Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice

[1]  F. Liu,et al.  The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism , 2019, Diabetes.

[2]  P. J. Kranzusch,et al.  Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA , 2019, Cell.

[3]  N. Manel,et al.  The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus , 2019, Cell reports.

[4]  Yongsheng Yu,et al.  STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis , 2018, The Journal of clinical investigation.

[5]  H. Funabiki,et al.  The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death , 2019, Cell.

[6]  Qifu Li,et al.  Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice. , 2018, Gastroenterology.

[7]  S. Kaufmann,et al.  Nuclear cGAS suppresses DNA repair and promotes tumorigenesis , 2018, Nature.

[8]  E. Major,et al.  Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis , 2018, Proceedings of the National Academy of Sciences.

[9]  Zhijian J. Chen,et al.  The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer , 2018, The Journal of experimental medicine.

[10]  Kit-San Yuen,et al.  A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing , 2018, Nucleic acids research.

[11]  K. Rogers,et al.  BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis , 2018, Science.

[12]  Jieun Lee,et al.  Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing , 2017, Molecular metabolism.

[13]  Samir Guglani.  Death , 1890, The Lancet.

[14]  B. Kuster,et al.  The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity , 2017, Cell reports.

[15]  F. Liu,et al.  DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway , 2017, Proceedings of the National Academy of Sciences.

[16]  S. Kajimura,et al.  UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis , 2017, Nature Medicine.

[17]  M. Blüher,et al.  The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue , 2017, Nature Medicine.

[18]  Zhijian J. Chen,et al.  Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing , 2016, Nature Immunology.

[19]  Mark Ellisman,et al.  NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria , 2016, Cell.

[20]  B. Spiegelman,et al.  A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat , 2015, Cell.

[21]  M. Cooper,et al.  Role of Energy Metabolism in the Brown Fat Gene Program , 2015, Front. Endocrinol..

[22]  L. Rubin,et al.  Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes , 2015, Nature Medicine.

[23]  J. Ellis,et al.  Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation. , 2015, Cell reports.

[24]  R. Means,et al.  Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response , 2014, Nature.

[25]  T. Taniguchi,et al.  Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA , 2014, Cell.

[26]  Matthew E. Ritchie,et al.  Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production , 2014, Cell.

[27]  Feng Liu,et al.  Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. , 2014, Cell metabolism.

[28]  D. Metzger,et al.  LSD1 promotes oxidative metabolism of white adipose tissue , 2014, Nature Communications.

[29]  A. Saltiel,et al.  Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1 , 2013, eLife.

[30]  P. Seale,et al.  Brown and beige fat: development, function and therapeutic potential , 2013, Nature Medicine.

[31]  K. Horie-Inoue,et al.  A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle , 2013, Nature Communications.

[32]  Zhijian J. Chen,et al.  Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.

[33]  B. Spiegelman,et al.  Adaptive thermogenesis in adipocytes: is beige the new brown? , 2013, Genes & development.

[34]  Jennifer R. Davies,et al.  Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome. , 2012, Human molecular genetics.

[35]  F. Liu,et al.  Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance , 2012, Diabetes.

[36]  M. S. Fernández-García,et al.  Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice , 2012, The EMBO journal.

[37]  Alexander S. Banks,et al.  The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). , 2011, Molecular cell.

[38]  Feng Liu,et al.  A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization , 2008, Proceedings of the National Academy of Sciences.

[39]  B. Spiegelman,et al.  Modulation of PGC-1 Coactivator Pathways in Brown Fat Differentiation through LRP130* , 2008, Journal of Biological Chemistry.

[40]  H. Sul,et al.  Regulation of lipolysis in adipocytes. , 2007, Annual review of nutrition.

[41]  Q. Tong,et al.  SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes* , 2005, Journal of Biological Chemistry.

[42]  Guo-Ping Zhou,et al.  Triggering the Interferon Antiviral Response Through an IKK-Related Pathway , 2003, Science.

[43]  B. Ketterer,et al.  A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes. , 1991, The Biochemical journal.

[44]  D. Ukena,et al.  Zardaverine as a selective inhibitor of phosphodiesterase isozymes. , 1991, Biochemical pharmacology.