Minimalistic graphical presentation approach for total syntheses

[1]  J. T. Njardarson,et al.  Phenols in Pharmaceuticals: Analysis of a Recurring Motif. , 2022, Journal of medicinal chemistry.

[2]  R. Shenvi,et al.  Natural Product Synthesis through the Lens of Informatics. , 2021, Accounts of chemical research.

[3]  J. L. Wood,et al.  Total Synthesis of ent-Plagiochianin B , 2021, Organic letters.

[4]  Thomas P. Stratton,et al.  Ideality in Context: Motivations for Total Synthesis. , 2021, Accounts of chemical research.

[5]  J. T. Njardarson,et al.  A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine. , 2020, Journal of medicinal chemistry.

[6]  K. Houk,et al.  Synthetic, Mechanistic and Biological Interrogation of Ginkgo biloba Chemical Space en route to (-)-Bilobalide. , 2020, Journal of the American Chemical Society.

[7]  K. B. Wiberg,et al.  Total Synthesis of (±)-Phyllantidine: Development and Mechanistic Evaluation of a Novel Ring Expansion for Installation of Embedded Nitrogen-Oxygen Bonds. , 2020, Angewandte Chemie.

[8]  A. Echavarren,et al.  Acetylene as a Dicarbene Equivalent for Gold(I) Catalysis: Total Synthesis of Waitziacuminone in One Step , 2020, Angewandte Chemie.

[9]  B. Plietker,et al.  β-Ketoesters as Mono- or Bisnucleophiles: A Concise Enantioselective Total Synthesis of (-)-Englerin A and B. , 2019, Angewandte Chemie.

[10]  J. L. Wood,et al.  Total Synthesis of Caesalpinnone A and Caesalpinflavan B: Evolution of a Concise Strategy. , 2019, Journal of the American Chemical Society.

[11]  G. Trevitt,et al.  Total Synthesis of (±)-Englerin A and Its Tuncated Analogues , 2019, European Journal of Organic Chemistry.

[12]  J. L. Wood,et al.  Total Synthesis of Herquline B and C. , 2019, Journal of the American Chemical Society.

[13]  Pradipta Das,et al.  A Survey of the Structures of US FDA Approved Combination Drugs. , 2018, Journal of medicinal chemistry.

[14]  J. L. Wood,et al.  Total synthesis of cyclopiamide A and speradine E , 2018, Tetrahedron.

[15]  J. T. Njardarson,et al.  From Oxiranes to Oligomers: Architectures of U.S. FDA Approved Pharmaceuticals Containing Oxygen Heterocycles. , 2018, Journal of medicinal chemistry.

[16]  Yu‐Wen Huang,et al.  Total Synthesis of (+)- and (±)-Hosieine A. , 2018, Angewandte Chemie.

[17]  Yutao Cui,et al.  Total Syntheses of (-)-Englerins A/B, (+)-Orientalols E/F, and (-)-Oxyphyllol. , 2018, Organic letters.

[18]  Aaron A. Bedermann,et al.  Total Synthesis of (±)-Phomoidride D. , 2018, Angewandte Chemie.

[19]  M. Beller,et al.  Photo- and Electrochemical Valorization of Carbon Dioxide Using Earth-Abundant Molecular Catalysts , 2018, Topics in Current Chemistry.

[20]  J. L. Wood,et al.  Total Synthesis of (±)-Aspergilline A. , 2017, Journal of the American Chemical Society.

[21]  William H. Green,et al.  Computer-Assisted Retrosynthesis Based on Molecular Similarity , 2017, ACS central science.

[22]  J. L. Wood,et al.  Total Syntheses of (+)- and (-)-Tetrapetalones A and C. , 2017, Journal of the American Chemical Society.

[23]  J. Mascareñas,et al.  Concise, Enantioselective, and Versatile Synthesis of (-)-Englerin A Based on a Platinum-Catalyzed [4C+3C] Cycloaddition of Allenedienes. , 2016, Angewandte Chemie.

