* , 2003, The Journal of Biological Chemistry.

[69]  I. Dikic,et al.  Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. , 2003, The Biochemical journal.

[70]  R. Bloch,et al.  The Hydrophilic Domain of Small Ankyrin-1 Interacts with the Two N-terminal Immunoglobulin Domains of Titin* , 2003, The Journal of Biological Chemistry.

[71]  Vincenzo Sorrentino,et al.  Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles , 2003, The Journal of cell biology.

[72]  M. Lalowski,et al.  Myotilin, the limb-girdle muscular dystrophy 1A (LGMD1A) protein, cross-links actin filaments and controls sarcomere assembly. , 2003, Human molecular genetics.

[73]  M. Beckerle,et al.  Targeted Disruption of the Murine zyxin Gene , 2003, Molecular and Cellular Biology.

[74]  Masahiko Hoshijima,et al.  The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy , 2002, Cell.

[75]  Daniel Auerbach,et al.  Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2 , 2002, Journal of Cell Science.

[76]  Eric Karsenti,et al.  Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein , 2002, Journal of Cell Science.

[77]  P. Backx,et al.  Prevention of Hypertrophy by Overexpression of Kv4.2 in Cultured Neonatal Cardiomyocytes , 2002, Circulation.

[78]  Nathan Christopher Shaner,et al.  Myofibrillogenesis in skeletal muscle cells. , 2002, Clinical orthopaedics and related research.

[79]  J. Metzger,et al.  Myofilament Calcium Sensitivity and Cardiac Disease: Insights From Troponin I Isoforms and Mutants , 2002, Circulation research.

[80]  J. V. Van Eyk,et al.  p21-Activated Kinase Increases the Calcium Sensitivity of Rat Triton-Skinned Cardiac Muscle Fiber Bundles via a Mechanism Potentially Involving Novel Phosphorylation of Troponin I , 2002, Circulation research.

[81]  Leena Peltonen,et al.  Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin. , 2002, American journal of human genetics.

[82]  J. Cooper,et al.  Actin Capping Protein: An Essential Element in Protein Kinase Signaling to the Myofilaments , 2002, Circulation research.

[83]  T. Vallenius,et al.  Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. , 2002, Journal of cell science.

[84]  B. Wilson,et al.  Dual Actions of the G&agr;q Agonist Pasteurella multocida Toxin to Promote Cardiomyocyte Hypertrophy and Enhance Apoptosis Susceptibility , 2002, Circulation research.

[85]  E. Olson,et al.  Calsarcin-3, a Novel Skeletal Muscle-specific Member of the Calsarcin Family, Interacts with Multiple Z-disc Proteins* , 2002, The Journal of Biological Chemistry.

[86]  G. Crabtree,et al.  NFAT Signaling Choreographing the Social Lives of Cells , 2002, Cell.

[87]  J. Molkentin,et al.  Inhibition of Calcineurin and Sarcolemmal Ca2+ Influx Protects Cardiac Morphology and Ventricular Function in Kv4.2N Transgenic Mice , 2002, Circulation.

[88]  R. Weiss,et al.  Targeted Inhibition of Calcineurin in Pressure-overload Cardiac Hypertrophy , 2002, The Journal of Biological Chemistry.

[89]  J. Molkentin,et al.  Impaired cardiac hypertrophic response in Calcineurin Aβ-deficient mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[90]  M. Sheng,et al.  PDZ Domains: Structural Modules for Protein Complex Assembly* , 2002, The Journal of Biological Chemistry.

[91]  A. Bosserhoff,et al.  The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus , 2002, The EMBO journal.

[92]  S. Kudoh,et al.  Integrins Play a Critical Role in Mechanical Stress–Induced p38 MAPK Activation , 2002, Hypertension.

[93]  Robert J. Lefkowitz,et al.  Seven-transmembrane-spanning receptors and heart function , 2002, Nature.

[94]  M. Russell,et al.  Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases. , 2002, Gene.

[95]  E. Olson,et al.  Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[96]  J. Squire,et al.  The three-dimensional structure of a vertebrate wide (slow muscle) Z-band: lessons on Z-band assembly. , 2002, Journal of molecular biology.

