Pulse therapy. Therapeutic efficacy in the treatment of pyoderma gangrenosum.

• Three patients with pyoderma gangrenosum were treated with suprapharmacologic doses of methylprednisolone sodium succinate using a five-day pulse therapy regimen. This therapy produced a dramatic remission with minimal side effects. The effects of pulse therapy are reviewed, and its role in severe steroid-responsive dermatoses is discussed. ( Arch Dermatol 1982;118:76-84)

[1]  L. Espinoza,et al.  Sudden death after methylprednisolone pulse therapy. , 1981, Annals of internal medicine.

[2]  B. Haynes,et al.  Phenotypic characterization of cutaneous T-cell lymphoma. Use of monoclonal antibodies to compare with other malignant T cells. , 1981, The New England journal of medicine.

[3]  M. D. Freedman,et al.  Anaphylaxis after intravenous methylprednisolone administration. , 1981, JAMA.

[4]  H. Paulus,et al.  Pulse methylprednisolone in rheumatoid arthritis: a double-blind cross-over trial. , 1981, Annals of internal medicine.

[5]  Nelson Am,et al.  Series on pharmacology in practice. 9. Glucocorticoids in rheumatic disease. , 1980 .

[6]  J. Miller,et al.  Prolonged use of large intravenous steroid pulses in the rheumatic diseases of children. , 1980, Pediatrics.

[7]  J. Meyer,et al.  Pulse methylprednisolone therapy in idiopathic, rapidly progressive glomerulonephritis. , 1980, Annals of internal medicine.

[8]  G. Nuki,et al.  Pyoderma Gangrenosum: CLINICAL AND LABORATORY FINDINGS IN 15 PATIENTS WITH SPECIAL REFERENCE TO POLYARTHRITIS , 1980, Medicine.

[9]  P. Holt.  The current status of pyoderma gangrenosum , 1979, Clinical and experimental dermatology.

[10]  W. F. Lever.  Pemphigus and pemphigoid: A review of the advances made since 1964 , 1979 .

[11]  W. Etheridge,et al.  High-dose corticosteroids: their use in treating idiopathic rapidly progressive glomerulonephritis. , 1979, Archives of internal medicine.

[12]  W. Couser,et al.  Intravenous pulse methylprednisolone therapy of acute crescentic rapidly progressive glomerulonephritis. , 1979, The American journal of medicine.

[13]  I. Sneddon,et al.  Subcorneal pustular dermatosis , 1979, The British journal of dermatology.

[14]  I. Slotki,et al.  The treatment of lupus nephritis by methyl prednisolone pulse therapy. , 1978, Postgraduate medical journal.

[15]  A. Saxon,et al.  Glucocorticoids administered in vivo inhibit human suppressor T lymphocyte function and diminish B lymphocyte responsiveness in in vitro immunoglobulin synthesis. , 1978, The Journal of clinical investigation.

[16]  A. Daar,et al.  ORAL VERSUS INTRAVENOUS HIGH-DOSE STEROID TREATMENT OF RENAL ALLOGRAFT REJECTION The Big Shot or Not? , 1978, The Lancet.

[17]  P. Nilsson,et al.  Pyoderma gangrenosum associated with regional enteritis. Improvement in defective granulocyte function and healing of skin lesions during administration of clofazimine. , 2009, Acta medica Scandinavica.

[18]  G. Neild,et al.  Methylprednisolone pulse therapy in the treatment of polyarteritis nodosa. , 1977, Postgraduate medical journal.

[19]  T. Nebout,et al.  INTRAVENOUS METHYLPREDNISOLONE PULSES IN DIFFUSE PROLIFERATIVE LUPUS NEPHRITIS , 1977, The Lancet.

[20]  R. Levinsky,et al.  SERUM IMMUNE COMPLEXES AND DISEASE ACTIVITY IN LUPUS NEPHRITIS , 1977, The Lancet.

[21]  R. Shore.  Pyoderma gangrenosum, defective neutrophil chemotaxis, and leukemia. , 1976, Archives of dermatology.

[22]  Whittier Fc,et al.  Sudden death after bolus steroid therapy for acute rejection. , 1976 .

[23]  R. Mcmillan,et al.  The effect of corticosteroids on human IgG synthesis. , 1976, Journal of immunology.

[24]  A. Fauci,et al.  Glucocorticosteroid therapy: mechanisms of action and clinical considerations. , 1976, Annals of internal medicine.

[25]  J. Brocklebank,et al.  "Pulse" methylprednisolone therapy in the treatment of severe glomerulonephritis. , 1976, The Journal of pediatrics.