[24]  B. Linclau,et al.  Total Synthesis of (-)-Luminacin D. , 2016, The Journal of organic chemistry.

[25]  Thomas Böttcher,et al.  An Additive Definition of Molecular Complexity , 2016, J. Chem. Inf. Model..

[26]  J. L. Wood,et al.  Collaborative Total Synthesis: Routes to (±)-Hippolachnin A Enabled by Quadricyclane Cycloaddition and Late-Stage C-H Oxidation. , 2016, Journal of the American Chemical Society.

[27]  Kento Ishida,et al.  Total Synthesis of (±)-Englerin A Using An Intermolecular [3+2] Cycloaddition Reaction of Platinum-Containing Carbonyl Ylide. , 2016, Chemistry, an Asian journal.

[28]  N. Shimada,et al.  Asymmetric Total Synthesis of (-)-Englerin A through Catalytic Diastereo- and Enantioselective Carbonyl Ylide Cycloaddition. , 2015, Chemistry.

[29]  J. T. Njardarson,et al.  Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals. , 2014, Journal of medicinal chemistry.

[30]  J. T. Njardarson,et al.  Beyond C, H, O, and N! Analysis of the elemental composition of U.S. FDA approved drug architectures. , 2014, Journal of medicinal chemistry.

[31]  J. T. Njardarson,et al.  Data-mining for sulfur and fluorine: an evaluation of pharmaceuticals to reveal opportunities for drug design and discovery. , 2014, Journal of medicinal chemistry.

[32]  W. Peng,et al.  Total synthesis of (−)-Englerin A , 2014 .

[33]  J. T. Njardarson,et al.  An In-Pharm-ative Educational Poster Anthology Highlighting the Therapeutic Agents That Chronicle Our Medicinal History , 2013 .

[34]  J. L. Wood,et al.  An enantioselective total synthesis and stereochemical revision of (+)-citrinadin B. , 2013, Journal of the American Chemical Society.

[35]  P. Wender Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis. , 2013, Tetrahedron.

[36]  P. Metz,et al.  A short enantioselective total synthesis of (-)-englerin A. , 2013, Angewandte Chemie.

[37]  John R. Proudfoot,et al.  Reaction Schemes Visualized in Network Form: The Syntheses of Strychnine as an Example , 2013, J. Chem. Inf. Model..

[38]  J. L. Wood,et al.  Total syntheses of (±)-securinine and (±)- allosecurinine. , 2012, Organic letters.

[39]  S. Hatakeyama,et al.  Stereocontrolled total synthesis of (-)-englerin A. , 2012, The Journal of organic chemistry.

[40]  P. Gao,et al.  A reductive-Heck approach to the hydroazulene ring system: a formal synthesis of the englerins. , 2012, Organic letters.

[41]  J. T. Njardarson,et al.  Chemistry By Design: A Web-Based Educational Flashcard for Exploring Synthetic Organic Chemistry , 2012 .

[42]  K. A. Parker,et al.  A formal synthesis of (-)-englerin A by relay ring closing metathesis and transannular etherification. , 2012, Organic letters.

[43]  R. Fröhlich,et al.  Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile. , 2011, Angewandte Chemie.

[44]  William J. Chain,et al.  A brief synthesis of (-)-englerin A. , 2011, Journal of the American Chemical Society.

[45]  Nicholas A. McGrath,et al.  A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives , 2010 .

[46]  Jing Xu,et al.  Enantioselective formal synthesis of (-)-englerin A via a Rh-catalyzed [4 + 3] cycloaddition reaction. , 2010, Organic letters.

[47]  Phil S Baran,et al.  Aiming for the ideal synthesis. , 2010, The Journal of organic chemistry.

[48]  K. Nicolaou,et al.  Total synthesis of englerin A. , 2010, Journal of the American Chemical Society.

[49]  Qianghui Zhou,et al.  Asymmetric, protecting-group-free total synthesis of (-)-englerin A. , 2010, Angewandte Chemie.