[97]  C. Mitchell,et al.  The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin , 2001, The Journal of cell biology.

[98]  Dietmar Labeit,et al.  The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System , 2001 .

[99]  Qiang Zhou,et al.  Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy , 2001, The Journal of cell biology.

[100]  M. Bang,et al.  Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. , 2001, Journal of molecular biology.

[101]  W. Linke,et al.  Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein , 2001, The Journal of cell biology.

[102]  D J Glass,et al.  Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy , 2001, Science.

[103]  A. Marian,et al.  Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes. , 2001, Journal of the American College of Cardiology.

[104]  Yewei Liu,et al.  Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers , 2001, The Journal of cell biology.

[105]  W. Lim,et al.  Mechanism and role of PDZ domains in signaling complex assembly. , 2001, Journal of cell science.

[106]  S. Bockholt,et al.  Targeting of Zyxin to Sites of Actin Membrane Interaction and to the Nucleus* , 2001, The Journal of Biological Chemistry.

[107]  R. Adelstein,et al.  Myosin IIB Is Required for Growth Cone Motility , 2001, The Journal of Neuroscience.

[108]  D. Kass,et al.  Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[109]  F. K. Hamra,et al.  Apparent B-type natriuretic peptide selectivity in the kidney due to differential processing. , 2001, Canadian journal of physiology and pharmacology.

[110]  E. F. Delgado,et al.  Properties of myofibril-bound calpain activity in longissimus muscle of callipyge and normal sheep. , 2001, Journal of animal science.

[111]  Paul Young,et al.  Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly , 2001, The Journal of cell biology.

[112]  Y. Zou,et al.  Isoproterenol Activates Extracellular Signal–Regulated Protein Kinases in Cardiomyocytes Through Calcineurin , 2001, Circulation.

[113]  C. Liew,et al.  A Novel Human Striated Muscle RING Zinc Finger Protein, SMRZ, Interacts with SMT3b via Its RING Domain* , 2001, The Journal of Biological Chemistry.

[114]  Michihiko Yoshida,et al.  A Novel Integrin-Linked Kinase–Binding Protein, Affixin, Is Involved in the Early Stage of Cell–Substrate Interaction , 2001, The Journal of cell biology.

[115]  R. Ross,et al.  Integrins and the myocardium. , 2001, Genetic engineering.

[116]  R. Bassel-Duby,et al.  Cardiac-Specific LIM Protein FHL2 Modifies the Hypertrophic Response to &bgr;-Adrenergic Stimulation , 2001, Circulation.

[117]  J. Leiden,et al.  Phosphorylation of Troponin I by Protein Kinase A Accelerates Relaxation and Crossbridge Cycle Kinetics in Mouse Ventricular Muscle , 2001, Circulation research.

[118]  T. Irving,et al.  Titin-Based Modulation of Calcium Sensitivity of Active Tension in Mouse Skinned Cardiac Myocytes , 2001, Circulation research.

[119]  S. Robia,et al.  Localization and kinetics of protein kinase C-epsilon anchoring in cardiac myocytes. , 2001, Biophysical journal.

[120]  G. Lanfranchi,et al.  Telethonin and Other New Proteins of the Z‐Disc of Skeletal Muscle , 2001, IUBMB life.

[121]  J. Ross,et al.  Adult mice deficient in actinin–associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy , 2001, Nature Medicine.

[122]  M. Bang,et al.  Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies , 2001, The Journal of cell biology.

[123]  Rick B. Vega,et al.  Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[124]  R. Hajjar,et al.  Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[125]  K. Pelin,et al.  Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. , 2001, Journal of molecular biology.

[126]  C. Ponting,et al.  Syncoilin, a Novel Member of the Intermediate Filament Superfamily That Interacts with α-Dystrobrevin in Skeletal Muscle* , 2001, The Journal of Biological Chemistry.

[127]  D. Bredt,et al.  Actinin-Associated LIM Protein-Deficient Mice Maintain Normal Development and Structure of Skeletal Muscle , 2001, Molecular and Cellular Biology.

[128]  J. Seidman,et al.  The Genetic Basis for Cardiomyopathy from Mutation Identification to Mechanistic Paradigms , 2001, Cell.

