Adenoidal Disease and Chronic Rhinosinusitis in Children—Is There a Link?

Adenoid hypertrophy (AH) is an extremely common condition in the pediatric and adolescent populations that can lead to various medical conditions, including acute rhinosusitis, with a percentage of these progressing to chronic rhinosinusitis (CRS). The relationship between AH and pediatric CRS has been extensively studied over the past few years and clinical consensus on the treatment has now been reached, allowing this treatment to become the preferred clinical practice. The purpose of this study is to review existing literature and data on the relationship between AH and CRS and the options for treatment. A systematic literature review was performed using a search line for “(Adenoiditis or Adenoid Hypertrophy) and Sinusitis and (Pediatric or Children)”. At the end of the evaluation, 36 complete texts were analyzed, 17 of which were considered eligible for the final study, dating from 1997 to 2018. The total population of children assessed in the various studies was of 2371. The studies were categorized as surgical-observational, microbiological, genetic-immunological, and radiological. The analysis of the studies confirms the relationship between AH and CRS and supports the existing consensus on medical and surgical therapy. Furthermore, these studies underline the necessity to adapt medical and surgical treatment considering age, comorbidities including asthma and, if present, the Computed Tomography (CT) score.

[1]  Jivianne T. Lee,et al.  Clinical Guidelines on Chronic Rhinosinusitis in Children , 2019, Current Allergy and Asthma Reports.

[2]  Frank W Virgin,et al.  The Role of the Adenoids in Pediatric Chronic Rhinosinusitis , 2019, Medical sciences.

[3]  M. Gerber,et al.  Adenoidectomy With Balloon Catheter Sinuplasty: A Randomized Trial for Pediatric Rhinosinusitis , 2018, The Laryngoscope.

[4]  H. Ramadan,et al.  Sinus and Upper Airway Surgery in Children , 2018, Current Allergy and Asthma Reports.

[5]  C. Flores‐Mir,et al.  Prevalence of adenoid hypertrophy: A systematic review and meta-analysis. , 2017, Sleep medicine reviews.

[6]  A. Messner,et al.  Pediatric Chronic Rhinosinusitis Management in Rhinologists and Pediatric Otolaryngologists , 2017, The Annals of otology, rhinology, and laryngology.

[7]  D. Ortiz-Princz,et al.  Adenoid hypertrophy and chronic rhinosinusitis: Helicobacter pylori on antral lavages, adenoid tissue and salival inmunoglobuline A on paediatric patients. , 2016, International journal of pediatric otorhinolaryngology.

[8]  Haiqin Liu,et al.  Health-related quality of life among children with adenoid hypertrophy in Xi'an, China. , 2015, International journal of pediatric otorhinolaryngology.

[9]  Ana Kaftandzhieva,et al.  Adenoid Vegetations – Reservoir of Bacteria for Chronic Otitis Media with Effusion and Chronic Rhinosinusitis , 2015, Prilozi.

[10]  Hong Wang,et al.  Expression of Innate Immunity Genes in Epithelial Cells of Hypertrophic Adenoids with and without Pediatric Chronic Rhinosinusitis: A Preliminary Report , 2015, Chinese medical journal.

[11]  D. Hamilos Pediatric Chronic Rhinosinusitis , 2015, American journal of rhinology & allergy.

[12]  Xie-Qi Shi,et al.  Comparative analysis of upper airway volume with lateral cephalograms and cone-beam computed tomography. , 2015, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[13]  R. Rosenfeld,et al.  Clinical Consensus Statement , 2014, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[14]  F. Silviu-Dan Pediatric chronic rhinosinusitis. , 2014, Pediatric annals.

[15]  M. Farhadi,et al.  Chlamydophila pneumoniae Infection Assessment in Children With Adenoid Hypertrophy Concomitant With Rhino Sinusitis , 2014, Jundishapur journal of microbiology.

[16]  D. Caimmi,et al.  Adenoids in children: Advances in immunology, diagnosis, and surgery , 2014, Clinical anatomy.

[17]  H. Ramadan,et al.  Can Computed Tomography Score Predict Outcome of Adenoidectomy for Chronic Rhinosinusitis in Children , 2014, American journal of rhinology & allergy.