[50]  Kian Molawi,et al.  Enantioselective synthesis of (-)-englerins A and B. , 2010, Angewandte Chemie.

[51]  Phil S. Baran,et al.  The economies of synthesis. , 2009, Chemical Society reviews.

[52]  Benjamin L. Miller,et al.  Synthesis at the molecular frontier , 2009, Nature.

[53]  P. Baran,et al.  Protecting-group-free synthesis as an opportunity for invention. , 2009, Nature chemistry.

[54]  K. Gustafson,et al.  Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. , 2009, Organic letters.

[55]  R. W. Hoffmann,et al.  Redox economy in organic synthesis. , 2009, Angewandte Chemie.

[56]  Paul A Wender,et al.  Function-oriented synthesis, step economy, and drug design. , 2008, Accounts of chemical research.

[57]  S. Reisman,et al.  Total synthesis of (+/-)-welwitindolinone a isonitrile. , 2006, Journal of the American Chemical Society.

[58]  T. Maruyama,et al.  Total synthesis of ingenol. , 2004, Journal of the American Chemical Society.

[59]  G. Keaney,et al.  Total synthesis of (+/-)-kalihinol C. , 2004, Organic letters.

[60]  Steven H. Bertz,et al.  Complexity of synthetic reactions. The use of complexity indices to evaluate reactions, transforms and disconnections , 2003 .

[61]  J. L. Wood,et al.  Reactive enols in synthesis 2. Synthesis of (+)-latifolic acid and (+)-latifoline. , 2001, The Journal of organic chemistry.

[62]  J. L. Wood,et al.  Total synthesis of (+/-)-epoxysorbicillinol. , 2001, Journal of the American Chemical Society.

[63]  René Barone,et al.  A New and Simple Approach to Chemical Complexity. Application to the Synthesis of Natural Products , 2001, J. Chem. Inf. Comput. Sci..

[64]  René Barone,et al.  Information Theory Description of Synthetic Strategies in the Polyquinane Series. The Holosynthon Concept , 1998 .

[65]  H. W. Whitlock,et al.  On the Structure of Total Synthesis of Complex Natural Products , 1998 .

[66]  B. Stoltz,et al.  TOTAL SYNTHESIS OF (+)-RK-286C, (+)-MLR-52, (+)-STAUROSPORINE, AND (+)-K252A , 1996 .

[67]  B. Stoltz,et al.  Total Synthesis of (+)- and (-)-K252a , 1995 .

[68]  Barry M. Trost,et al.  Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way , 1995 .

[69]  J. L. Wood,et al.  Total Syntheses of (+)- and (-)-Syringolides , 1995 .

[70]  B. Trost,et al.  The atom economy--a search for synthetic efficiency. , 1991, Science.

[71]  E. Corey,et al.  The Logic of Chemical Synthesis: Multistep Synthesis of Complex Carbogenic Molecules (Nobel Lecture)† , 1991 .

[72]  Ping Huang,et al.  Molecular complexity: a simplified formula adapted to individual atoms , 1987, J. Chem. Inf. Comput. Sci..

[73]  Steven H. Bertz,et al.  The first general index of molecular complexity , 1981 .

[74]  S. Hanessian Approaches to the total synthesis of natural products using "chiral templates" derived from carbohydrates , 1979 .

[75]  J. B. Hendrickson,et al.  Systematic synthesis design. IV. Numerical codification of construction reactions , 1975 .

[76]  R. Woodward,et al.  The total synthesis of vitamin B12 , 1973, Pure and applied chemistry. Chimie pure et appliquee.

[77]  R. Woodward,et al.  The Total Synthesis of Cephalosporin C1 , 1966 .

[78]  R. Woodward,et al.  THE TOTAL SYNTHESIS OF RESERPINE , 1956 .

[79]  R. Woodward,et al.  The Total Synthesis of Quinine , 1945 .