IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis.

[1]  Marco Craveiro,et al.  Glut1-mediated glucose transport regulates HIV infection , 2012, Proceedings of the National Academy of Sciences.

[2]  Claire F Pearson,et al.  IL‐7 determines the homeostatic fitness of T cells by distinct mechanisms at different signalling thresholds in vivo , 2011, European journal of immunology.

[3]  Ian Mcleod,et al.  The Class III Kinase Vps34 Promotes T Lymphocyte Survival through Regulating IL-7Rα Surface Expression , 2011, The Journal of Immunology.

[4]  B. Han,et al.  Ephrinb1 and Ephrinb2 Are Associated with Interleukin-7 Receptor α and Retard Its Internalization from the Cell Surface* , 2011, The Journal of Biological Chemistry.

[5]  L. Bradley,et al.  IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization. , 2011, Journal of autoimmunity.

[6]  Tao Wu,et al.  Efnb1 and Efnb2 Proteins Regulate Thymocyte Development, Peripheral T Cell Differentiation, and Antiviral Immune Responses and Are Essential for Interleukin-6 (IL-6) Signaling* , 2011, The Journal of Biological Chemistry.

[7]  Jonathan S. Paw,et al.  Opposing functions of IL-2 and IL-7 in the regulation of immune responses. , 2011, Cytokine.

[8]  A. Ferrando,et al.  Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia , 2011, Nature Genetics.

[9]  P. Lapinski,et al.  A Role for p120 RasGAP in Thymocyte Positive Selection and Survival of Naive T Cells , 2011, The Journal of Immunology.

[10]  Haikun Wang,et al.  Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells , 2011, Nature Immunology.

[11]  J. Sprent,et al.  Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells , 2011, Nature Immunology.

[12]  D. Lauffenburger,et al.  Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8+ T cells , 2011, Immunology and cell biology.

[13]  Jung-Hyun Park,et al.  Seeing Is Believing: Illuminating the Source of In Vivo Interleukin-7 , 2011, Immune network.

[14]  C. Brander,et al.  Ets-1 Maintains IL-7 Receptor Expression in Peripheral T Cells , 2011, The Journal of Immunology.

[15]  Daniel R. Beisner,et al.  Foxo transcription factors control regulatory T cell development and function. , 2010, Immunity.

[16]  W. Leonard,et al.  Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling , 2010, Proceedings of the National Academy of Sciences.

[17]  H. Grimes,et al.  Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis , 2010, Proceedings of the National Academy of Sciences.

[18]  Nikhil S. Joshi,et al.  Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival , 2010, Proceedings of the National Academy of Sciences.

[19]  G. Willimsky,et al.  Commensal microflora and interferon‐γ promote steady‐state interleukin‐7 production in vivo , 2010, European journal of immunology.

[20]  F. Finkelman,et al.  STAT5 Is Critical To Maintain Effector CD8+ T Cell Responses , 2010, The Journal of Immunology.

[21]  F. Aoudjit,et al.  Interleukin‐7 promotes the survival of human CD4+ effector/memory T cells by up‐regulating Bcl‐2 proteins and activating the JAK/STAT signalling pathway , 2010, Immunology.

[22]  R. DePinho,et al.  Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells , 2010, Nature Immunology.

[23]  J. Sprent,et al.  Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells? , 2010, Nature Immunology.

[24]  C. Mackall,et al.  Reply to “Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells?” , 2010, Nature Immunology.

[25]  J. Rathmell,et al.  The metabolic life and times of a T‐cell , 2010, Immunological reviews.

[26]  J. Rathmell,et al.  IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo , 2010, The Journal of Immunology.

[27]  J. Sprent,et al.  T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis. , 2010, Immunity.

[28]  You-Wen He,et al.  Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2 , 2010, Cell Death and Differentiation.

[29]  W. Li,et al.  Interleukin-7 Regulates Bim Proapoptotic Activity in Peripheral T-Cell Survival , 2009, Molecular and Cellular Biology.