[129]  L. Kunkel,et al.  Myozenin: An α-actinin- and γ-filamin-binding protein of skeletal muscle Z lines , 2001 .

[130]  J. Strait,et al.  Role of protein kinase C-ε in hypertrophy of cultured neonatal rat ventricular myocytes , 2001 .

[131]  G. Lanfranchi,et al.  FATZ, a Filamin-, Actinin-, and Telethonin-binding Protein of the Z-disc of Skeletal Muscle* , 2000, The Journal of Biological Chemistry.

[132]  E. Olson,et al.  Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[133]  M. Zile,et al.  Integrin Activation and Focal Complex Formation in Cardiac Hypertrophy* , 2000, The Journal of Biological Chemistry.

[134]  P. Sassone-Corsi,et al.  A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM , 2000, Molecular and Cellular Biology.

[135]  A. Matsumori,et al.  Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy , 2000, Human Genetics.

[136]  S. Kempa,et al.  Indications for a Novel Muscular Dystrophy Pathway , 2000, The Journal of cell biology.

[137]  J. Ross,et al.  FHL2 (SLIM3) Is Not Essential for Cardiac Development and Function , 2000, Molecular and Cellular Biology.

[138]  J. Woodgett,et al.  Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy , 2000, The Journal of cell biology.

[139]  M. A. Saad,et al.  Early Activation of the Multicomponent Signaling Complex Associated With Focal Adhesion Kinase Induced by Pressure Overload in the Rat Heart , 2000, Circulation research.

[140]  G. Dorn,et al.  ε Protein Kinase C in Pathological Myocardial Hypertrophy , 2000, The Journal of Biological Chemistry.

[141]  S. Tsui,et al.  Interaction of hCLIM1, an enigma family protein, with α‐actinin 2 , 2000 .

[142]  L. Fananapazir,et al.  Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy. , 2000, Journal of molecular and cellular cardiology.

[143]  J. Gilbert,et al.  Myotilin is mutated in limb girdle muscular dystrophy 1A. , 2000, Human molecular genetics.

[144]  A. Weissman,et al.  RING Finger Proteins Mediators of Ubiquitin Ligase Activity , 2000, Cell.

[145]  E. Olson,et al.  Regulation of Microtubule Dynamics and Myogenic Differentiation by Murf, a Striated Muscle Ring-Finger Protein , 2000, The Journal of cell biology.

[146]  M. Parast,et al.  Characterization of Palladin, a Novel Protein Localized to Stress Fibers and Cell Adhesions , 2000, The Journal of cell biology.

[147]  Qiang Zhou,et al.  Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system , 2000, Mechanisms of Development.

[148]  P. Ping,et al.  Transgenic Overexpression of Constitutively Active Protein Kinase C ε Causes Concentric Cardiac Hypertrophy , 2000 .

[149]  P. Caroni,et al.  Decreased expression of the cardiac LIM domain protein MLP in chronic human heart failure. , 2000, Circulation.

[150]  Naoaki Saito,et al.  ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain. , 2000, Biochemical and biophysical research communications.

[151]  S. Ryu,et al.  Cardiac Phospholipase D2 Localizes to Sarcolemmal Membranes and Is Inhibited by α-Actinin in an ADP-ribosylation Factor-reversible Manner* , 2000, The Journal of Biological Chemistry.

[152]  F. Chapon,et al.  [Familial myopathy with desmin storage seen as a granulo-filamentar, electron-dense material with mutation of the alphaB-cristallin gene]. , 2000, Revue neurologique.

[153]  V. Ferrans,et al.  Nonmuscle myosin II localizes to the Z-lines and intercalated discs of cardiac muscle and to the Z-lines of skeletal muscle. , 2000, Cell motility and the cytoskeleton.

[154]  S. F. Konieczny,et al.  The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin. , 2000, Journal of cell science.

[155]  T. Vallenius,et al.  CLP-36 PDZ-LIM Protein Associates with Nonmuscle α-Actinin-1 and α-Actinin-4* , 2000, The Journal of Biological Chemistry.

[156]  R. Passier,et al.  Oracle, a novel PDZ-LIM domain protein expressed in heart and skeletal muscle , 2000, Mechanisms of Development.

