Understanding the Molecular Regulation of Serotonin Receptor 5-HTR_1B-β-Arrestin1 Complex in Stress and Anxiety Disorders

[1]  Di Peng,et al.  GPS 6.0: an updated server for prediction of kinase-specific phosphorylation sites in proteins , 2023, Nucleic Acids Res..

[2]  Linfu Yang,et al.  The significance of Apis cerana cerana (Hymenoptera: Apidae) gnawing off the old brood cells , 2023, Apidologie.

[3]  R. Depoortère,et al.  The 5-HT1A receptor biased agonist, NLX-204, shows rapid-acting antidepressant-like properties and neurochemical changes in two mouse models of depression , 2022, Behavioural Brain Research.

[4]  G. Makhatadze Faculty Opinions recommendation of Accurate prediction of protein structures and interactions using a three-track neural network. , 2021, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[5]  K. Pal,et al.  miRNA regulation of G protein-coupled receptor mediated angiogenic pathways in cancer , 2021, The Nucleus.

[6]  Eric W. Bell,et al.  Folding non-homologous proteins by coupling deep-learning contact maps with I-TASSER assembly simulations , 2021, Cell reports methods.

[7]  M. Kołaczkowski,et al.  The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress , 2021, Psychopharmacology.

[8]  F. Gao,et al.  Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2 , 2021, Nature Communications.

[9]  Peter B. McGarvey,et al.  UniProt: the universal protein knowledgebase in 2021 , 2020, Nucleic Acids Res..

[10]  Lan-Ying Huang,et al.  GasPhos: Protein Phosphorylation Site Prediction Using a New Feature Selection Approach with a GA-Aided Ant Colony System , 2020, International journal of molecular sciences.

[11]  Duolin Wang,et al.  MusiteDeep: a deep-learning based webserver for protein post-translational modification site prediction and visualization , 2020, Nucleic Acids Res..

[12]  Jun Yao,et al.  Functional polymorphisms and transcriptional analysis in the 5′ region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders , 2020, BMC Psychiatry.

[13]  Nyasha Gondora GPCR and RTK Regulation in Neurons: The Impact of Stress on GPCR and RTK signalling and Crosstalk , 2020 .

[14]  Yu Xue,et al.  GPS 5.0: An Update on the Prediction of Kinase-specific Phosphorylation Sites in Proteins , 2020, Genom. Proteom. Bioinform..

[15]  Hideaki E. Kato,et al.  Structure of the Neurotensin Receptor 1 in complex with β-arrestin 1 , 2020, Nature.

[16]  Candidate Gene , 2019, Definitions.

[17]  H. Xu,et al.  A complex structure of arrestin-2 bound to a G protein-coupled receptor , 2019, Cell Research.

[18]  V. Gurevich,et al.  GPCR Signaling Regulation: The Role of GRKs and Arrestins , 2019, Front. Pharmacol..

[19]  N. Pivac,et al.  The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse , 2019, Neuropsychiatric disease and treatment.

[20]  Mateusz Kurcinski,et al.  CABS-flex standalone: a simulation environment for fast modeling of protein flexibility , 2018, Bioinform..

[21]  B. Bryan,et al.  5-HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability , 2018, Molecular and clinical oncology.

[22]  J. García-Nafría,et al.  Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go , 2018, Nature.

[23]  Torsten Schwede,et al.  SWISS-MODEL: homology modelling of protein structures and complexes , 2018, Nucleic Acids Res..

[24]  Y. Okubo,et al.  The 5-HT1B receptor - a potential target for antidepressant treatment , 2018, Psychopharmacology.

[25]  Y. Okubo,et al.  The 5-HT1B receptor - a potential target for antidepressant treatment , 2018, Psychopharmacology.

[26]  Weimin Cai,et al.  HTR1A/1B DNA methylation may predict escitalopram treatment response in depressed Chinese Han patients. , 2018, Journal of affective disorders.

[27]  Mateusz Kurcinski,et al.  CABS-flex 2.0: a web server for fast simulations of flexibility of protein structures , 2018, Nucleic Acids Res..

[28]  M. von Zastrow,et al.  Subcellular Organization of GPCR Signaling. , 2018, Trends in pharmacological sciences.

[29]  Yanchun Liang,et al.  MusiteDeep: a deep‐learning framework for general and kinase‐specific phosphorylation site prediction , 2017, Bioinform..

[30]  P. Xiao,et al.  Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model , 2017, Molecular Pharmacology.

[31]  Meryem Köse GPCRs and EGFR - Cross-talk of membrane receptors in cancer. , 2017, Bioorganic & medicinal chemistry letters.

[32]  Naomi R. Latorraca,et al.  Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors , 2017, Cell.

[33]  P. Svenningsson,et al.  Distribution and levels of 5-HT1B receptors in anterior cingulate cortex of patients with bipolar disorder, major depressive disorder and schizophrenia – An autoradiography study , 2017, European Neuropsychopharmacology.

