Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial

[1]  D. Rader,et al.  Statins and Cognitive Function: A Systematic Review†∗ , 2014 .

[2]  Graham R. Gibbs,et al.  Analyzing Qualitative Data , 2014 .

[3]  T. Johnson,et al.  Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial , 2012, The Lancet.

[4]  K. Nakashima,et al.  [The Rotterdam study]. , 2011, Nihon rinsho. Japanese journal of clinical medicine.

[5]  C. Brayne,et al.  What do we mean by Alzheimer’s disease? , 2010, BMJ : British Medical Journal.

[6]  L. Ferrucci,et al.  Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment , 2010, Journal of Epidemiology & Community Health.

[7]  Sterling C. Johnson,et al.  A randomized, double-blind placebo-controlled trial of simvastatin on CSF, MRI, and cognitive biomarkers in middle-aged adults at risk for Alzheimer's disease: The ESPRIT Study , 2010, Alzheimer's & Dementia.

[8]  G. Schellenberg,et al.  Age‐Varying Association Between Statin Use and Incident Alzheimer's Disease , 2010, Journal of the American Geriatrics Society.

[9]  Jonathan J. Evans,et al.  Adaptation and validation of the Tower of London test of planning and problem solving in people with intellectual disabilities. , 2010, Journal of intellectual disability research : JIDR.

[10]  C. Gasse,et al.  Use of Statins and Risk of Hospitalization With Dementia: A Danish Population-based Case-control Study , 2009, Alzheimer disease and associated disorders.

[11]  A. Arshad,et al.  STATINS, INCIDENT ALZHEIMER DISEASE, CHANGE IN COGNITIVE FUNCTION, AND NEUROPATHOLOGY , 2008, Neurology.

[12]  A Hofman,et al.  Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[13]  W. Silverman,et al.  Selective attention deficits associated with mild cognitive impairment and early stage Alzheimer's disease in adults with Down syndrome. , 2008, American journal of mental retardation : AJMR.

[14]  J D Kalbfleisch,et al.  Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study , 2008, Neurology.

[15]  S. Feasson,et al.  MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20536 high-risk individuals : a randomised placebo-controlled trial. , 2008 .

[16]  W. Silverman,et al.  Maladaptive behaviors related to dementia status in adults with Down syndrome. , 2008, American journal of mental retardation : AJMR.

[17]  F. Huppert,et al.  Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer's disease in adults with Down syndrome and mild to moderate learning disabilities. , 2008, The British journal of clinical psychology.

[18]  Victoria J. Bourne,et al.  n–3 Fatty acid erythrocyte membrane content, APOE ε4, and cognitive variation: an observational follow-up study in late adulthood , 2008 .

[19]  Nirmal Singh,et al.  Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil , 2008, Journal of psychopharmacology.

[20]  C. Wolfson,et al.  Lipid-Lowering Agents and the Risk of Cognitive Impairment That Does Not Meet Criteria for Dementia, in Relation to Apolipoprotein E Status , 2007, Neuroepidemiology.

[21]  P. Macfarlane,et al.  Association Between Apolipoprotein E4 and Cognitive Decline in Elderly Adults , 2007, Journal of the American Geriatrics Society.

[22]  R. Karas,et al.  Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials. , 2007, Journal of the American College of Cardiology.

[23]  B. Tycko,et al.  Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome , 2007, Neuroscience Letters.

[24]  T. Willnow,et al.  Lipoprotein receptors in Alzheimer's disease , 2006, Trends in Neurosciences.

[25]  K. Fukuchi,et al.  Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice , 2006, Neurobiology of Aging.

[26]  K. Hall,et al.  International Studies in Dementia With Particular Emphasis on Populations of African Origin , 2006, Alzheimer disease and associated disorders.

[27]  F. Huppert,et al.  Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population‐based study , 2006, International journal of geriatric psychiatry.

[28]  N. Baheti,et al.  Effects of atorvastatin on higher functions , 2006, European Journal of Clinical Pharmacology.

[29]  L. Kuller,et al.  Statins and cognitive function in the elderly , 2005, Neurology.

[30]  P. Doraiswamy,et al.  Statins and Cognition: What Can We Learn from Existing Randomized Trials? , 2005, CNS Spectrums.

[31]  Lewis H Kuller,et al.  Statin use and the risk of incident dementia: the Cardiovascular Health Study. , 2005, Archives of neurology.

[32]  J. Dartigues,et al.  APOE genotype, cholesterol level, lipid-lowering treatment, and dementia , 2005, Neurology.

[33]  V. Prasher,et al.  Rivastigmine in the treatment of dementia in Alzheimer's disease in adults with Down syndrome , 2005, International journal of geriatric psychiatry.

[34]  Patrick Browne,et al.  Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. , 2005, Archives of neurology.

[35]  N. Lennox,et al.  Beating the barriers: recruitment of people with intellectual disability to participate in research. , 2005, Journal of intellectual disability research : JIDR.

[36]  D. Sparks,et al.  Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. , 2005, Archives of general psychiatry.

[37]  I. Deary,et al.  Life long changes in cognitive ability are associated with prescribed medications in old age , 2004, International journal of geriatric psychiatry.

[38]  H. Dodge,et al.  Use of Lipid‐Lowering Drugs in Older Adults With and Without Dementia: A Community‐Based Epidemiological Study , 2002, Journal of the American Geriatrics Society.

[39]  L. Spencer,et al.  Qualitative data analysis for applied policy research , 2002 .