[30]  M. Ishii,et al.  Visualization and Identification of IL-7 Producing Cells in Reporter Mice , 2009, PloS one.

[31]  Caiying Guo,et al.  T cells require Foxo1 to populate the peripheral lymphoid organs , 2009, European journal of immunology.

[32]  S. Hedrick.  The cunning little vixen: Foxo and the cycle of life and death , 2009, Nature Immunology.

[33]  W. Leonard,et al.  New insights into the regulation of T cells by γc family cytokines , 2009, Nature Reviews Immunology.

[34]  C. Benoist,et al.  Foxp3+ regulatory T cells: differentiation, specification, subphenotypes , 2009, Nature Immunology.

[35]  M. Bedford,et al.  IL7‐hCD25 and IL7‐Cre BAC transgenic mouse lines: New tools for analysis of IL‐7 expressing cells , 2009, Genesis.

[36]  R. Flavell,et al.  An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. , 2009, Immunity.

[37]  D. Fruman,et al.  Fine tuning the immune response with PI3K , 2009, Immunological reviews.

[38]  A. Cumano,et al.  Characterization of the thymic IL-7 niche in vivo , 2009, Proceedings of the National Academy of Sciences.

[39]  Daniel R. Beisner,et al.  Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor , 2009, Nature Immunology.

[40]  L. Hennighausen,et al.  Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells , 2009, Nature Immunology.

[41]  J. Sprent,et al.  Homeostasis of naive and memory T cells. , 2008, Immunity.

[42]  S. Hedrick,et al.  The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival1 , 2008, The Journal of Immunology.

[43]  H. Hosokawa,et al.  Gfi1-mediated Stabilization of GATA3 Protein Is Required for Th2 Cell Differentiation* , 2008, Journal of Biological Chemistry.

[44]  W. Leonard,et al.  Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. , 2008, Blood.

[45]  V. Lazar,et al.  FOXO1 Regulates L-Selectin and a Network of Human T Cell Homing Molecules Downstream of Phosphatidylinositol 3-Kinase1 , 2008, The Journal of Immunology.

[46]  You-Wen He,et al.  The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages1 , 2008, The Journal of Immunology.

[47]  T. Malek,et al.  A Function for IL-7R for CD4+CD25+Foxp3+ T Regulatory Cells1 , 2008, The Journal of Immunology.

[48]  T. Lebien,et al.  IL-7 Activates the Phosphatidylinositol 3-Kinase/AKT Pathway in Normal Human Thymocytes but Not Normal Human B Cell Precursors1 , 2008, The Journal of Immunology.

[49]  J. Guardiola,et al.  Kinetics of In Vivo Proliferation and Death of Memory and Naive CD8 T Cells: Parameter Estimation Based on 5-Bromo-2′-Deoxyuridine Incorporation in Spleen, Lymph Nodes, and Bone Marrow 1 , 2008, The Journal of Immunology.

[50]  R. V. van Lier,et al.  Differential Regulation of Human IL-7 Receptor α Expression by IL-7 and TCR Signaling1 , 2008, The Journal of Immunology.

[51]  Nikhil S. Joshi,et al.  Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. , 2008, Journal of immunology.

[52]  J. Rathmell,et al.  IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. , 2008, Blood.

[53]  B. Schraven,et al.  Regulation of T Cell Homeostasis by the Transmembrane Adaptor Protein SIT1 , 2008, The Journal of Immunology.

[54]  B. Schraven,et al.  Regulation of T Cell Homeostasis by the Transmembrane Adaptor Protein SIT , 2008 .

[55]  A. Singer,et al.  'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR , 2007, Nature Immunology.

[56]  B. Hinz,et al.  Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells , 2007, Nature Immunology.

[57]  Roger L. Williams,et al.  The emerging shape of the ESCRT machinery , 2007, Nature Reviews Molecular Cell Biology.