[34]  Kathryn A. Porter,et al.  The ClusPro web server for protein–protein docking , 2017, Nature Protocols.

[35]  The UniProt Consortium UniProt: the universal protein knowledgebase , 2016, Nucleic Acids Res..

[36]  Wei Chen,et al.  Prediction of phosphothreonine sites in human proteins by fusing different features , 2016, Scientific Reports.

[37]  R. Rodriguiz,et al.  Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice , 2016, Neuropsychopharmacology.

[38]  R. Lipton,et al.  Migraine and its psychiatric comorbidities , 2016, Journal of Neurology, Neurosurgery & Psychiatry.

[39]  Berk Hess,et al.  GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers , 2015 .

[40]  B. Roth,et al.  Structure and function of serotonin G protein-coupled receptors. , 2015, Pharmacology & therapeutics.

[41]  M. Dadds,et al.  Serotonin 1B Receptor Gene (HTR1B) Methylation as a Risk Factor for Callous-Unemotional Traits in Antisocial Boys , 2015, PloS one.

[42]  Kenji F. Tanaka,et al.  Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity , 2015, Neuron.

[43]  Yang Zhang,et al.  I-TASSER server: new development for protein structure and function predictions , 2015, Nucleic Acids Res..

[44]  A. Shukla,et al.  Methodological advances: the unsung heroes of the GPCR structural revolution , 2015, Nature Reviews Molecular Cell Biology.

[45]  Yang Zhang,et al.  The I-TASSER Suite: protein structure and function prediction , 2014, Nature Methods.

[46]  Garth J. Williams,et al.  Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser , 2014, Nature.

[47]  Zhiping Weng,et al.  ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers , 2014, Bioinform..

[48]  Andrzej Kolinski,et al.  CABS-flex predictions of protein flexibility compared with NMR ensembles , 2014, Bioinform..

[49]  Yongchao Dou,et al.  PhosphoSVM: prediction of phosphorylation sites by integrating various protein sequence attributes with a support vector machine , 2014, Amino Acids.

[50]  H. Xu,et al.  Structure Modeling Using Genetically Engineered Crosslinking , 2013, Cell.

[51]  T. Lehtimäki,et al.  Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study , 2013, Journal of Behavioral Medicine.

[52]  R. Hen,et al.  A method for biomarker measurements in peripheral blood mononuclear cells isolated from anxious and depressed mice: β-arrestin 1 protein levels in depression and treatment , 2013, Front. Pharmacol..

[53]  Carles Pons,et al.  pyDockWEB: a web server for rigid-body protein-protein docking using electrostatics and desolvation scoring , 2013, Bioinform..

[54]  Andrzej Kolinski,et al.  CABS-flex: server for fast simulation of protein structure fluctuations , 2013, Nucleic Acids Res..

[55]  Hualiang Jiang,et al.  Structural Basis for Molecular Recognition at Serotonin Receptors , 2013, Science.

[56]  Benjamin D. Sachs,et al.  Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model , 2013, Cell cycle.

[57]  R. Stevens,et al.  Structure-function of the G protein-coupled receptor superfamily. , 2013, Annual review of pharmacology and toxicology.

[58]  Wenhua Zheng,et al.  The possible role of the Akt signaling pathway in schizophrenia , 2012, Brain Research.

[59]  Lusheng Wang,et al.  Protein-protein binding site identification by enumerating the configurations , 2012, BMC Bioinformatics.

[60]  Krzysztof Palczewski,et al.  The Significance of G Protein-Coupled Receptor Crystallography for Drug Discovery , 2011, Pharmacological Reviews.

[61]  J. Neumaier,et al.  5-HT1B mRNA expression after chronic social stress , 2011, Behavioural Brain Research.

[62]  D. Higgins,et al.  Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega , 2011, Molecular systems biology.

[63]  J. Simms,et al.  Lifting the lid on GPCRs: the role of extracellular loops , 2011, British journal of pharmacology.

[64]  S. Rasmussen,et al.  Crystal Structure of the β2Adrenergic Receptor-Gs protein complex , 2011, Nature.

[65]  A. Sokolov,et al.  The role of serotonin receptors in migraine headaches , 2011, Neurochemical Journal.

[66]  A. Székely,et al.  Candidate gene studies of dopaminergic and serotonergic polymorphisms. , 2011, Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.

[67]  M. Iyo,et al.  Association Between 5HT1b Receptor Gene and Methamphetamine Dependence , 2011, Current neuropharmacology.

[68]  Rebecca Elliott,et al.  The HTR1A and HTR1B receptor genes influence stress-related information processing , 2011, European Neuropsychopharmacology.

[69]  S. Gygi,et al.  Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR) , 2010, Proceedings of the National Academy of Sciences.

[70]  W. Becker,et al.  The Stress and Migraine Interaction , 2009, Headache.

[71]  F. Sheftell,et al.  Stress and Migraine , 2009, Headache.

[72]  Torsten Schwede,et al.  Automated comparative protein structure modeling with SWISS‐MODEL and Swiss‐PdbViewer: A historical perspective , 2009, Electrophoresis.

