Suppression of Autonomic‐Mediated Triggered Firing in Pulmonary Vein Preparations, 24 Hours Postcoronary Artery Ligation in Dogs

Introduction: Rapid arrhythmia originating within pulmonary veins (PVs) precipitates atrial fibrillation (AF) in man. To determine a possible basis for an increased incidence of AF observed peri‐myocardial infarction in man, we compared AF induction in vivo and triggered arrhythmia formation within isolated PVs in vitro in normal dogs and dogs studied 24 hours postcoronary artery ligation.

[1]  R Lazzara,et al.  Focal Atrial Fibrillation: Experimental Evidence for a Pathophysiologic Role of the Autonomic Nervous System , 2001, Journal of cardiovascular electrophysiology.

[2]  R. M. Conant,et al.  Autonomic Disturbance at Onset of Acute Myocardial Infarction , 1972, British medical journal.

[3]  K. Kaufman,et al.  Proteasome degradation of GRK 2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction , 2005 .

[4]  Shih‐Ann Chen,et al.  Electrophysiology of Pulmonary Veins , 2006, Journal of cardiovascular electrophysiology.

[5]  Federico Lombardi,et al.  Autonomic nervous system and paroxysmal atrial fibrillation: a study based on the analysis of RR interval changes before, during and after paroxysmal atrial fibrillation. , 2004, European heart journal.

[6]  C. Tai,et al.  Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation. , 1999, Circulation.

[7]  D. W. Cheung.  Electrical activity of the pulmonary vein and its interaction with the right atrium in the guinea‐pig. , 1981, The Journal of physiology.

[8]  Mitsuru Yamamoto,et al.  Pacing-Induced Spontaneous Activity in Myocardial Sleeves of Pulmonary Veins After Treatment With Ryanodine , 2003, Circulation.

[9]  C. Tai,et al.  Role of atrial electrophysiology and autonomic nervous system in patients with supraventricular tachycardia and paroxysmal atrial fibrillation. , 1998, Journal of the American College of Cardiology.

[10]  R. Lazzara,et al.  Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation. , 2005, Heart rhythm.

[11]  S. A. Chen,et al.  Arrhythmogenic activity of cardiac muscle in pulmonary veins of the dog: implication for the genesis of atrial fibrillation. , 2000, Cardiovascular research.

[12]  Craig T. January,et al.  Early Afterdepolarizations: Mechanism of Induction and Block A Role for L‐Type Ca2+ Current , 1989, Circulation research.

[13]  R. Lazzara,et al.  Role of Na+:Ca2+ Exchange Current in Cs+‐Induced Early Afterdepolarizations in Purkinje Fibers , 1994, Journal of cardiovascular electrophysiology.

[14]  Hong Liu,et al.  Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins. , 2006, Journal of the American College of Cardiology.

[15]  R. Lefkowitz,et al.  Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. , 1998, Circulation.

[16]  J Clémenty,et al.  Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. , 1998, The New England journal of medicine.

[17]  P Coumel,et al.  Autonomic Influences in Atrial Tachyarrhythmias , 1996, Journal of cardiovascular electrophysiology.

[18]  David Amar,et al.  Competing autonomic mechanisms precede the onset of postoperative atrial fibrillation. , 2003, Journal of the American College of Cardiology.

[19]  M. Lohse,et al.  Activation of β-Adrenergic Receptor Kinase During Myocardial Ischemia , 1996 .

[20]  W. Koch,et al.  Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase* , 1997, The Journal of Biological Chemistry.

[21]  Sander Verheule,et al.  Arrhythmogenic Substrate of the Pulmonary Veins Assessed by High-Resolution Optical Mapping , 2003, Circulation.

[22]  A. S. Harris.  Delayed Development of Ventricular Ectopic Rhythms following Experimental Coronary Occlusion , 1950, Circulation.