Central β-adrenergic modulation of cognitive flexibility

Situational stressors and anxiety impede performance on creativity tests requiring cognitive flexibility. Preliminary research revealed better performance on a task requiring cognitive flexibility, the anagram task, after propranolol (beta-adrenergic antagonist) than after ephedrine (beta-adrenergic agonist). However, propranolol and ephedrine have both peripheral and central beta-adrenergic effects. In order to determine whether noradrenergic modulation of cognitive flexibility is a centrally or peripherally mediated phenomenon, we compared the effects of propranolol (peripheral and central beta-blocker), nadolol (peripheral beta-blocker), and placebo on anagram task performance. Solution latency scores for each subject were compared across the drug conditions. Anagram solution latency scores after propranolol were significantly lower than after nadolol. This suggests a centrally mediated modulatory influence of the noradrenergic system on cognitive flexibility.

[1]  S. Mednick.  The associative basis of the creative process. , 1962, Psychological review.

[2]  G. A. Mendelsohn,et al.  DIFFERENTIAL USE OF INCIDENTAL STIMULI IN PROBLEM SOLVING AS A FUNCTION OF CREATIVITY. , 1964, Journal of abnormal psychology.

[3]  C. Martindale,et al.  The differential effect of increased arousal on creative and intellectual performance. , 1973, The Journal of genetic psychology.

[4]  D. Goldstein,et al.  Stressor specificity of peripheral catecholaminergic activation. , 1998, Advances in pharmacology.

[5]  Jerry Tomasini.  Effect of Peer-Induced Anxiety on a Problem-Solving Task , 1973, Psychological reports.

[6]  D. Redmond,et al.  CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS , 1978, The Lancet.

[7]  Lynette J. Tippett,et al.  Effects of focal brain lesions on visual problem-solving , 1996, Neuropsychologia.

[8]  R. Cattell.  Theory of fluid and crystallized intelligence: A critical experiment. , 1963 .

[9]  A. Damasio.  The somatic marker hypothesis and the possible functions of the prefrontal cortex. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[10]  Margaret A. Chesney,et al.  Epinephrine and Norepinephrine Responses in Continuously Collected Human Plasma to a Series of Stressors , 1983, Psychosomatic medicine.

[11]  K M Heilman,et al.  Increased discrimination of "false memories" in autism spectrum disorder. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[12]  M. Hasselmo,et al.  Noradrenergic suppression of synaptic transmission may influence cortical signal-to-noise ratio. , 1997, Journal of neurophysiology.

[13]  H. Faigel.  The Effect of Beta Blockade on Stress-Induced Cognitive Dysfunction in Adolescents , 1991, Clinical pediatrics.

[14]  Relationship of Anagram Solving to Measures of Divergent-Production and Letter-Rearrangement Ability , 1975 .

[15]  C. McDougle,et al.  Noradrenergic dysregulation during discontinuation of cocaine use in addicts. , 1994, Archives of general psychiatry.

[16]  M. Dey.  Anagram solution speed as a joint function of manifest anxiety and number of category sets. , 1978, The American journal of psychology.

[17]  J. Cohen,et al.  The role of locus coeruleus in the regulation of cognitive performance. , 1999, Science.

[18]  K M Heilman,et al.  Noradrenergic modulation of cognitive flexibility in problem solving. , 1999, Neuroreport.

[19]  S. Nader.  Letter: Storage and transport of serum for prolactin radioimmunoassay. , 1974, Lancet.

[20]  R. Ehrman,et al.  Open trials as a method of prioritizing medications for inclusion in controlled trials for cocaine dependence. , 1999, Addictive behaviors.

[21]  Discriminant and Concurrent Validity of Two Commonly Used Measures of Test Anxiety , 1982 .

[22]  M. Conway,et al.  Individual differences in nonconscious processing: The role of creativity , 1990 .

[23]  Bernard L. Hinton,et al.  Environmental frustration and creative problem solving. , 1968, The Journal of applied psychology.

[24]  B. W. Harleston,et al.  TEST-ANXIETY LEVEL, HEART RATE, AND ANAGRAM PROBLEM SOLVING. , 1965, Journal of personality and social psychology.

[25]  M. Spitzer,et al.  Dopaminergic modulation of semantic network activation , 1996, Neuropsychologia.