[73]  S. Rasmussen,et al.  The structure and function of G-protein-coupled receptors , 2009, Nature.

[74]  B. Roth,et al.  The expanded biology of serotonin. , 2009, Annual review of medicine.

[75]  R. Gainetdinov,et al.  Akt/GSK3 signaling in the action of psychotropic drugs. , 2009, Annual review of pharmacology and toxicology.

[76]  A. Meyer-Lindenberg,et al.  Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. , 2008, The Journal of clinical investigation.

[77]  S. Gwaltney-Brant,et al.  Serotonin: a review. , 2008, Journal of veterinary pharmacology and therapeutics.

[78]  R. Stevens,et al.  GPCR Engineering Yields High-Resolution Structural Insights into β2-Adrenergic Receptor Function , 2007, Science.

[79]  R. Lefkowitz,et al.  Seven transmembrane receptors: something old, something new , 2007, Acta physiologica.

[80]  R. Hargreaves New Migraine and Pain Research , 2007, Headache.

[81]  Ruth Nussinov,et al.  PatchDock and SymmDock: servers for rigid and symmetric docking , 2005, Nucleic Acids Res..

[82]  E. Tatarczyńska,et al.  Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression , 2004, Behavioural pharmacology.

[83]  K. D. Tripathi,et al.  Essentials of Medical Pharmacology , 2004 .

[84]  S. Avissar,et al.  Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. , 2004, The American journal of psychiatry.

[85]  David Baker,et al.  Protein structure prediction and analysis using the Robetta server , 2004, Nucleic Acids Res..

[86]  S. Watson,et al.  Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia , 2004, Biological Psychiatry.

[87]  M. Karayiorgou,et al.  Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia , 2004, Nature Genetics.

[88]  C. Dominguez,et al.  HADDOCK: a protein-protein docking approach based on biochemical or biophysical information. , 2003, Journal of the American Chemical Society.

[89]  Ruth Nussinov,et al.  Efficient Unbound Docking of Rigid Molecules , 2002, WABI.

[90]  Bondy Brigitta Pathophysiology of depression and mechanisms of treatment , 2002, Dialogues in clinical neuroscience.

[91]  M Briley,et al.  The possible role of 5-HT(1B/D) receptors in psychiatric disorders and their potential as a target for therapy. , 2000, European journal of pharmacology.

[92]  A. Ullrich,et al.  Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor - convergence point for signal integration and diversification , 2000, Breast Cancer Research.

[93]  J. Launay,et al.  5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[94]  N. Blom,et al.  Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. , 1999, Journal of molecular biology.

[95]  Patrice Gouet,et al.  ESPript: analysis of multiple sequence alignments in PostScript , 1999, Bioinform..

[96]  P. Goadsby,et al.  Serotonin inhibits trigeminal nucleus activity evoked by craniovascular stimulation through a 5ht 1b/1D receptor: A central action in migraine? , 1998, Annals of neurology.

[97]  K Schulten,et al.  VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.

[98]  M. Buhot,et al.  5-HT1B receptor knock out — behavioral consequences , 1995, Behavioural Brain Research.

[99]  T. Yeates,et al.  Verification of protein structures: Patterns of nonbonded atomic interactions , 1993, Protein science : a publication of the Protein Society.

[100]  M. Ferrari,et al.  On Serotonin and Migraine: A Clinical and Pharmacological Review , 1993, Cephalalgia : an international journal of headache.

[101]  J. Thornton,et al.  Stereochemical quality of protein structure coordinates , 1992, Proteins.

[102]  J. Fernández-Recio,et al.  Modeling of Protein Complexes and Molecular Assemblies with pyDock. , 2020, Methods in molecular biology.

[103]  Wei Chen,et al.  iPhoPred: A Predictor for Identifying Phosphorylation Sites in Human Protein , 2019, IEEE Access.

[104]  B. Kobilka,et al.  Structure and dynamics of GPCR signaling complexes , 2017, Nature Structural & Molecular Biology.

[105]  Yusha Liu 5-HT1B Autoreceptors: Molecular Mechanisms and Behavioral Implications , 2014 .

[106]  Shafiqur Rahman The brain as a drug target , 2011 .

[107]  D. Hoyer 5-HT-1B Receptor , 2008 .

[108]  C. Hugh,et al.  MIGRAINE AND ITS , 2005 .

[109]  H. Akil,et al.  Serotonin 5-HT 1 A , 5-HT 1 B , and 5-HT 2 A Receptor mRNA Expression in Subjects with Major Depression , Bipolar Disorder , and Schizophrenia , 2004 .

[110]  Cathy H. Wu,et al.  UniProt: the Universal Protein knowledgebase , 2004, Nucleic Acids Res..

[111]  D. Levinson,et al.  Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression , 2003, Molecular Psychiatry.

[112]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[113]  D Vanderspoel,et al.  GROMACS - A PARALLEL COMPUTER FOR MOLECULAR-DYNAMICS SIMULATIONS , 1993 .