SPONTANEOUS MEDIASTINAL AND SUBCUTANEOUS EMPHYSEMA COMPLICATING BRONCHIAL ASTHMA

ping tends to regress in time whereas heterotopic ossification progresses rapidly to a certain stage, and thereafter remains constant and recurs if excised surgically (Miller and O'Neill, 1949). Dejerine (1918) believed that this condition was due to metaplasia of connective tissue due to trophic effects of the central nervous system lesion. She held that the <edema which precedes ossification in some way modifies the behaviour of the connective tissue cells. Geldmacher (1925) made similar suggestions. Metaplasia, the transformation of adult tissue of one kind into a different kind in abnormal circumstances, is well known. Willis (1962) has reported great transformations in cellular behaviour in all manner of abnormal environments. In such circumstances, cells reveal their dormant plasticity.

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