Abstract The DEMO Oriented NEutron Source (DONES) is the dedicated facility for testing and enabling of the qualification for different materials to be utilized in the future fusion reactor DEMO. The neutron irradiation damages not only the material samples to be tested but also impacts the plant hardware in and around the Test Cell which makes regular maintenance mandatory. In order to keep the plant availability high, a short as possible downtime for maintenance is the overarching goal. Logistics helps enabling this with analyzing the flow of parts and components with special emphasis on the building layout, suggest improvements and optimization potentials. Transportation processes are then modelled and simulated to find an optimum. Taking into account warehouse locations and spare part policy, realization may lead to an optimum Availability-to-Cost-Ratio from the logistics point of view. In this paper an overview on the different methods of logistics optimization, the individual approaches and goals as well as on their interdependencies is given. Input and output data, boundary conditions, description of the process of integration complement the paper.