Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling.

[1]  D. Jackson,et al.  Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization* , 2016, The Journal of Biological Chemistry.

[2]  Jeffrey A Hubbell,et al.  Engineering growth factors for regenerative medicine applications. , 2016, Acta biomaterialia.

[3]  D. Ferguson,et al.  Neutrophils rapidly transit inflamed lymphatic vessel endothelium via integrin‐dependent proteolysis and lipoxin‐induced junctional retraction , 2015, Journal of leukocyte biology.

[4]  Ronald N. Germain,et al.  Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity , 2015, Cell.

[5]  Mikaël M. Martino,et al.  Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing. , 2015, Advances in wound care.

[6]  Nadège Lagarde,et al.  Isolation of murine lymph node stromal cells. , 2014, Journal of visualized experiments : JoVE.

[7]  M. Swartz,et al.  Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy , 2014, Journal of visualized experiments : JoVE.

[8]  D. Jackson,et al.  Control of dendritic cell trafficking in lymphatics by chemokines , 2014, Angiogenesis.

[9]  M. Swartz,et al.  Emerging roles of lymphatic endothelium in regulating adaptive immunity. , 2014, The Journal of clinical investigation.

[10]  Mikaël M. Martino,et al.  Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing , 2014, Science.

[11]  M. Swartz,et al.  Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis , 2013, Angiogenesis.

[12]  K. Alitalo,et al.  Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways. , 2013, The American journal of pathology.

[13]  Adrian Ranga,et al.  Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix , 2013, Proceedings of the National Academy of Sciences.

[14]  Melody A. Swartz,et al.  Intravital Immunofluorescence for Visualizing the Microcirculatory and Immune Microenvironments in the Mouse Ear Dermis , 2013, PloS one.

[15]  J. Lee,et al.  Extracorporeal Shock Wave Therapy Combined with Vascular Endothelial Growth Factor-C Hydrogel for Lymphangiogenesis , 2012, Journal of Vascular Research.

[16]  W. Kilarski,et al.  An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels , 2012, Angiogenesis.

[17]  D. McDonald,et al.  Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. , 2012, The American journal of pathology.

[18]  W. Olszewski,et al.  Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system , 2012, Indian Journal of Plastic Surgery.

[19]  Ralph Müller,et al.  Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing , 2011, Science Translational Medicine.

[20]  K. Alitalo,et al.  Biological Basis of Therapeutic Lymphangiogenesis , 2011, Circulation.

[21]  D. Mooney,et al.  Growth factor delivery-based tissue engineering: general approaches and a review of recent developments , 2011, Journal of The Royal Society Interface.

[22]  A. Chevailler,et al.  CCR7 is involved in the migration of neutrophils to lymph nodes. , 2011, Blood.

[23]  A. Venugopal,et al.  Nonlinear lymphangion pressure-volume relationship minimizes edema. , 2010, American journal of physiology. Heart and circulatory physiology.

[24]  W. Kilarski,et al.  A new mechanism of blood vessel growth - hope for new treatment strategies. , 2009, Discovery medicine.

[25]  W. Kilarski,et al.  Biomechanical regulation of blood vessel growth during tissue vascularization , 2009, Nature Medicine.

[26]  P. Janmey,et al.  Fibrin gels and their clinical and bioengineering applications , 2009, Journal of The Royal Society Interface.

[27]  Antal Rot,et al.  CCR7 and its ligands: balancing immunity and tolerance , 2008, Nature Reviews Immunology.

[28]  M. Sixt,et al.  Rapid leukocyte migration by integrin-independent flowing and squeezing , 2008, Nature.

[29]  K. Alitalo,et al.  Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation , 2007, Nature Medicine.

[30]  Elisabetta Dejana,et al.  Functionally specialized junctions between endothelial cells of lymphatic vessels , 2007, The Journal of experimental medicine.

[31]  Jun Asai,et al.  Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. , 2007, The American journal of pathology.

[32]  D. Hicklin,et al.  Cooperative and redundant roles of VEGFR‐2 and VEGFR‐3 signaling in adult lymphangiogenesis , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[33]  D. Jackson,et al.  An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium , 2006, The Journal of experimental medicine.

[34]  M. Swartz,et al.  Characterization of lymphangiogenesis in a model of adult skin regeneration. , 2006, American journal of physiology. Heart and circulatory physiology.

