Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles.

[1]  P. Carrupt,et al.  Zebrafish bioassay-guided isolation of antiseizure compounds from the Cameroonian medicinal plant Cyperus articulatus L. , 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[2]  Simon Rogers,et al.  Feature-Based Molecular Networking in the GNPS Analysis Environment , 2019, Nature Methods.

[3]  Jonathan Bisson,et al.  Taxonomically Informed Scoring Enhances Confidence in Natural Products Annotation , 2019, bioRxiv.

[4]  D. Lazari,et al.  Chemical constituents isolated from the rhizomes of Helleborus odorus subsp. cyclophyllus (Ranunculaceae) , 2018, Biochemical Systematics and Ecology.

[5]  M. A. Maieron.  On the hellebore trail: an anthropological research into madness , 2018 .

[6]  L. Marcourt,et al.  Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi , 2018, PloS one.

[7]  L. Bennet,et al.  Ganaxolone: A New Treatment for Neonatal Seizures , 2017, Front. Cell. Neurosci..

[8]  Shuzhao Li,et al.  One Step Forward for Reducing False Positive and False Negative Compound Identifications from Mass Spectrometry Metabolomics Data: New Algorithms for Constructing Extracted Ion Chromatograms and Detecting Chromatographic Peaks. , 2017, Analytical chemistry.

[9]  H. Poulsen,et al.  The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease , 2017, Front. Physiol..

[10]  A. J. Kesel,et al.  Pharmacology and psychiatry at the origins of Greek medicine: The myth of Melampus and the madness of the Proetides , 2017, Journal of the history of the neurosciences.

[11]  Xiumei Gao,et al.  New minor spirostanol glycosides from Helleborus thibetanus , 2017, Natural product research.

[12]  P. Burth,et al.  Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy , 2017, Molecules.

[13]  Seema Patel.  Plant-derived cardiac glycosides: Role in heart ailments and cancer management. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  A. Strid,et al.  Vascular plants of Greece: An annotated checklist. Supplement , 2016, Willdenowia.

[15]  Kristian Fog Nielsen,et al.  Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking , 2016, Nature Biotechnology.

[16]  A. Coppola,et al.  The challenges of treating epilepsy with 25 antiepileptic drugs. , 2016, Pharmacological research.

[17]  Jonathan Bisson,et al.  Integration of Molecular Networking and In-Silico MS/MS Fragmentation for Natural Products Dereplication. , 2016, Analytical chemistry.

[18]  Hui Zhang,et al.  Three new steroidal saponins from Helleborus thibetanus , 2016, Natural product research.

[19]  Abigail R. Colson,et al.  Health and economic benefits of public financing of epilepsy treatment in India: An agent‐based simulation model , 2016, Epilepsia.

[20]  P. Gerbaux,et al.  Effects of Holothuroid Ichtyotoxic Saponins on the Gills of Free-Living Fishes and Symbiotic Pearlfishes , 2015, The Biological Bulletin.

[21]  D. Guillarme,et al.  Rational and Efficient Preparative Isolation of Natural Products by MPLC-UV-ELSD based on HPLC to MPLC Gradient Transfer , 2015, Planta Medica.

[22]  H. Lerche,et al.  Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum. , 2014, ACS chemical neuroscience.

[23]  Stefan R. Pulver,et al.  Ultra-sensitive fluorescent proteins for imaging neuronal activity , 2013, Nature.

[24]  W. Berger,et al.  Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase , 2013, Molecular Cancer.

[25]  Peter A. M. de Witte,et al.  Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs , 2013, PloS one.

[26]  C. Dobrotă,et al.  Natural compounds with important medical potential found in Helleborus sp. , 2013, Central European Journal of Biology.

[27]  S. Kanji,et al.  Cardiac glycoside toxicity: more than 200 years and counting. , 2012, Critical care clinics.

[28]  Natalie I. Tasman,et al.  A Cross-platform Toolkit for Mass Spectrometry and Proteomics , 2012, Nature Biotechnology.

[29]  A. Crawford,et al.  Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models , 2012, Epilepsy & Behavior.

[30]  A. Napolitano,et al.  Caucasicosides E-M, furostanol glycosides from Helleborus caucasicus. , 2011, Phytochemistry.

[31]  A. Steinkasserer,et al.  MCS-18, a novel natural plant product prevents autoimmune diabetes. , 2011, Immunology letters.

[32]  F. Kerek,et al.  The antioxidant effects of some progressively purified fractions from Helleborus purpurascens , 2011 .

[33]  Wei Sun,et al.  Two new bufadienolides from the rhizomes of Helleborus thibetanus Franch. , 2010, Fitoterapia.

[34]  Matej Oresic,et al.  MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data , 2010, BMC Bioinformatics.

[35]  H. Sakagami,et al.  Furostanol glycosides from the rhizomes of Helleborus orientalis , 2010, Journal of Natural Medicines.

[36]  M. Avoli,et al.  Neurosteroids and epilepsy , 2010, Current opinion in neurology.

[37]  Emmanouil Magiorkinis,et al.  Hallmarks in the history of epilepsy: Epilepsy in antiquity , 2010, Epilepsy & Behavior.

[38]  Christian Bottomley,et al.  Estimation of the burden of active and life-time epilepsy: A meta-analytic approach , 2010, Epilepsia.

