Effect of granulocyte-macrophage colony-stimulating growth factor on interferon and tumor necrosis factor production in whole blood cell cultures of patients with acute myelogenous leukemia.

The effect of recombinat human granulocyte-macrophage colony-stimulating growth factor (rHuGM-CSF) treatment on in vitro interferon (IFN) and tumor necrosis factor (TNF) production in peripheral blood cells of 46 patients with acute myelogenous leukemia (AML) was examined. GM-CSF significantly enhanced virus-induced IFN-alpha production in blood cells (containing 68% of blasts) of 28 patients with M4-M5 AML according to the French-American-British (FAB) classification and also phytohemagglutinin (PHA)-induced IFN-gamma production in blood cells (containing 70% of blasts) of 18 patients with AML MO-M3 type. In control blood cells (25 healthy persons) GM-CSF enhanced PHA-induced IFN-gamma but did not influence IFN-alpha production. In the presence of GM-CSF, TNF-alpha titers induced with lipopolysaccharide were also higher in control blood cells but not in cells of patients with M0-M3 or M4-M5 type of AML. The significance of GM-CSF-enhanced IFN-alpha and IFN-gamma production in antimicrobial and anti-leukemic immune reactions which can develop during GM-CSF therapy is discussed.

[1]  R. Stone.  Hematopoietic Growth Factors in Acute Leukemia , 1999 .

[2]  J. Rowe,et al.  Hematopoietic growth factors and acute leukemia. , 1999, Cancer treatment and research.

[3]  H. Drexler,et al.  Interferon‐gamma induced proliferation of human myeloid leukaemia cell lines , 1997, British journal of haematology.

[4]  H. Lahm,et al.  Tumour-derived, endocrine, exogenous and therapeutic factors differentially modulate cytokine secretion in whole blood cell culture. , 1997, European journal of cancer.

[5]  H. Quentmeier,et al.  Cytokine response profiles of human myeloid factor-dependent leukemia cell lines , 1997, Leukemia.

[6]  R. Geller,et al.  Use of cytokines in the treatment of acute myelocytic leukemia: a critical review. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  C. Wiltschke,et al.  Influence of in vivo administration of GM-CSF and G-CSF on monocyte cytotoxicity. , 1995, Experimental hematology.

[8]  J. Armitage,et al.  Clinical applications of hematopoietic growth factors. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  Ø. Bruserud,et al.  Cytokine modulation of interleukin 1 and tumour necrosis factor-alpha secretion from acute myelogenous leukaemia blast cells in vitro. , 1995, Leukemia research.

[10]  K. Remes,et al.  Spontaneous remission in acute myeloid leukaemia , 1994, British journal of haematology.

[11]  P M Guyre,et al.  Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3. , 1993, Journal of immunology.

[12]  S. Tomoyasu,et al.  The role of granulocyte-macrophage colony-stimulating factor in induction of monocytic differentiation of HL-60 cells: synergistic interaction with 1 alpha, 25-dihydroxyvitamin D3 and interferon-gamma in inducing interleukin-1 beta. , 1992, Anticancer research.

[13]  A. Carter,et al.  Effect of interleukin‐1, tumor necrosis factor‐α, and interferon‐α on the blast cells of acute myeloblastic leukemia , 1992 .

[14]  N. Hogg,et al.  The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors. , 1989, Journal of immunology.

[15]  R. Craig,et al.  Differentiation‐inducing and cytotoxic effects of tumor necrosis factor and interferon‐gamma in myeloblastic ML‐1 cells , 1989, Journal of cellular physiology.

[16]  A. Haman,et al.  Tumor necrosis factor alpha stimulates the growth of the clonogenic cells of acute myeloblastic leukemia in synergy with granulocyte/macrophage colony-stimulating factor , 1989, The Journal of experimental medicine.

[17]  E. Ikkala,et al.  Spontaneous remission in acute myeloid leukaemia. , 1982, Acta haematologica.