Dissipativity theory for nonnegative and compartmental dynamical systems with time delay

Nonnegative and compartmental dynamical system models are derived from mass and energy balance considerations that involve dynamic states whose values are nonnegative. These models are widespread in engineering and life sciences and typically involve the exchange of nonnegative quantities between subsystems or compartments wherein each compartment is assumed to be kinetically homogeneous. However, in many engineering and life science systems, transfers between compartments are not instantaneous and realistic models for capturing the dynamics of such systems should account for material in transit between compartments. Including some information of past system states in the system model leads to infinite-dimensional delay nonnegative dynamical systems. In this paper we develop new notions of dissipativity theory for nonnegative dynamical systems with time delay using linear storage functionals with linear supply rates. These results are then used to develop general stability criteria for feedback interconnections of nonnegative dynamical systems with time delay.

[1]  Fumihiko Kajiya,et al.  Compartmental system analysis: Realization of a class of linear systems with physical constraints , 1977 .

[2]  R. Mohler,et al.  Biological modeling with variable compartmental structure , 1974 .

[3]  Y. Ohta,et al.  Asymptotic behavior of nonlinear compartmental systems: Nonoscillation and stability , 1978 .

[4]  M. Faddy,et al.  Compartmental Analysis in Biology and Medicine, 2nd edition. , 1987 .

[5]  S. Niculescu Delay Effects on Stability: A Robust Control Approach , 2001 .

[6]  Erik I. Verriest,et al.  Stability and Control of Time-delay Systems , 1998 .

[7]  A. Berman,et al.  Nonnegative matrices in dynamic systems , 1979 .

[8]  David H. Anderson Compartmental Modeling and Tracer Kinetics , 1983 .

[9]  Jack K. Hale,et al.  Introduction to Functional Differential Equations , 1993, Applied Mathematical Sciences.

[10]  John A. Jacquez,et al.  Qualitative Theory of Compartmental Systems , 1993, SIAM Rev..

[11]  R. E. Funderlic,et al.  Solution of Homogeneous Systems of Linear Equations Arising from Compartmental Models , 1981 .

[12]  Y. Ohta,et al.  Reachability, Observability, and Realizability of Continuous-Time Positive Systems , 1984 .

[13]  Wassim M. Haddad,et al.  Stability and dissipativity theory for nonnegative dynamical systems: a thermodynamic framework for biological and physiological systems , 2001, Proceedings of the 40th IEEE Conference on Decision and Control (Cat. No.01CH37228).

[14]  D. Bernstein,et al.  Compartmental modelling and second-moment analysis of state space systems , 1993 .

[15]  J. Jacquez Compartmental analysis in biology and medicine , 1985 .

[16]  Keith Godfrey,et al.  Compartmental Models and Their Application , 1983 .

[17]  J. Willems Dissipative dynamical systems part I: General theory , 1972 .

[18]  Irwin W. Sandberg,et al.  On the mathematical foundations of compartmental analysis in biology, medicine, and ecology , 1978 .

[19]  Robert J. Plemmons,et al.  Nonnegative Matrices in the Mathematical Sciences , 1979, Classics in Applied Mathematics.