[26]  W. Couser,et al.  BENEFICIAL EFFECTS OF METHYLPREDNISOLONE "PULSE" THERAPY IN DIFFUSE PROLIFERATIVE LUPUS NEPHRITIS , 1976, The Lancet.

[27]  K. Greer,et al.  Acute febrile neutrophilic dermatosis (Sweet syndrome). , 1975, Archives of dermatology.

[28]  A. Fauci,et al.  Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone. , 1975, The Journal of clinical investigation.

[29]  D. Rosenthal,et al.  Pyoderma Gangrenosum and rheumatoid arthritis. , 1975, Archives of dermatology.

[30]  K. Gunawardena,et al.  The clinical spectrum of Sweet's syndrome (acute febrile neutrophilic dermatosis)—a report of eighteen cases , 1975, The British journal of dermatology.

[31]  A. Fauci.  Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and b lymphocytes to the bone marrow. , 1975, Immunology.

[32]  A. Fauci,et al.  Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity. , 1975, Journal of immunology.

[33]  A. Fauci,et al.  Alternate-day prednisone therapy and human lymphocyte subpopulations. , 1975, The Journal of clinical investigation.

[34]  S. Balcerzak,et al.  Effects of corticosteroids on human monocyte function. , 1974, The Journal of clinical investigation.

[35]  A. Fauci,et al.  Alternate-day prednisone. Leukocyte kinetics and susceptibility to infections. , 1974, The New England journal of medicine.

[36]  R. Persellin,et al.  Effects of steroid hormones on human polymorphonuclear leukocyte lysosomes. , 1974, The Journal of clinical investigation.

[37]  A. Oronsky,et al.  Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation. , 1974, The Journal of laboratory and clinical medicine.

[38]  E. Meltzer,et al.  Anaphylaxis-like reactions to corticosteroid therapy. , 1974, The Journal of allergy and clinical immunology.

[39]  T. Mohanakumar,et al.  Human leukemia cell antigens: serologic characterization with xenoantisera. , 1974, Journal of the National Cancer Institute.

[40]  Woods Je,et al.  Cellular immunity after intravenous administration of methylprednisolone. , 1974 .

[41]  I. Cohen,et al.  STIMULATION OF RAT LYMPHOCYTE PROLIFERATION BY HYDROCORTISONE DURING THE INDUCTION OF CELL-MEDIATED IMMUNITY IN VITRO , 1974, Transplantation.

[42]  P. Clements,et al.  Human lymphocyte subpopulations. Effect of corticosteroids. , 1974, The Journal of clinical investigation.

[43]  D. Cripps,et al.  Subcorneal pustular dermatosis in children. , 1974, Archives of dermatology.

[44]  A. Fauci,et al.  The effect of in vivo hydrocortisone on subpopulations of human lymphocytes. , 1974, The Journal of clinical investigation.

[45]  C. Tay.  Pyoderma Gangrenosum and Leukemia , 1973 .

[46]  R. Rossen,et al.  Effects of corticosteroids on immunity in man. I. Decreased serum IgG concentration caused by 3 or 5 days of high doses of methylprednisolone. , 1973, The Journal of clinical investigation.

[47]  G. Krueger,et al.  Mechanism of cortisol inhibition of adoptive transfer of tuberculin sensitivity. , 1973, The Journal of laboratory and clinical medicine.

[48]  J. Atkinson,et al.  Effects of corticosteroids and splenectomy on the immune clearance and destruction of erythrocytes. , 1973, The Journal of clinical investigation.

[49]  I. Cohen,et al.  The effect of hydrocortisone on lymphocyte-mediated cytolysis. , 1973, Cellular immunology.

[50]  J. Balow,et al.  GLUCOCORTICOID SUPPRESSION OF MACROPHAGE MIGRATION INHIBITORY FACTOR , 1973, The Journal of experimental medicine.

[51]  G. Krueger,et al.  Site of action of cortisol in cellular immunity. , 1973, Journal of immunology.

[52]  W. J. Johnson,et al.  High-dosage intravenously administered methylprednisolone in renal transplantation. A preliminary report. , 1973, JAMA.

[53]  R. van Furth,et al.  THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE PROLIFERATION AND KINETICS OF PROMONOCYTES AND MONOCYTES OF THE BONE MARROW , 1973, The Journal of experimental medicine.

[54]  R. Winkelmann,et al.  Bullous pyoderma gangrenosum and leukemia. , 1972, Archives of dermatology.