[157]  T. Hewett,et al.  Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. , 2000, The Journal of clinical investigation.

[158]  Rick B. Vega,et al.  A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin Signaling* , 2000, The Journal of Biological Chemistry.

[159]  M. Dalakas,et al.  Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene. , 2000, The New England journal of medicine.

[160]  S. Kawamoto,et al.  Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted mice. , 2000, The Journal of clinical investigation.

[161]  G. Valle,et al.  Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin , 2000, Nature Genetics.

[162]  M. Gautel,et al.  Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation. , 2000, Cell motility and the cytoskeleton.

[163]  P. Luther Three-Dimensional Structure of a Vertebrate Muscle Z-band: Implications for Titin and α-Actinin Binding , 2000 .

[164]  Simon C Watkins,et al.  Filamin 2 (FLN2): A Muscle-specific Sarcoglycan Interacting Protein , 2000 .

[165]  J. Cooper,et al.  Vertebrate Isoforms of Actin Capping Protein β Have Distinct Functions in Vivo , 1999, The Journal of cell biology.

[166]  G. Taffet,et al.  The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function. , 1999, Journal of molecular and cellular cardiology.

[167]  M. Martone,et al.  Chronic Phospholamban–Sarcoplasmic Reticulum Calcium ATPase Interaction Is the Critical Calcium Cycling Defect in Dilated Cardiomyopathy , 1999, Cell.

[168]  D. Mochly‐Rosen,et al.  Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[169]  G. Dorn,et al.  Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation , 1999 .

[170]  M. Vidal,et al.  Identification of a family of human F-box proteins , 1999, Current Biology.

[171]  L. Silengo,et al.  Melusin Is a New Muscle-specific Interactor for β1Integrin Cytoplasmic Domain* , 1999, The Journal of Biological Chemistry.

[172]  J. Levine,et al.  A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice , 1999, Neuron.

[173]  P. Burch,et al.  Desmin mutation responsible for idiopathic dilated cardiomyopathy. , 1999, Circulation.

[174]  G. Lanfranchi,et al.  ZASP: a new Z-band alternatively spliced PDZ-motif protein. , 1999, The Journal of cell biology.

[175]  Qiang Zhou,et al.  Cypher, a Striated Muscle-restricted PDZ and LIM Domain-containing Protein, Binds to α-Actinin-2 and Protein Kinase C* , 1999, The Journal of Biological Chemistry.

[176]  J. Kere,et al.  Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy. , 1999, Human molecular genetics.

[177]  G. Gill,et al.  The PDZ Domain of the LIM Protein Enigma Binds to β-Tropomyosin , 1999 .

[178]  T. Rabbitts,et al.  Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1. , 1999, Gene.

[179]  Y. Yazaki,et al.  Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. , 1999, Biochemical and biophysical research communications.

[180]  A. Børglum,et al.  α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy , 1999 .

[181]  J. Corbin,et al.  Cyclic GMP Phosphodiesterase-5: Target of Sildenafil* , 1999, The Journal of Biological Chemistry.

[182]  J. Beckmann,et al.  Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBα/NF-κB pathway in limb-girdle muscular dystrophy type 2A , 1999, Nature Medicine.

[183]  C. Biben,et al.  The cardiac expression of striated muscle LIM protein 1 (SLIM1) is restricted to the outflow tract of the developing heart. , 1999, Journal of molecular and cellular cardiology.

[184]  S. Easteal,et al.  A common nonsense mutation results in α-actinin-3 deficiency in the general population , 1999, Nature Genetics.

[185]  F. Raynaud,et al.  Alpha actinin–CapZ, an anchoring complex for thin filaments in Z-line , 1999, Journal of Muscle Research & Cell Motility.

[186]  K. Oegema,et al.  Cytokinesis in eukaryotes: a mechanistic comparison. , 1999, Current opinion in cell biology.

[187]  K P Fung,et al.  Characterization of the human 36‐kDa carboxyl terminal LIM domain protein (hCLIM1) , 1999, Journal of cellular biochemistry.

[188]  Siegfried Labeit,et al.  The NH2 Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity , 1998, The Journal of cell biology.

[189]  Paul Young,et al.  Structural basis for activation of the titin kinase domain during myofibrillogenesis , 1998, Nature.

