Age-Related Variations of Lipid Peroxidation in Cadmium-Treated Rats

Under specific conditions, Cd can induce a prooxidant state in biological systems resulting in the peroxidation of the polyunsaturated fatty acids. We investigated in vivo this phenomenon in major target organs of Long Evans rats (12- and 36-week-old), 24 hours after being injected i.p. with a range of cadmium chloride doses (0.00, 0.05, 0.25, 1.0 or 2.5 mg Cd/kg). The measurements of the thiobarbituric acid reactive substances demonstrated that the lungs showed the highest Cd-induced LPO in the 12-week-old rats even if the liver and kidneys accumulated the greatest amounts of Cd. Cd-induced LPO as measured by TBARS assay in the 36-week-old groups was, in all organs, less pronounced even if the control levels were higher for these groups. The reasons for this age-dependent differences are not clear. Some components of the antioxidant defense system were differently modulated as a function of age. However, it is not certain whether these changes have a causative role in the induction of LPO following Cd exposure.

[1]  R. Guilbaud,et al.  Absence of in vivo lipid peroxidation in CdCl2-treated rats as measured by exhaled pentane. , 1994, Toxicology Letters.

[2]  L. Ji.  Antioxidant enzyme response to exercise and aging. , 1993, Medicine and science in sports and exercise.

[3]  B. Trottier,et al.  Micro method for determination of cadmium in tissues and slurried samples by use of flameless atomic absorption spectrometry , 1992 .

[4]  G. Paradies,et al.  Decreased activity of the phosphate carrier and modification of lipids in cardiac mitochondria from senescent rats. , 1992, The International journal of biochemistry.

[5]  U. Cogan,et al.  Food restriction and membrane fluidity , 1992, Mechanisms of Ageing and Development.

[6]  G. Yegutkin,et al.  Evaluation of age-related changes of physicochemical properties and functional activity of rat adipose plasma membranes and their possible relationship , 1991, Mechanisms of Ageing and Development.

[7]  B. Trottier,et al.  In vitro andin vivo responses of rat tissues to cadmium-induced lipid peroxidation , 1991, Bulletin of environmental contamination and toxicology.

[8]  L. E. Rikans,et al.  Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver. , 1991, Biochimica et biophysica acta.

[9]  B. Trottier,et al.  Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. , 1991, Toxicology.

[10]  D. Nadeau,et al.  A micromethod for the quantitation of cellular proteins in Percoll with the Coomassie brilliant blue dye-binding assay. , 1983, Analytical biochemistry.

[11]  K. Yagi,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. , 1979, Analytical biochemistry.

[12]  M. Fournier,et al.  Recovery potential of hepatocytes from inhibition of albumin secretion by cadmium. , 1993, Journal of toxicology and environmental health.

[13]  K. Koumanov,et al.  Effects of age-dependent or liposome-induced alterations in the phospholipid composition on sphingomyelin biosynthesis in rat liver microsomal and plasma membranes. , 1991, The International journal of biochemistry.

[14]  F. Galletti,et al.  Age related changes in Ca2+ channels in spontaneously hypertensive rats. , 1991, General pharmacology.

[15]  H. Strobel,et al.  Caloric restriction affects liver microsomal monooxygenases differentially in aging male rats. , 1991, Journal of gerontology.

[16]  R. Vincent,et al.  Lipid Peroxidation in Rats Subacutely Exposed to a Low Concentration of Aerosolized Cadmium Chloride , 1991 .

[17]  R. Vincent,et al.  Lipid Peroxidation in Rat Lungs Following an Acute Inhalation Exposure to Cadmium Chloride , 1989 .