Tutorial on diffuse light transport.

A tutorial introduction to diffuse light transport is presented. The basic analytic equations of time-resolved, steady-state and modulated light transport are introduced. The perturbation method for handling slight heterogeneities in optical properties is outlined. The treatment of boundary conditions such as an air/tissue surface is described. Finite mesh-based numerical methods are introduced to calculate the diffuse light field in complex tissues with arbitrary boundaries. Applications in tissue spectroscopy and imaging illustrate these theoretical and computational tools.

[1]  K. Oughstun,et al.  Optical properties of inhomogeneous materials , 1980, IEEE Journal of Quantum Electronics.

[2]  H. A. Ferwerda,et al.  Scattering and absorption of turbid materials determined from reflection measurements. 1: theory. , 1983, Applied optics.

[3]  P. Barber.  Absorption and scattering of light by small particles , 1984 .

[4]  John C. Adams,et al.  MUDPACK: Multigrid portable FORTRAN software for the efficient solution of linear elliptic partial d , 1989 .

[5]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[6]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[7]  R. Arridget,et al.  The theoretical basis for the determination of optical pathlengths in tissue: temporal and frequency analysis , 1992 .

[8]  Bruce J. Tromberg,et al.  Tissue characterization and imaging using photon density waves , 1993 .

[9]  L.H. Wang,et al.  Influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues , 1993, Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ.

[10]  M. Schweiger,et al.  A finite element approach for modeling photon transport in tissue. , 1993, Medical physics.

[11]  S. Jacques,et al.  Hybrid model of Monte Carlo simulation and diffusion theory for light reflectance by turbid media. , 1993, Journal of the Optical Society of America. A, Optics, image science, and vision.

[12]  L. O. Svaasand,et al.  Boundary conditions for the diffusion equation in radiative transfer. , 1994, Journal of the Optical Society of America. A, Optics, image science, and vision.

[13]  Sergio Fantini,et al.  Semi-infinite-geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation , 1994 .

[14]  B. Pogue,et al.  Frequency-domain optical absorption spectroscopy of finite tissue volumes using diffusion theory. , 1994, Physics in medicine and biology.

[15]  R. Aronson,et al.  Boundary conditions for diffusion of light. , 1995, Journal of the Optical Society of America. A, Optics, image science, and vision.

[16]  L Wang,et al.  MCML--Monte Carlo modeling of light transport in multi-layered tissues. , 1995, Computer methods and programs in biomedicine.

[17]  Frank K. Tittel,et al.  The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues , 1995, Physics in medicine and biology.

[18]  S L Jacques,et al.  Infrared video imaging of subsurface vessels: a feasibility study for the endoscopic management of gastrointestinal bleeding. , 1995, Gastrointestinal endoscopy.

[19]  K. Paulsen,et al.  Spatially varying optical property reconstruction using a finite element diffusion equation approximation. , 1995, Medical physics.

[20]  K D Paulsen,et al.  Initial assessment of a simple system for frequency domain diffuse optical tomography. , 1995, Physics in medicine and biology.

[21]  B. Hooper.  Optical-thermal response of laser-irradiated tissue , 1996 .

[22]  S L Jacques,et al.  Perturbation theory for diffuse light transport in complex biological tissues. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[23]  M S Patterson,et al.  Imaging of fluorescent yield and lifetime from multiply scattered light reemitted from random media. , 1997, Applied optics.

[24]  E Gratton,et al.  Measurements of scattering and absorption changes in muscle and brain. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[25]  R. Cubeddu,et al.  Optical Tomography , 1998, Technical Digest. 1998 EQEC. European Quantum Electronics Conference (Cat. No.98TH8326).

[26]  S. Arridge.  Optical tomography in medical imaging , 1999 .

[27]  Leon Lapidus,et al.  Numerical Solution of Partial Differential Equations in Science and Engineering: Lapidus/Numerical , 1999 .

[28]  S L Jacques,et al.  Modeling photon transport in transabdominal fetal oximetry. , 2000, Journal of biomedical optics.

[29]  S. Shapshay,et al.  Detection of preinvasive cancer cells , 2000, Nature.

[30]  K D Paulsen,et al.  Calibration of near-infrared frequency-domain tissue spectroscopy for absolute absorption coefficient quantitation in neonatal head-simulating phantoms. , 2000, Journal of biomedical optics.

[31]  B Chance,et al.  Quantification of ischemic muscle deoxygenation by near infrared time-resolved spectroscopy. , 2000, Journal of biomedical optics.

[32]  Michael S. Feld,et al.  Imaging human epithelial properties with polarized light-scattering spectroscopy , 2001, Nature Medicine.

[33]  K D Paulsen,et al.  Three-dimensional simulation of near-infrared diffusion in tissue: boundary condition and geometry analysis for finite-element image reconstruction. , 2001, Applied optics.

[34]  Vasilis Ntziachristos,et al.  In vivo tomographic imaging of near-infrared fluorescent probes. , 2002, Molecular imaging.

[35]  R. Weissleder,et al.  Fluorescence molecular tomography resolves protease activity in vivo , 2002, Nature Medicine.

[36]  Changhuei Yang,et al.  In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry. , 2003, Cancer research.

[37]  J. Ripoll,et al.  Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. Lynch.  Numerical Partial Differential Equations for Environmental Scientists and Engineers: A First Practical Course , 2004 .

[39]  Anders M. Dale,et al.  Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy , 2004, NeuroImage.

[40]  Vasilis Ntziachristos,et al.  Fluorescent protein tomography scanner for small animal imaging , 2005, IEEE Transactions on Medical Imaging.

[41]  E. Miller,et al.  Optimal linear inverse solution with multiple priors in diffuse optical tomography. , 2005, Applied optics.

[42]  Brian W Pogue,et al.  Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo. , 2005, Journal of biomedical optics.

[43]  Vasilis Ntziachristos,et al.  Planar fluorescence imaging using normalized data. , 2005, Journal of biomedical optics.

[44]  J. Laible,et al.  Fluorescence photon migration by the boundary element method , 2005 .

[45]  B. Tromberg,et al.  Imaging in breast cancer: Diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy , 2005, Breast Cancer Research.

[46]  B. Pogue,et al.  Spectrally resolved bioluminescence optical tomography. , 2006, Optics letters.

[47]  Jennifer J. Gibson,et al.  In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction. , 2006, Academic radiology.

[48]  Stephen G Bown,et al.  Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique. , 2006, Gastrointestinal Endoscopy.

[49]  J. Mansfield,et al.  Multispectral imaging in biology and medicine: Slices of life , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[50]  David Isaacson,et al.  Electrode boundary conditions and experimental validation for BEM-based EIT forward and inverse solutions , 2006, IEEE Transactions on Medical Imaging.

[51]  J. Ripoll,et al.  Diffuse photon propagation in multilayered geometries , 2006, Physics in medicine and biology.

[52]  Hamid Dehghani,et al.  Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography. , 2006, Journal of biomedical optics.

[53]  B. Pogue,et al.  Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[54]  B. Pogue,et al.  Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size. , 2007, Optics letters.

[55]  B. Pogue,et al.  A boundary element approach for image-guided near-infrared absorption and scatter estimation. , 2007, Medical physics.