[18]  N. Bhattacharyya,et al.  Obesity and the risk of chronic rhinosinusitis, allergic rhinitis, and acute otitis media in school‐age children , 2013, The Laryngoscope.

[19]  Nader Shaikh,et al.  Clinical Practice Guideline for the Diagnosis and Management of Acute Bacterial Sinusitis in Children Aged 1 to 18 Years , 2013, Pediatrics.

[20]  Swapna K. Chandran,et al.  Pediatric Rhinosinusitis: Definitions, Diagnosis and Management—An Overview , 2013, American journal of rhinology & allergy.

[21]  Swapna K. Chandran,et al.  Chapter 5: Pediatric rhinosinusitis: Definitions, diagnosis and management-An overview. , 2013, American journal of rhinology & allergy.

[22]  M. Mocellin,et al.  Pan American Guideline on Tonsillitis and Adenoid Hypertrophy , 2012 .

[23]  M. Tsai,et al.  Association of adenoid hyperplasia and bacterial biofilm formation in children with adenoiditis in Taiwan , 2012, European Archives of Oto-Rhino-Laryngology.

[24]  D. Park,et al.  Immunoglobulins and transcription factors in adenoids of children with otitis media with effusion and chronic rhinosinusitis. , 2009, International journal of pediatric otorhinolaryngology.

[25]  G. Choi,et al.  Immunological investigation in the adenoid tissues from children with chronic rhinosinusitis , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[26]  Seung Hwan Lee,et al.  The role of adenoids in pediatric rhinosinusitis. , 2008, International journal of pediatric otorhinolaryngology.

[27]  B. Yawn,et al.  EPOS Primary Care Guidelines: European Position Paper on the Primary Care Diagnosis and Management of Rhinosinusitis and Nasal Polyps 2007 - a summary. , 2008, Primary care respiratory journal : journal of the General Practice Airways Group.

[28]  H. Ramadan,et al.  Outcome of Adenoidectomy Versus Adenoidectomy With Maxillary Sinus Wash for Chronic Rhinosinusitis in Children , 2008, The Laryngoscope.

[29]  H. Ramadan,et al.  Failures of Adenoidectomy for Chronic Rhinosinusitis in Children: For Whom and When Do They Fail? , 2007, The Laryngoscope.

[30]  Catherine Klersy,et al.  The 10-day mark is a good way to diagnose not only acute rhinosinusitis but also adenoiditis, as confirmed by endoscopy. , 2007, International journal of pediatric otorhinolaryngology.

[31]  R. Berk,et al.  Biofilm surface area in the pediatric nasopharynx: Chronic rhinosinusitis vs obstructive sleep apnea. , 2007, Archives of otolaryngology--head & neck surgery.

[32]  N. Bhattacharyya,et al.  The diagnostic accuracy of computed tomography in pediatric chronic rhinosinusitis. , 2004, Archives of otolaryngology--head & neck surgery.

[33]  K. Ungkanont,et al.  Effect of adenoidectomy in children with complex problems of rhinosinusitis and associated diseases. , 2004, International journal of pediatric otorhinolaryngology.

[34]  J. Bernstein,et al.  Molecular Typing of Paired Bacterial Isolates From the Adenoid and Lateral Wall of the Nose in Children Undergoing Adenoidectomy: Implications in Acute Rhinosinusitis , 2001, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[35]  G. Canonica,et al.  Nasal endoscopy in asthmatic children: assessment of rhinosinusitis and adenoiditis incidence, correlations with cytology and microbiology , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[36]  S. J. Vandenberg,et al.  Efficacy of adenoidectomy in relieving symptoms of chronic sinusitis in children. , 1997, Archives of otolaryngology--head & neck surgery.

[37]  L. Kaufman,et al.  Assessment of adenoid size in children by fibreoptic examination. , 1997, Clinical otolaryngology and allied sciences.

[38]  J. Ballantyne,et al.  An Investigation Into the Relationship Between Adenoids and Sinusitis in Children , 1952, The Journal of Laryngology & Otology.