Supramolecular nanofiber of indomethacin derivative confers highly cyclooxygenase-2 (COX-2) selectivity and boosts anti-inflammatory efficacy.

[1]  Xingyi Li,et al.  A Biomimetic Peptide-drug Supramolecular Hydrogel as Eyedrops Enables Controlled Release of Ophthalmic Drugs. , 2023, Acta biomaterialia.

[2]  V. Adam,et al.  Enhanced macrophage polarization induced by COX-2 inhibitor-loaded Pd octahedral nanozymes for treatment of atherosclerosis , 2022, Chinese Chemical Letters.

[3]  Yuqin Wang,et al.  Enzyme-instructed self-assembly of peptide-drug conjugates in tear fluids for ocular drug delivery. , 2022, Journal of controlled release : official journal of the Controlled Release Society.

[4]  Z. Qian,et al.  Multifunctional Supramolecular Filament Hydrogel Boosts Anti‐Inflammatory Efficacy In Vitro and In Vivo , 2022, Advanced Functional Materials.

[5]  Xingyi Li,et al.  Cationic Self-Assembled Peptide-Based Molecular Hydrogels for Extended Ocular Drug Delivery , 2021, Acta biomaterialia.

[6]  Yuqin Wang,et al.  Bioinspired self-assembly supramolecular hydrogel for ocular drug delivery , 2021 .

[7]  Serkan Levent,et al.  Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety. , 2020, European journal of medicinal chemistry.

[8]  K. A. Szychowski,et al.  Paracetamol – An old drug with new mechanisms of action , 2020, Clinical and experimental pharmacology & physiology.

[9]  U. Bandyopadhyay,et al.  Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective , 2020, Biochemical Pharmacology.

[10]  L. Marnett,et al.  Structural and Chemical Biology of the Interaction of Cyclooxygenase with Substrates and Non-Steroidal Anti-Inflammatory Drugs , 2020, Chemical reviews.

[11]  P. McGettigan,et al.  Cardiovascular effects and safety of (non-aspirin) NSAIDs , 2020, Nature Reviews Cardiology.

[12]  Bin Li,et al.  Efficiency of Traditional Chinese medicine targeting the Nrf2/HO-1 signaling pathway. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[13]  P. Mozetic,et al.  Ester coupling of ibuprofen in hydrogel matrix: a facile one-step strategy for controlled anti-inflammatory drug release. , 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[14]  Amira M. Ahmed,et al.  COX-1/COX-2 inhibition assays and histopathological study of the new designed anti-inflammatory agent with a pyrazolopyrimidine core. , 2019, Bioorganic chemistry.

[15]  M. J. Uddin,et al.  Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site , 2019, The Journal of Biological Chemistry.

[16]  Yuxi Wang,et al.  Polysaccharide from alfalfa activates RAW 264.7 macrophages through MAPK and NF-κB signaling pathways. , 2019, International journal of biological macromolecules.

[17]  G. Nagaraju,et al.  Cyclooxygenase‐2 in gastrointestinal malignancies , 2019, Cancer.

[18]  B. Ruffell,et al.  Inflammation, ROS, and Mutagenesis. , 2017, Cancer cell.

[19]  Hamed I. Ali,et al.  Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities. , 2017, European journal of medicinal chemistry.

[20]  D. Upadhya,et al.  Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness , 2017, Front. Mol. Neurosci..

[21]  Bing Xu,et al.  Bioinspired assembly of small molecules in cell milieu. , 2017, Chemical Society reviews.

[22]  A. Bhardwaj,et al.  In situ click chemistry generation of cyclooxygenase-2 inhibitors , 2017, Nature Communications.

[23]  Jie Zhou,et al.  Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases on Live Cells. , 2016, Chem.

[24]  M. Perrone,et al.  COX‐1 Inhibitors: Beyond Structure Toward Therapy , 2016, Medicinal research reviews.

[25]  T. Mak,et al.  TNF and ROS Crosstalk in Inflammation. , 2016, Trends in cell biology.

[26]  S. Yiğitaslan,et al.  The Role of Inflammation and COX-Derived Prostanoids in the Effects of Bradykinin on Isolated Rat Aorta and Urinary Bladder , 2012, Inflammation.

[27]  Peiqing Liu,et al.  Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-κB and MAPK Signaling Pathways , 2011, Inflammation.

[28]  Yong-Cheol Shin,et al.  Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice , 2011, Journal of Biomedical Science.

[29]  K. Ramana,et al.  Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. , 2010, Free radical biology & medicine.

[30]  P. Vanhoutte,et al.  COX‐1 and Vascular Disease , 2009, Clinical pharmacology and therapeutics.

[31]  Amer S Qureshi,et al.  Cardiovascular risks of COX inhibition: current perspectives , 2008 .

[32]  R. Thaimattam,et al.  Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors. , 2006, Bioorganic & medicinal chemistry.

[33]  W. Smith Cyclooxygenases, peroxide tone and the allure of fish oil. , 2005, Current opinion in cell biology.

[34]  M. Reilly,et al.  Patients Exposed to Rofecoxib and Celecoxib Have Different Odds of Nonfatal Myocardial Infarction , 2005, Annals of Internal Medicine.

[35]  R. Botting,et al.  Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition , 2004, Pharmacological Reviews.

[36]  H. Mukhtar,et al.  Cyclooxygenase-2 and prostate carcinogenesis. , 2003, Cancer letters.

[37]  R. Flower The development of COX2 inhibitors , 2003, Nature Reviews Drug Discovery.

[38]  J. Mitchell,et al.  Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum? , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[39]  N. V. Chandrasekharan,et al.  COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[40]  T. Tanabe,et al.  Cyclooxygenase isozymes and their gene structures and expression. , 2002, Prostaglandins & other lipid mediators.

[41]  R. Kurumbail,et al.  Cyclooxygenase enzymes: catalysis and inhibition. , 2001, Current opinion in structural biology.

[42]  S. Hernández-Díaz,et al.  Epidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs. , 2001, The American journal of medicine.

[43]  W. Kiefer,et al.  Cyclooxygenase inhibitors--current status and future prospects. , 2001, European journal of medicinal chemistry.

[44]  L. Marnett,et al.  Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. , 2000, Journal of medicinal chemistry.

[45]  C. Hawkey,et al.  COX-2 Selective Nonsteroidal Anti-Inflammatory Drugs , 2000, Drugs.

[46]  Lawrence J. Marnett,et al.  Structural insights into the stereochemistry of the cyclooxygenase reaction , 2000, Nature.

[47]  P. Colville-Nash,et al.  COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease , 2000, The Lancet.

[48]  L. Marnett,et al.  Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[49]  L. Marnett,et al.  Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. , 1998, Journal of medicinal chemistry.

[50]  J. Gierse,et al.  A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors* , 1996, The Journal of Biological Chemistry.

[51]  B. Stricker,et al.  Nonsteroidal Anti-Inflammatory Drugs and Heart Failure , 2012, Drugs.

[52]  F. Bosetti,et al.  Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications. , 2011, Biochimie.

[53]  R. DuBois,et al.  Cyclooxygenase-2: a therapeutic target. , 2002, Annual review of medicine.

[54]  L. Marnett Cyclooxygenase mechanisms. , 2000, Current opinion in chemical biology.

[55]  R. Kurumbail,et al.  Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents , 1996, Nature.