easyLINKAGE: a PERL script for easy and automated two-/multi-point linkage analyses

UNLABELLED We have generated the program easyLINKAGE that combines automated setup and performance of linkage analyses and simulation under an easy to handle graphical user interface for Microsoft Windows 2000/XP and standard UNIX systems. The program package supports two-point linkage analyses (FastLink v4.1 and SPLink v1.09), multi-point linkage analyses [GENEHUNTER v2.1, GENEHUNTER-PLUS with the emendation by Kong and Cox v1.2 (allele sharing modelling)] and the simulation package SLINK v2.65, and provides genome-wide as well as chromosomal postscript plots of LOD scores, NPL scores, P-values and other parameters. AVAILABILITY http://www.uni-wuerzburg.de/nephrologie/molecular_genetics/molecular_genetics.htm SUPPLEMENTARY INFORMATION Supplementary information is available on the website.

[1]  P. Holmans,et al.  Asymptotic properties of affected-sib-pair linkage analysis. , 1993, American journal of human genetics.

[2]  L Kruglyak,et al.  Parametric and nonparametric linkage analysis: a unified multipoint approach. , 1996, American journal of human genetics.

[3]  A A Schäffer,et al.  Faster sequential genetic linkage computations. , 1993, American journal of human genetics.

[4]  D. Clayton,et al.  Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers. , 1995, American journal of human genetics.

[5]  J. Ott Computer-simulation methods in human linkage analysis. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[6]  N J Cox,et al.  Allele-sharing models: LOD scores and accurate linkage tests. , 1997, American journal of human genetics.