ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.
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C. Jung | M. Kundu | Do-Hyung Kim | Seung-Hyun Ro | N. Otto | Young-Mi Kim | Chang-Bong Jun | Jing Cao
[1] T. P. Neufeld,et al. An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. , 2009, Molecular biology of the cell.
[2] J. Guan,et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. , 2009, Molecular biology of the cell.
[3] S. Tooze,et al. Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism , 2008, Molecular and Cellular Biology.
[4] C. Thompson,et al. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. , 2008, Blood.
[5] M. Murakami,et al. Autophagy Is Essential for Preimplantation Development of Mouse Embryos , 2008, Science.
[6] T. P. Neufeld,et al. Eating on the fly: Function and regulation of autophagy during cell growth, survival and death in Drosophila , 2008, Autophagy.
[7] T. Vellai,et al. Regulation of cell growth by autophagy , 2008, Autophagy.
[8] J. Guan,et al. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells , 2008, The Journal of cell biology.
[9] Daniel J. Klionsky,et al. Autophagy fights disease through cellular self-digestion , 2008, Nature.
[10] Guido Kroemer,et al. Autophagy in the Pathogenesis of Disease , 2008, Cell.
[11] S. Sugimoto. A Novel Vacuolar Myopathy with Dilated Cardiomyopathy , 2007, Autophagy.
[12] S. Tooze,et al. siRNA Screening of the Kinome Identifies ULK1 as a Multidomain Modulator of Autophagy* , 2007, Journal of Biological Chemistry.
[13] N. Mizushima,et al. How to Interpret LC3 Immunoblotting , 2007, Autophagy.
[14] YongSung Kim,et al. ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase , 2007, EMBO reports.
[15] Marten Veenhuis,et al. ATG Genes Involved in Non-Selective Autophagy are Conserved from Yeast to Man, but the Selective Cvt and Pexophagy Pathways also Require Organism-Specific Genes , 2007, Autophagy.
[16] Timothy J. Griffin,et al. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 , 2007, Nature Cell Biology.
[17] Y. Ohsumi,et al. Hierarchy of Atg proteins in pre‐autophagosomal structure organization , 2007, Genes to cells : devoted to molecular & cellular mechanisms.
[18] T. P. Neufeld,et al. Direct Induction of Autophagy by Atg1 Inhibits Cell Growth and Induces Apoptotic Cell Death , 2007, Current Biology.
[19] R. Kessin,et al. Function of the Dictyostelium discoideum Atg1 Kinase during Autophagy and Development , 2006, Eukaryotic Cell.
[20] D. Klionsky,et al. Atg17 regulates the magnitude of the autophagic response. , 2005, Molecular biology of the cell.
[21] Hiroshi Sagara,et al. Escape of Intracellular Shigella from Autophagy , 2005, Science.
[22] M. W. Clark,et al. Regulation of cell growth , 2005, Experientia.
[23] V. Deretic,et al. Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages , 2004, Cell.
[24] T. P. Neufeld,et al. Role and regulation of starvation-induced autophagy in the Drosophila fat body. , 2004, Developmental cell.
[25] A. Yamamoto,et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation , 2004, Journal of Cell Science.
[26] Francesco Scaravilli,et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease , 2004, Nature Genetics.
[27] O. Roger Anderson,et al. Dictyostelium Macroautophagy Mutants Vary in the Severity of Their Developmental Defects* , 2004, Journal of Biological Chemistry.
[28] M. Hatten,et al. Role of Unc51.1 and its binding partners in CNS axon outgrowth. , 2004, Genes & development.
[29] Govind Bhagat,et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. , 2003, The Journal of clinical investigation.
[30] Arnold J. Levine,et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[31] D. Hall,et al. Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans , 2003, Science.
[32] J. Blenis,et al. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb , 2003, Current Biology.
[33] E. Hafen,et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila , 2003, Nature Cell Biology.
[34] B. Edgar,et al. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins , 2003, Nature Cell Biology.
[35] B. Edgar,et al. Rheb promotes cell growth as a component of the insulin/TOR signalling network , 2003, Nature Cell Biology.
[36] D. Sabatini,et al. mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.
[37] Y. Masuho,et al. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. , 2000, Brain research. Molecular brain research.
[38] Tobias Schmelzle,et al. TOR, a Central Controller of Cell Growth , 2000, Cell.
[39] Kazuya Nagano,et al. Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex , 2000, The Journal of cell biology.
[40] H. Hibshoosh,et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1 , 1999, Nature.
[41] D. Klionsky,et al. Vacuolar import of proteins and organelles from the cytoplasm. , 1999, Annual review of cell and developmental biology.
[42] Takeshi Noda,et al. Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast* , 1998, The Journal of Biological Chemistry.
[43] A. Matsuura,et al. Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. , 1997, Gene.
[44] A. Matsuura,et al. Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. , 1997, Gene.
[45] T. S. P. S.,et al. GROWTH , 1924, Nature.