[35]  Seppo Yla-Herttuala,et al.  Vascular endothelial growth factor-C accelerates diabetic wound healing. , 2006, The American journal of pathology.

[36]  Dai Fukumura,et al.  Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. , 2006, Cancer research.

[37]  Wilhelm Bloch,et al.  Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair. , 2006, The American journal of pathology.

[38]  Federica Boschetti,et al.  Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Melody A. Swartz,et al.  Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro , 2005, Journal of Cell Science.

[40]  M. Skobe,et al.  Overexpression of VEGF-C Causes Transient Lymphatic Hyperplasia but Not Increased Lymphangiogenesis in Regenerating Skin , 2005, Circulation research.

[41]  Seppo Ylä-Herttuala,et al.  Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. , 2005, The Journal of clinical investigation.

[42]  Melody A Swartz,et al.  Interstitial flow differentially stimulates blood and lymphatic endothelial cell morphogenesis in vitro. , 2004, Microvascular research.

[43]  K. Alitalo,et al.  Vascular endothelial growth factor‐C gene therapy restores lymphatic flow across incision wounds , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[44]  K. Alitalo,et al.  Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis , 2004, Nature Medicine.

[45]  Dai Fukumura,et al.  Peritumor Lymphatics Induced by Vascular Endothelial Growth Factor-C Exhibit Abnormal Function , 2004, Cancer Research.

[46]  Jeffrey A. Hubbell,et al.  Cell-Demanded Liberation of VEGF121 From Fibrin Implants Induces Local and Controlled Blood Vessel Growth , 2004, Circulation research.

[47]  D Seliktar,et al.  MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. , 2004, Journal of biomedical materials research. Part A.

[48]  D. McDonald,et al.  Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. , 2003, The American journal of pathology.

[49]  M. Swartz,et al.  Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model. , 2003, American journal of physiology. Heart and circulatory physiology.

[50]  Melody A. Swartz,et al.  Interstitial Flow as a Guide for Lymphangiogenesis , 2003, Circulation research.

[51]  A. Metters,et al.  Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[52]  M. Skobe,et al.  Therapeutic lymphangiogenesis with human recombinant VEGF‐C , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[53]  M. Skobe,et al.  Molecular characterization of lymphatic endothelial cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[54]  T. Veikkola,et al.  Adenoviral VEGF‐C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[55]  B. Hinz,et al.  Myofibroblasts and mechano-regulation of connective tissue remodelling , 2002, Nature Reviews Molecular Cell Biology.

[56]  M. Skobe,et al.  Lymphatic function, lymphangiogenesis, and cancer metastasis , 2001, Microscopy research and technique.

[57]  H. Dvorak,et al.  Angiogenesis Therapy: Amidst the Hype, the Neglected Potential for Serious Side Effects , 2001, Circulation.

[58]  J. Pfeilschifter,et al.  Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. , 2000, The Journal of investigative dermatology.

[59]  R K Jain,et al.  Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation. , 1999, Journal of biomechanics.

[60]  H. Saeki,et al.  Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. , 1999, Journal of immunology.

[61]  K. Alitalo,et al.  Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[62]  Yihai Cao,et al.  Proteolytic processing regulates receptor specificity and activity of VEGF‐C , 1997, The EMBO journal.

[63]  R. Jain,et al.  Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. , 1997, Science.

[64]  K. Alitalo,et al.  VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. , 1996, Development.

[65]  G. Pawelec,et al.  Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background. , 2013, Discover medicine.

[66]  J. Hubbell,et al.  Engineered insulin-like growth factor-1 for improved smooth muscle regeneration. , 2012, Biomaterials.

[67]  J. Hubbell,et al.  Engineered aprotinin for improved stability of fibrin biomaterials. , 2011, Biomaterials.

[68]  M. Swartz,et al.  Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype. , 2009, Cancer research.

[69]  D. Shepro.  Microvascular research : biology and pathology , 2006 .

[70]  Valentin Djonov,et al.  New insights into intussusceptive angiogenesis. , 2005, EXS.

[71]  K. Alitalo,et al.  Short Communication Vascular Endothelial Growth Factor Receptor-3 in Lymphangiogenesis in Wound Healing , 2000 .

[72]  J. Hubbell,et al.  Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. , 1999, Bioconjugate chemistry.