[55]  T. Vischer.  Effect of hydrocortisone on the reactivity of thymus and spleen cells of mice to in vitro stimulation. , 1972, Immunology.

[56]  H. Claman.  Corticosteroids and lymphoid cells. , 1972, The New England journal of medicine.

[57]  J. Cohen.  Thymus-derived lymphocytes sequestered in the bone marrow of hydrocortisone-treated mice. , 1972, Journal of immunology.

[58]  Y. Marmary,et al.  The in vitro effect of hydrocortisone on the uptake and intracellular digestion of particulate matter by macrophages in culture. , 1972, Laboratory investigation; a journal of technical methods and pathology.

[59]  L. Goldsmith,et al.  Pyoderma gangrenosum, altered delayed hypersensitivity and polyarthritis. , 1972, Archives of dermatology.

[60]  A. Mowat,et al.  Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis. , 1971, The Journal of clinical investigation.

[61]  O. Werdelin,et al.  THE NATURE AND THE SPECIFICITY OF MONONUCLEAR CELLS IN EXPERIMENTAL AUTOIMMUNE INFLAMMATIONS AND THE MECHANISMS LEADING TO THEIR ACCUMULATION , 1971, The Journal of experimental medicine.

[62]  J. Cream.  PYODERMA GANGRENOSUM WITH A MONOCLONAL IgM RED CELL AGGLOMERATING FACTOR , 1971, The British journal of dermatology.

[63]  P. Bodel,et al.  Studies on steroid fever. II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man. , 1970, The Journal of clinical investigation.

[64]  T. Waldmann,et al.  The effect of hydrocortisone on immunoglobulin metabolism. , 1970, The Journal of clinical investigation.

[65]  E. Hook,et al.  The effect of an NADH oxidase inhibitor (hydrocortisone) on polymorphonuclear leukocyte bactericidal activity. , 1970, The Journal of clinical investigation.

[66]  D. David,et al.  Adrenal glucocorticoids after twenty years. A review of their clinically relevant consequences. , 1970, Journal of chronic diseases.

[67]  R. van Furth,et al.  THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE KINETICS OF MONONUCLEAR PHAGOCYTES , 1970, Journal of Experimental Medicine.

[68]  B. Zegers,et al.  Monoclonal gammopathy (IgG) and chronic ulcerative dermatitis (phagedenic pyoderma). , 2009 .

[69]  K. Hougaard,et al.  AUTORADIOGRAPHIC STUDIES OF EOSINOPHIL KINETICS: EFFECTS OF CORTISOL * , 1969 .

[70]  M. L. Johnson,et al.  Skin lesions in ulcerative colitis. , 1969, Gut.

[71]  F. Wollheim.  Inverse effect on the serum levels of gamma-G- and gamma-M-globulins after prednisone treatment of lupoid hepatitis. , 1967, Clinical and Experimental Immunology.

[72]  C. Craddock,et al.  THE IMMUNE RESPONSE TO FOREIGN RED BLOOD CELLS AND THE PARTICIPATION OF SHORT-LIVED LYMPHOCYTES , 1967, The Journal of experimental medicine.

[73]  G. Stathers,et al.  Pyoderma gangrenosum in association with regional enteritis. , 1967, Archives of dermatology.

[74]  P. Ward.  THE CHEMOSUPPRESSION OF CHEMOTAXIS , 1966, The Journal of experimental medicine.

[75]  I. Sluis.  Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β2A-paraprotein) , 1966 .

[76]  J. Landon,et al.  A RAPID TEST OF ADRENOCORTICAL FUNCTION. , 1965, Lancet.

[77]  Bishopric Ga,et al.  PYODERMA GANGRENOSUM AS THE PRESENTING SIGN OF REGIONAL ILEITIS: OBSERVATIONS REGARDING THE PATHOGENESIS OF THE SKIN LESIONS. , 1964 .

[78]  G. Cartwright,et al.  THE EFFECT OF ADRENAL GLUCOCORTICOSTEROIDS UPON THE CELLULAR COMPOSITION OF INFLAMMATORY EXUDATES. , 1964, The American journal of pathology.

[79]  M. A. Cowan.  ULCERATION OF THE SKIN IN MULTIPLE MYELOMA. , 1961, The British journal of dermatology.

[80]  J. Hirsch,et al.  Adrenal steroids and infection: the effect of cortisone administration on polymorphonuclear leukocytic functions and on serum opsonins and bactericidins. , 1961, The Journal of clinical investigation.

[81]  H. Perry,et al.  Pyoderma Gangrenosum: A Clinical Study of Nineteen Cases , 1957 .