[190]  C. Fyrberg,et al.  Characterization of Lethal Drosophila melanogaster alpha-Actinin Mutants , 1998, Biochemical Genetics.

[191]  K. Campbell,et al.  The sarcoglycan complex in limb-girdle muscular dystrophy. , 1998, Current opinion in neurology.

[192]  J. Mate,et al.  A dysfunctional desmin mutation in a patient with severe generalized myopathy. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[193]  K. Pelin,et al.  Characterization of nebulette and nebulin and emerging concepts of their roles for vertebrate Z-discs. , 1998, Journal of molecular biology.

[194]  J. Beckmann,et al.  A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B , 1998, Nature Genetics.

[195]  J. Nagle,et al.  Missense mutations in desmin associated with familial cardiac and skeletal myopathy , 1998, Nature Genetics.

[196]  S. Snyder,et al.  Cain, A Novel Physiologic Protein Inhibitor of Calcineurin* , 1998, The Journal of Biological Chemistry.

[197]  I. Ohtsuki,et al.  Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy. , 1998, American journal of physiology. Cell physiology.

[198]  H. Youn,et al.  Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. , 1998, Immunity.

[199]  M. Gautel,et al.  Two immunoglobulin‐like domains of the Z‐disc portion of titin interact in a conformation‐dependent way with telethonin , 1998, FEBS letters.

[200]  Jeffrey Robbins,et al.  A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy , 1998, Cell.

[201]  S. Shattil,et al.  Integrin signaling: the platelet paradigm. , 1998, Blood.

[202]  Siegfried Labeit,et al.  Titin Extensibility In Situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments , 1998, The Journal of cell biology.

[203]  V. Ferrans,et al.  Nonmuscle myosin II-B is required for normal development of the mouse heart. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[204]  H. A. Louis,et al.  Comparison of Three Members of the Cysteine-rich Protein Family Reveals Functional Conservation and Divergent Patterns of Gene Expression* , 1997, The Journal of Biological Chemistry.

[205]  W. Kuo,et al.  Actinin-associated LIM Protein: Identification of a Domain Interaction between PDZ and Spectrin-like Repeat Motifs , 1997, The Journal of cell biology.

[206]  Mike Tyers,et al.  F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex , 1997, Cell.

[207]  G. Butler-Browne,et al.  Desmin Is Essential for the Tensile Strength and Integrity of Myofibrils but Not for Myogenic Commitment, Differentiation, and Fusion of Skeletal Muscle , 1997, The Journal of cell biology.

[208]  H. Granzier,et al.  Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction. , 1997, Biophysical journal.

[209]  G. Lanfranchi,et al.  Telethonin, a novel sarcomeric protein of heart and skeletal muscle , 1997, FEBS letters.

[210]  David A. Nix,et al.  Nuclear–Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus , 1997, The Journal of cell biology.

[211]  A. Chien,et al.  Identification and Subcellular Localization of the Subunits of L-type Calcium Channels and Adenylyl Cyclase in Cardiac Myocytes* , 1997, The Journal of Biological Chemistry.

[212]  S. F. Konieczny,et al.  Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD , 1997, Molecular and cellular biology.

[213]  G. Dorn,et al.  Transgenic Gαq overexpression induces cardiac contractile failure in mice , 1997 .

[214]  M. Greaser,et al.  Arachidonic acid stimulates protein kinase C-epsilon redistribution in heart cells. , 1997, Journal of cell science.

[215]  E. Golemis,et al.  ArgBP2, a Multiple Src Homology 3 Domain-containing, Arg/Abl-interacting Protein, Is Phosphorylated in v-Abl-transformed Cells and Localized in Stress Fibers and Cardiocyte Z-disks* , 1997, The Journal of Biological Chemistry.

[216]  S. Pawlowski,et al.  Rescue of cardiac α-actin-deficient mice by enteric smooth muscle γ-actin , 1997 .

[217]  S. Grinstein,et al.  Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion , 1997, Nature.

[218]  B. Schäfer,et al.  Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma. , 1997, DNA and cell biology.

[219]  W. Mckenna,et al.  The management of hypertrophic cardiomyopathy. , 1997, The New England journal of medicine.