[39]  N. Gomes,et al.  Plants with neurobiological activity as potential targets for drug discovery , 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[40]  S. Rosselli,et al.  Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius , 2009, Phytotherapy research : PTR.

[41]  R. Acquaviva,et al.  Antibacterial activity of Helleborus bocconei Ten. subsp. siculus root extracts. , 2009, Journal of ethnopharmacology.

[42]  Shiyou Li,et al.  Ecdysteroids and a sucrose phenylpropanoid ester from Froelichia floridana. , 2009, Phytochemistry.

[43]  Laurence Marie Victoria Totelin,et al.  Hippocratic Recipes: Oral and Written Transmission of Pharmacological Knowledge in Fifth- And Fourth-Century Greece , 2008 .

[44]  Alexander D Crawford,et al.  Fishing for Drugs from Nature: Zebrafish as a Technology Platform for Natural Product Discovery , 2008, Planta medica.

[45]  S. Piacente,et al.  Steroidal glycosides from the underground parts of Helleborus caucasicus. , 2008, Phytochemistry.

[46]  L. Ren,et al.  Antidepressant activity of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae). , 2007, Die Pharmazie.

[47]  M. Thomas,et al.  Cardiac glycosides provide neuroprotection against ischemic stroke: Discovery by a brain slice-based compound screening platform , 2006, Proceedings of the National Academy of Sciences.

[48]  X. Yao,et al.  Novel furostanol saponins from the bulbs of Allium macrostemon B. and their bioactivity on [Ca2+]i increase induced by KCl , 2006, Journal of Asian natural products research.

[49]  H. Sakagami,et al.  Four New Steroidal Saponins from the Rhizomes of Helleborus orientalis , 2005 .

[50]  P. Kintya,et al.  Steroid saponins. XIII. The structure of alliumosides D and E fromAllium narcissiflorum , 1976, Chemistry of Natural Compounds.

[51]  Da-yuan Zhu,et al.  Terrestrinins A and B, two new steroid saponins from Tribulus terrestris , 2003, Journal of Asian natural products research.

[52]  E. Kuepeli,et al.  Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. , 2003, Journal of ethnopharmacology.

[53]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[54]  H. Sakagami,et al.  Bufadienolide and spirostanol glycosides from the rhizomes of helleborusorientalis. , 2003, Journal of natural products.

[55]  A. Backlund,et al.  Selective Cytotoxicity Evaluation in Anticancer Drug Screening of Fractionated Plant Extracts , 2002, Journal of biomolecular screening.

[56]  Z. Kele,et al.  Isolation of a new member of the ecdysteroid glycoside family: 2-deoxy-20-hydroxyecdysone 22-O-beta-D-glucopyranoside. , 2002, Journal of chromatographic science.

[57]  G. Kusano,et al.  Studies on the Constituents of Cimicifuga Species. XXVII. Malonyl Cyclolanostanol Glycosides from the Underground Parts of Cimicifuga simplex WORMSK. , 1999 .

[58]  M. Buděšínský,et al.  New ergostane type ecdysteroids from fungi. Ecdysteroid constituents of mushroom Paxillus atrotomentosus , 1998 .

[59]  U. Baltaev.  Rapisterone D, a phytoecdysteroid from Rhaponticum carthamoides , 1995 .

[60]  M. Schubert-Zsilavecz,et al.  The structure of hellebrin , 1995 .

[61]  A. Freyer,et al.  Morphinandienone alkaloids from Roemeria refracta. , 1990 .

[62]  F. Tomé,et al.  Phytochemical evaluation of Helleborus Species Growing in Northern Italy , 1990 .

[63]  J. Breinholt,et al.  Two iridoid glycosides from Chaenorrhinum minus , 1990 .

[64]  M. Wichtl,et al.  Bufadienolide aus Samen von Helleborus odorus , 1986 .

[65]  T. Smith.  Pharmacokinetics, bioavailability and serum levels of cardiac glycosides. , 1985, Journal of the American College of Cardiology.

[66]  H. Jha,et al.  A furostanol glycoside from Helleborus macranthus , 1984 .

[67]  R. Hocquemiller,et al.  [Alkaloids from Annonaceae XLVII*: Alkaloides of Guatteria ouregou**]. , 1983, Planta medica.

[68]  K. Kudo,et al.  Lignan-Glycosides from the Bark of Ligstrum japonicum , 1980 .

[69]  H. G. Fletcher,et al.  Crystalline cellobiono-1, 5-lactone: its preparation and growth-inhibitory activity in the Avena coleoptile section test. , 1974, Carbohydrate research.

[70]  S. Murase,et al.  [The structure of cis-and trans-glaupadiol (studies on the constituents of the rhizomes of Glaucidium palmatum Sieb. et Zucc.)]. , 1973, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[71]  K. Stöckel,et al.  Hirundigenin and anhydrohirundigenin, two natural 15-oxasteroids of plant origin. Chemical and x-ray investigation. , 1968 .

[72]  M. Shamma,et al.  Thalictrum alkaloids—VII , 1967 .

[73]  J. Schmutz.  Die Konstitution des Hellebrigenins. Glykoside und Aglykone, 48. Mitteilung , 1949 .

[74]  T. Miyase,et al.  Twelve New Cyclolanostanol Glycosides from the Underground Parts of Cimicifuga simplex WORMSK , 2022 .