[40]  J. Dichgans,et al.  Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26‐week randomized, placebo‐controlled, double‐blind trial , 2002, Annals of neurology.

[41]  Caroline Hayward,et al.  Ageing: Cognitive change and the APOE ɛ4 allele , 2002, Nature.

[42]  Arto Mannermaa,et al.  Apolipoprotein E 4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease , 2002, Annals of Internal Medicine.

[43]  S. Cooray,et al.  Difficulties in conducting a randomized controlled trial of health service interventions in intellectual disability: implications for evidence-based practice. , 2002, Journal of intellectual disability research : JIDR.

[44]  E. Barrett-Connor,et al.  Serum lipoprotein levels, statin use, and cognitive function in older women. , 2002, Archives of neurology.

[45]  V. Prasher,et al.  A 24‐week, double‐blind, placebo‐controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease—pilot study , 2002, International journal of geriatric psychiatry.

[46]  Simon Lovestone,et al.  Alzheimer's disease – do tauists and baptists finally shake hands? , 2002, Trends in Neurosciences.

[47]  F. Huppert,et al.  Incidence and course of dementia in people with Down's syndrome: findings from a population-based study. , 2001, Journal of intellectual disability research : JIDR.

[48]  I. Hamilton-Craig,et al.  Statin‐associated myopathy , 2001, The Medical journal of Australia.

[49]  S. DeKosky,et al.  Incidence of Alzheimer’s disease in a rural community in India , 2001, Neurology.

[50]  B. Golomb,et al.  Statins and dementia. , 2001, Archives of neurology.

[51]  C. Schweiger.  [Statins and the risk of dementia]. , 2001, Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology.

[52]  S. Krinsky-McHale,et al.  Sequence of cognitive decline in dementia in adults with Down's syndrome. , 2000, Journal of intellectual disability research : JIDR.

[53]  G. Celesia,et al.  Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. , 2000, Archives of neurology.

[54]  F. Huppert,et al.  Neuropsychological assessment of older adults with Down's syndrome: an epidemiological study using the Cambridge Cognitive Examination (CAMCOG). , 1999, The British journal of clinical psychology.

[55]  A. Holland,et al.  A four year prospective study of age-related cognitive change in adults with Down's syndrome , 1998, Psychological Medicine.

[56]  G C Roman,et al.  Brain infarction and the clinical expression of Alzheimer disease. , 1997, JAMA.

[57]  W. Markesbery,et al.  Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. , 1997, JAMA.

[58]  E M Wijsman,et al.  Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease , 1995, Neurology.

[59]  V. Prasher.  Age‐specific prevalence, thyroid dysfunction and depressive symptomatology in adults with down syndrome and dementia , 1995 .

[60]  T. Robbins.  Cambridge Neuropsychological Test Automated Battery (CANTAB): utility and validation , 1994 .

[61]  T. Terasaki,et al.  Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier. , 1993, The Journal of pharmacology and experimental therapeutics.

[62]  T. Nikkari,et al.  Down's syndrome and atherosclerosis. , 1989, Atherosclerosis.

[63]  David M. A. Mann,et al.  The pathological association between down syndrome and Alzheimer disease , 1988, Mechanisms of Ageing and Development.

[64]  P. Townsend,et al.  Health and Deprivation: Inequality and the North , 1987 .

[65]  C. Fletcher,et al.  Down's syndrome: an atheroma-free model? , 1977, British medical journal.

[66]  김의영,et al.  한국인 신경인지기능 평가를 위한 Cambridge Neuropsychological Test Automated Battery(CANTAB)의 신뢰성 평가 , 2012 .

[67]  Frank Sullivan,et al.  Strategies to improve recruitment to randomised controlled trials. , 2010, The Cochrane database of systematic reviews.

[68]  P. Passmore,et al.  Statins for the prevention of dementia. , 2009, The Cochrane database of systematic reviews.

[69]  S. Krinsky-McHale,et al.  The Cued Recall Test: Detection of Memory Impairment , 2009 .

[70]  Sterling C. Johnson,et al.  Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease. , 2008, Journal of Alzheimer's disease : JAD.

[71]  R. Mayeux,et al.  Incident Dementia, and Mortality in Down Syndrome , 2007 .

[72]  Trials BioMed Central , 2006 .

[73]  S. Yusuf.  MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Commentary , 2002 .

[74]  J. Kleijnen,et al.  General health status measures for people with cognitive impairment: learning disability and acquired brain injury. , 2001, Health technology assessment.

[75]  M. Knapp.  Economic Evaluation of Mental Health Care , 2001 .

[76]  S. O’Meara,et al.  A rapid and systematic review of the clinical effectiveness and cost-effectiveness of orlistat in the management of obesity. , 2001, Health technology assessment.

[77]  P. Mehta,et al.  Cognitive changes in memory precede those in praxis in aging persons with Down syndrome , 1999 .

[78]  K. Ashwell,et al.  An in vitro study of the effects of lovastatin on human fetal brain cells. , 1995, Neurotoxicology and teratology.

[79]  J. Beecham.  Collecting and estimating costs , 1995 .

[80]  Martin Knapp,et al.  Costing psychiatric interventions. , 1992 .

[81]  C. Brewin,et al.  Measuring mental health needs , 1992 .

[82]  F. Aldrich,et al.  The Rivermead behavioural memory test for children (RBMT-C) , 1991 .

[83]  Paul D. Williams,et al.  A user's guide to the General Health Questionnaire , 1988 .