[220]  Y. Ono,et al.  Interaction of PKN with α-Actinin* , 1997, The Journal of Biological Chemistry.

[221]  Y. Zou,et al.  CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. , 1997, Development.

[222]  Minoru Hongo,et al.  MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure , 1997, Cell.

[223]  R L Lieber,et al.  12 Force Transmission in Skeletal Muscle: from Actomyosin to External Tendons , 1997, Exercise and sport sciences reviews.

[224]  T. Macalma,et al.  Molecular Characterization of Human Zyxin* , 1996, The Journal of Biological Chemistry.

[225]  Kensaku Mizuno,et al.  Protein-Protein Interaction of Zinc Finger LIM Domains with Protein Kinase C* , 1996, The Journal of Biological Chemistry.

[226]  M. Gautel,et al.  The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers. , 1996, Journal of cell science.

[227]  R. Schwartz,et al.  Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription , 1996, Molecular and cellular biology.

[228]  Jonathan A. Cooper,et al.  Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides , 1996, The Journal of cell biology.

[229]  M. Gautel,et al.  The structure of the sarcomeric M band: localization of defined domains of myomesin, M-protein, and the 250-kD carboxy-terminal region of titin by immunoelectron microscopy , 1996, The Journal of cell biology.

[230]  Y. Capetanaki,et al.  Disruption of muscle architecture and myocardial degeneration in mice lacking desmin , 1996, The Journal of cell biology.

[231]  M. Morgan,et al.  Slim defines a novel family of LIM-proteins expressed in skeletal muscle. , 1996, Biochemical and biophysical research communications.

[232]  S. Taylor,et al.  Specificity of LIM Domain Interactions with Receptor Tyrosine Kinases* , 1996, The Journal of Biological Chemistry.

[233]  J. Chant,et al.  Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway , 1996, Current Biology.

[234]  S. Dedhar,et al.  Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase , 1996, Nature.

[235]  A. Newton,et al.  Protein Kinase C: Structure, Function, and Regulation (*) , 1995, The Journal of Biological Chemistry.

[236]  J. Parsons,et al.  Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains , 1995, The Journal of cell biology.

[237]  Isabelle Richard,et al.  Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A , 1995, Cell.

[238]  L. Langeberg,et al.  Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. , 1995, Science.

[239]  Jonathan A. Cooper,et al.  Inhibition of CapZ during myofibrillogenesis alters assembly of actin filaments , 1995, The Journal of cell biology.

[240]  S. Bishop,et al.  Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat. , 1994, Circulation research.

[241]  P. Caroni,et al.  Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation , 1994, Cell.

[242]  M. Beckerle,et al.  The LIM domain is a modular protein-binding interface , 1994, Cell.

[243]  Jonathan A. Cooper,et al.  Differential localization and sequence analysis of capping protein beta- subunit isoforms of vertebrates , 1994, The Journal of cell biology.

[244]  M. Disatnik,et al.  Localization of protein kinase C isozymes in cardiac myocytes. , 1994, Experimental cell research.

[245]  M. Becker‐André,et al.  Expression of an N-terminally truncated form of human focal adhesion kinase in brain. , 1993, Biochemical and biophysical research communications.

[246]  S. Hanks,et al.  Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[247]  G. M. Dmytrenko,et al.  Dystrophin colocalizes with beta-spectrin in distinct subsarcolemmal domains in mammalian skeletal muscle , 1992, The Journal of cell biology.

[248]  J. Parsons,et al.  pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[249]  M. Beckerle,et al.  An interaction between zyxin and alpha-actinin , 1992, The Journal of cell biology.

[250]  B. Finlay,et al.  In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. , 1991, Biochemistry.

[251]  K. Wang,et al.  Nebulin as a length regulator of thin filaments of vertebrate skeletal muscles: correlation of thin filament length, nebulin size, and epitope profile , 1991, The Journal of cell biology.

[252]  P. Luther Three-dimensional reconstruction of a simple Z-band in fish muscle , 1991, The Journal of cell biology.

[253]  L. Edström,et al.  Myopathy with respiratory failure and typical myofibrillar lesions , 1990, Journal of the Neurological Sciences.

