Supercritical Fluid Technology and its Pharmaceutical Applications: A Revisit with Two Decades of Progress

Over the past two decades, supercritical fluid technology has emerged as one of the most important technologies applied in many fields such as cosmetic, food and pharmaceutical. Supercritical fluid extraction process offers numerous advantages such as easy, effective, inexpensive, high quality of solute extraction and environmentally friendly. This mini-review describes the fundamentals of supercritical fluid technology, the function of supercritical fluid as solvent and anti-solvent, mechanism of supercritical fluid, advantages and disadvantages and revisit the application of supercritical fluid technology in pharmaceutical sciences. In-depth discussion with recent examples of extraction of natural products, particle design in drug delivery, preparation on pharmaceutical powder, drug solubilization, inclusion complex, polymer impregnation, liposomal formulations, purification and polymorphism as well as drug extraction analysis are also presented. Key aspects and processing considerations of supercritical fluid technologies are reviewed to assist scientists to generate other related experimental works.

[1]  U. Kompella,et al.  Supercritical Fluid Technology in Pharmaceutical Research , 2013 .

[2]  Géza Horváth,et al.  Comparison of solid dispersions produced by supercritical antisolvent and spray-freezing technologies. , 2009, International journal of pharmaceutics.

[3]  R. Neubert,et al.  Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[4]  H. C. Sousa,et al.  Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives , 2008 .

[5]  E. Ibáñez,et al.  Selective fractionation of carbohydrate complex mixtures by supercritical extraction with CO2 and different co-solvents , 2008 .

[6]  T. Martin,et al.  Preparation of budesonide and budesonide-PLA microparticles using supercritical fluid precipitation technology , 2008, AAPS PharmSciTech.

[7]  S. Hawthorne,et al.  Combined Temperature/Modifier Effects on Supercritical CO2 Extraction Efficiencies of Polycyclic Aromatic Hydrocarbons from Environmental Samples , 1995 .

[8]  Praful Balavant Deshpande,et al.  Supercritical Fluid Technology: Concepts and Pharmaceutical Applications , 2011, PDA Journal of Pharmaceutical Science and Technology.

[9]  F. Giordano,et al.  Supercritical fluid technologies: an innovative approach for manipulating the solid-state of pharmaceuticals. , 2008, Advanced drug delivery reviews.

[10]  Uğur Akman,et al.  Polymer swelling and impregnation using supercritical CO2: A model-component study towards producing controlled-release drugs , 2006 .

[11]  P. York,et al.  Separation processes for organic molecules using SCF Technologies. , 2008, Advanced drug delivery reviews.

[12]  K. Abbas,et al.  A Review on Supercritical Fluid Extraction as New Analytical Method , 2008 .

[13]  U. Kompella,et al.  Preparation of drug delivery systems using supercritical fluid technology. , 2001, Critical reviews in therapeutic drug carrier systems.

[14]  Yi Li,et al.  A continuous RESS process to prepare PLA–PEG–PLA microparticles , 2011 .

[15]  Y. S. Zhang,et al.  Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications , 2017, Advanced healthcare materials.

[16]  O. Catchpole,et al.  Extraction of lipids from a specialist dairy stream , 2008 .

[17]  H. Godoy,et al.  Exploring the selectivity of supercritical CO2 to obtain nonpolar fractions of passion fruit bagasse extracts , 2016 .

[18]  J. Guerrero-Beltrán,et al.  CO2-supercritical extraction, hydrodistillation and steam distillation of essential oil of rosemary (Rosmarinus officinalis) , 2017 .

[19]  L. Manna,et al.  Supercritical solvent impregnation of piroxicam on PVP at various polymer molecular weights , 2009 .

[20]  Ernesto Reverchon,et al.  Nanomaterials and supercritical fluids , 2006 .

[21]  Pankaj Pathak,et al.  Formation and stabilization of ibuprofen nanoparticles in supercritical fluid processing , 2006 .

[22]  I. J. Seabra,et al.  Development of natural-based wound dressings impregnated with bioactive compounds and using supercritical carbon dioxide. , 2011, International journal of pharmaceutics.

[23]  P. York,et al.  Supercritical fluid processing of proteins. I: lysozyme precipitation from organic solution. , 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[24]  Gerd Brunner,et al.  Supercritical fluids: technology and application to food processing , 2005 .

[25]  H. Matos,et al.  Anti-solvent effect in the production of lysozyme nanoparticles by supercritical fluid-assisted atomization processes , 2009 .

[26]  E. Ibáñez,et al.  Use of compressed fluids for sample preparation: food applications. , 2007, Journal of chromatography. A.

[27]  M. Manning,et al.  Controlled release of ionic compounds from poly (l-lactide) microspheres produced by precipitation with a compressed antisolvent , 1997 .

[28]  Á. Ríos,et al.  Supercritical fluid extraction: a critical review of its analytical usefulness , 2004 .

[29]  Mariana S. Costa,et al.  Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs. , 2006, International journal of pharmaceutics.

[30]  C. Queiroga,et al.  Fractionated Extraction Of Saponins From Brazilian Ginseng By Sequential Process Using Supercritical Co2, Ethanol And Water , 2014 .

[31]  F. Sahena,et al.  Application of supercritical CO2 in lipid extraction – A review , 2009 .

