Surgery for primary basal cell carcinoma including the eyelid margins with intraoperative frozen section control: comparative interventional study with a minimum clinical follow up of 5 years

Aim: To assess recurrence of primary basal cell carcinoma (PBCC) including the eyelid margins after resection with or without intraoperative frozen section control (IFS). Methods: Comparative non-randomised interventional study involving review of records of consecutive patients with histological diagnosis of PBCC including the eyelid margins, treated surgically at the University of Erlangen-Nürnberg between 1989 and 1998. Patients with a minimum clinical follow up of 5 years treated with (group I) or without (group II) IFS were compared. Postoperatively, permanent paraffin sections were available in all patients. Results: 165 patients were available for study. There were 145 patients with a minimum of 5 years follow up. Of these, no tumour recurrences were observed in group I (n = 114) compared with three (9.7%) in group II (n = 31) (p = 0.002). Conclusions: Surgery for PBCC including the eyelid margins with IFS and immediate plastic reconstruction, as performed in the present study, is associated with better long term cure compared with surgery with clinical control.

[1]  K. Whitehead,et al.  Management of Periocular Basal Cell Carcinoma With Modified En Face Frozen Section Controlled Excision , 2002, Ophthalmic plastic and reconstructive surgery.

[2]  L. Kelley,et al.  Predictors of extensive subclinical spread in nonmelanoma skin cancer treated with Mohs micrographic surgery. , 2002, Archives of dermatology.

[3]  G. Bartley,et al.  Treatment options and future prospects for the management of eyelid malignancies: an evidence-based update. , 2001, Ophthalmology.

[4]  S. Pieh,et al.  Long term results after surgical basal cell carcinoma excision in the eyelid region , 1999, The British journal of ophthalmology.

[5]  A. Jünemann,et al.  Gefriermikroskopisch kontrollierte Exzision von Lid-Basaliomen und plastische Rekonstruktion in einer Sitzung : Indikationen und Methoden bei 106 Patienten , 1998 .

[6]  W. Threlfall,et al.  Basal Cell Carcinoma of the Periocular Region , 1998, Journal of cutaneous medicine and surgery.

[7]  A. Jünemann,et al.  [Surgical management of periocular basal cell carcinoma using frozen section control and immediate plastic reconstruction--indications and methods in 106 patients]. , 1998, Klinische Monatsblatter fur Augenheilkunde.

[8]  Steinkogler Fj,et al.  The necessity of long-term follow up after surgery for basal cell carcinomas of the eyelid. , 1993 .

[9]  C. Margo,et al.  Basal cell carcinoma of the eyelid and periocular skin. , 1993, Survey of ophthalmology.

[10]  C. Scholda,et al.  The necessity of long-term follow up after surgery for basal cell carcinomas of the eyelid. , 1993, Ophthalmic surgery.

[11]  C. Shields.  Basal Cell Carcinoma of the Eyelids , 1993, International ophthalmology clinics.

[12]  H. Glatt,et al.  Conventional frozen sections in periocular basal-cell carcinoma: a review of 236 cases. , 1992, Ophthalmic surgery.

[13]  N. Walker,et al.  Micrographic (MOHS') surgery in the management of periocular basal cell epitheliomas , 1990, Eye.

[14]  H. J. Frank.  Frozen section control of excision of eyelid basal cell carcinomas: 8 1/2 years' experience. , 1989, The British journal of ophthalmology.

[15]  G. Monheit,et al.  Twelve years' experience with the Mohs-Tromovitch technique of skin cancer removal. , 1989, International ophthalmology clinics.

[16]  F. Mohs.  Micrographic surgery for the microscopically controlled excision of eyelid cancers. , 1986, Archives of ophthalmology.

[17]  D. Rigel,et al.  Mohs surgery for periocular basal cell carcinomas. , 1985, The Journal of dermatologic surgery and oncology.

[18]  G. Georgiade,et al.  A Rationale for the Treatment of Difficult Basal Cell and Squamous Cell Carcinomas of the Skin , 1985, Annals of plastic surgery.

[19]  T. Akiyama,et al.  :A long term follow-up study , 1982 .

[20]  A. Putterman,et al.  Frozen section control in the surgery of basal cell carcinoma of the eyelid. , 1979, American journal of ophthalmology.

[21]  R. Butner,et al.  Basal cell carcinoma of the eyelids. A long-term follow-up study. , 1969, Archives of ophthalmology.