[254]  A. Noegel,et al.  The Dictyostelium gelation factor shares a putative actin binding site with alpha-actinins and dystrophin and also has a rod domain containing six 100-residue motifs that appear to have a cross-beta conformation , 1989, The Journal of cell biology.

[255]  Eric P. Hoffman,et al.  Dystrophin: The protein product of the duchenne muscular dystrophy locus , 1987, Cell.

[256]  G. Blobel,et al.  Binding of two desmin derivatives to the plasma membrane and the nuclear envelope of avian erythrocytes: evidence for a conserved site-specificity in intermediate filament-membrane interactions. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[257]  J. Sanger,et al.  Myofibrillogenesis in living cells microinjected with fluorescently labeled alpha-actinin , 1986, The Journal of cell biology.

[258]  J. Vandekerckhove,et al.  Simultaneous expression of skeletal muscle and heart actin proteins in various striated muscle tissues and cells. A quantitative determination of the two actin isoforms. , 1986, The Journal of biological chemistry.

[259]  M. Yamaguchi,et al.  Fine structure of wide and narrow vertebrate muscle Z-lines. A proposed model and computer simulation of Z-line architecture. , 1985, Journal of molecular biology.

[260]  J. Siliciano,et al.  A vinculin-containing cortical lattice in skeletal muscle: transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemma. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[261]  J. Potter,et al.  The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin. , 1982, The Journal of biological chemistry.

[262]  B. L. Granger,et al.  Synemin: a new high molecular weight protein associated with desmin and vimentin filaments in muscle , 1980, Cell.

[263]  J. Small,et al.  Studies on the function and composition of the 10-NM(100-A) filaments of vertebrate smooth muscle. , 1977, Journal of cell science.

[264]  E. Lazarides,et al.  Immunological characterization of the subunit of the 100 A filaments from muscle cells. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[265]  D. E. Goll,et al.  Studies on purified -actinin. II. Electron microscopic studies on the competitive binding of -actinin and tropomyosin to Z-line extracted myofibrils. , 1972, Journal of molecular biology.

[266]  D. E. Goll,et al.  Studies on purified -actinin. I. Effect of temperature and tropomyosin on the -actinin-F-actin interaction. , 1972, Journal of molecular biology.

[267]  D. E. Goll,et al.  Purification and properties of α-actinin from rabbit skeletal muscle☆ , 1970 .

[268]  Luigi Fratta,et al.  Melusin, a muscle-specific integrin β1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload , 2003, Nature Medicine.

[269]  M. Beckerle,et al.  Striated muscle cytoarchitecture: an intricate web of form and function. , 2002, Annual review of cell and developmental biology.

[270]  M. Bang,et al.  Molecular dissection of the interaction of desmin with the C-terminal region of nebulin. , 2002, Journal of structural biology.

[271]  Alan Wells,et al.  Cutting to the chase: calpain proteases in cell motility. , 2002, Trends in cell biology.

[272]  S. Vatner,et al.  Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes. , 2001, The Journal of biological chemistry.

[273]  M. Waye,et al.  Elfin is expressed during early heart development * , 2001, Journal of cellular biochemistry.

[274]  R. Lefkowitz,et al.  alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. , 2000, FEBS letters.

[275]  B. Kolmerer,et al.  The complete primary structure of human nebulin and its correlation to muscle structure. , 1995, Journal of molecular biology.

[276]  C. Moncman,et al.  Nebulette: a 107 kD nebulin-like protein in cardiac muscle. , 1995, Cell motility and the cytoskeleton.

[277]  U. Bengtsson,et al.  Efforts toward understanding the molecular basis of facioscapulohumeral muscular dystrophy , 1995, Muscle & nerve. Supplement.

[278]  J. Sanger,et al.  The premyofibril: evidence for its role in myofibrillogenesis. , 1994, Cell motility and the cytoskeleton.

[279]  C. M. Cohen,et al.  Cell type-specific association between two types of spectrin and two types of intermediate filaments. , 1987, Cell motility and the cytoskeleton.

[280]  M. McKenna,et al.  Filamentous structures morphologically similar to viral nucleocapsids in otosclerotic lesions in two patients. , 1986, The American journal of otology.