[32]  F. Temelli,et al.  Characterization of oat beta-glucan and coenzyme Q10-loaded beta-glucan powders generated by the pressurized gas-expanded liquid (PGX) technology. , 2017, Food research international.

[33]  Michael Türk,et al.  Micronization of pharmaceutical substances by the Rapid Expansion of Supercritical Solutions (RESS): a promising method to improve bioavailability of poorly soluble pharmaceutical agents , 2002 .

[34]  E. Squillante,et al.  Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. , 2004, International journal of pharmaceutics.

[35]  R. Singh,et al.  Supercritical Fluids and the Food Industry. , 2002, Comprehensive reviews in food science and food safety.

[36]  Julius B. Maridable,et al.  Supercritical carbon dioxide-mediated hydrothermal extraction of bioactive compounds from Garcinia Mangostana pericarp , 2016 .

[37]  J. Kriz,et al.  A study of the conditions of the supercritical fluid extraction in the analysis of selected anti-inflammatory drugs in plasma. , 2002, Farmaco.

[38]  Chiehming J. Chang,et al.  Supercritical fluids extraction of Ginkgo ginkgolides and flavonoids , 2002 .

[39]  B. Müller,et al.  Application of aerosol solvent extraction system (ASES) process for preparation of liposomes in a dry and reconstitutable form. , 2006, International journal of pharmaceutics.

[40]  Fariba Dehghani,et al.  Micronization by Rapid Expansion of Supercritical Solutions to Enhance the Dissolution Rates of Poorly Water-Soluble Pharmaceuticals , 2000 .

[41]  Hirofumi Takeuchi,et al.  Particle design of poorly water-soluble drug substances using supercritical fluid technologies. , 2008, Advanced drug delivery reviews.

[42]  B. Buszewski,et al.  Supercritical Fluid Extraction of Bioactive Compounds from Plant Materials. , 2017, Journal of AOAC International.

[43]  K. Otake,et al.  Development of a New Preparation Method of Liposomes Using Supercritical Carbon Dioxide , 2001 .

[44]  York,et al.  Strategies for particle design using supercritical fluid technologies. , 1999, Pharmaceutical science & technology today.

[45]  Vijay Kothari,et al.  Extraction methods for preparation of bioactive plant extracts , 2012 .

[46]  S. M. Mousavi,et al.  Effect of various extraction conditions on the phenolic contents of pomegranate seed oil , 2008 .

[47]  S. R. Ferreira,et al.  Bioactive extracts of orange (Citrus sinensis L. Osbeck) pomace obtained by SFE and low pressure techniques: Mathematical modeling and extract composition , 2010 .

[48]  J. Carroll.  Natural Gas Hydrates: A Guide for Engineers , 2020 .

[49]  Keith D. Bartle,et al.  Supercritical fluid extraction , 2007 .

[50]  K. Byrappa,et al.  Nanoparticles synthesis using supercritical fluid technology - towards biomedical applications. , 2008, Advanced drug delivery reviews.

[51]  Ya‐Ping Sun,et al.  Nanoparticle formation in rapid expansion of water-in-supercritical carbon dioxide microemulsion into liquid solution , 2005 .

[52]  Jun Liu,et al.  Supercritical fluid extraction of flavonoids from Maydis stigma and its nitrite-scavenging ability , 2011 .

[53]  Ram B. Gupta,et al.  Dissolution-rate enhancement of fenofibrate by adsorption onto silica using supercritical carbon dioxide. , 2008, International journal of pharmaceutics.

[54]  Lai Yeng Lee,et al.  Supercritical antisolvent production of biodegradable micro- and nanoparticles for controlled delivery of paclitaxel. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[55]  H. Mishra,et al.  Advent of clean and green technology for preparation of low-cholesterol dairy cream powder: supercritical fluid extraction process , 2018, Food Quality and Safety.

[56]  E. Martínez de la Ossa,et al.  Supercritical Antisolvent Precipitation of Ethyl Cellulose , 2012 .

[57]  G. Perretti,et al.  Supercritical fluid extraction for quality control in beer industry , 2007 .

[58]  M. S. Levy,et al.  The formation of plasmid DNA loaded pharmaceutical powders using supercritical fluid technology. , 2001, Biotechnology and bioengineering.

[59]  Uǧur Akman,et al.  Micronization of Ibuprofen by RESS , 2003 .

[60]  J. Fages,et al.  Maturation of a ketoprofen/β-cyclodextrin mixture with supercritical carbon dioxide , 2007 .

[61]  E. Reverchon,et al.  Micronization of antibiotics by supercritical assisted atomization , 2003 .

[62]  K. Peh,et al.  DEVELOPMENT AND APPLICATION OF SIMPLE HPLC-UV METHOD FOR FLUCONAZOLE QUANTIFICATION IN HUMAN PLASMA , 2012 .

[63]  Manohar Balaraman,et al.  In vitro studies on liposomal amphotericin B obtained by supercritical carbon dioxide-mediated process. , 2007, Nanomedicine : nanotechnology, biology, and medicine.

[64]  L. Manna,et al.  Investigation of the piroxicam/hydroxypropyl-β-cyclodextrin inclusion complexation by means of a supercritical solvent in the presence of auxiliary agents , 2011 .

[65]  Valentino J. Stella,et al.  Rapid expansion from supercritical solutions: application to pharmaceutical processes , 1993 .