[58]  Michael G. Kharas,et al.  T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. , 2007, Blood.

[59]  T. Malek,et al.  Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells1 , 2007, The Journal of Immunology.

[60]  M. Goldsmith,et al.  Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice , 2007, The Journal of experimental medicine.

[61]  R. Mazzucchelli,et al.  Interleukin-7 receptor expression: intelligent design , 2007, Nature Reviews Immunology.

[62]  N. Taylor,et al.  IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway. , 2007, Blood.

[63]  You-Wen He,et al.  A critical role for the autophagy gene Atg5 in T cell survival and proliferation , 2007, The Journal of experimental medicine.

[64]  M. Farrar,et al.  IL-7/STAT5 Cytokine Signaling Pathway Is Essential but Insufficient for Maintenance of Naive CD4 T Cell Survival in Peripheral Lymphoid Organs1 , 2007, The Journal of Immunology.

[65]  M. Farrar,et al.  IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 , 2007, The Journal of Immunology.

[66]  L. Lefrançois,et al.  Cutting Edge: IL-7-Independent Regulation of IL-7 Receptor α Expression and Memory CD8 T Cell Development1 , 2006, The Journal of Immunology.

[67]  A. Cumano,et al.  Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7. , 2006, Blood.

[68]  M. Tolaini,et al.  Do CD8 effector cells need IL-7R expression to become resting memory cells? , 2006, Blood.

[69]  L. Garrett-Sinha,et al.  Impaired Generation of CD8+ Thymocytes in Ets-1-Deficient Mice1 , 2006, The Journal of Immunology.

[70]  L. Hennighausen,et al.  Stat5a/b are essential for normal lymphoid development and differentiation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[71]  A. Rudensky,et al.  A function for interleukin 2 in Foxp3-expressing regulatory T cells , 2005, Nature Immunology.

[72]  U. Kölsch,et al.  The Transmembrane Adapter Protein SIT Regulates Thymic Development and Peripheral T-Cell Functions , 2005, Molecular and Cellular Biology.

[73]  G. Landreth,et al.  ERK1-Deficient Mice Show Normal T Cell Effector Function and Are Highly Susceptible to Experimental Autoimmune Encephalomyelitis1 , 2005, The Journal of Immunology.

[74]  Q. Jiang,et al.  Cell biology of IL-7, a key lymphotrophin. , 2005, Cytokine & growth factor reviews.

[75]  J. Sprent,et al.  Regulation of mature T cell homeostasis. , 2005, Seminars in immunology.

[76]  A. Troy,et al.  Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion1 , 2005, The Journal of Immunology.

[77]  J. Barata,et al.  Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells , 2004, The Journal of experimental medicine.

[78]  A. Singer,et al.  Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. , 2004, Immunity.

[79]  Q. Jiang,et al.  Interleukin-7 Inactivates the Pro-apoptotic Protein Bad Promoting T Cell Survival* , 2004, Journal of Biological Chemistry.

[80]  B. Foxwell,et al.  A Late, Prolonged Activation of the Phosphatidylinositol 3-Kinase Pathway Is Required for T Cell Proliferation1 , 2004, The Journal of Immunology.

[81]  C. Surh,et al.  A Role for TCR Affinity in Regulating Naive T Cell Homeostasis 1 , 2004, The Journal of Immunology.

[82]  W. Leonard,et al.  GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. , 2004, Nature Immunology.

[83]  S. Korsmeyer,et al.  Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 , 2003, Nature.

[84]  E. Wherry,et al.  Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells , 2003, Nature Immunology.

[85]  B. Stockinger,et al.  Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells , 2003, The Journal of experimental medicine.

[86]  T. Hoang,et al.  Growth Factor Independence-1B Expression Leads to Defects in T Cell Activation, IL-7 Receptor α Expression, and T Cell Lineage Commitment1 , 2003, The Journal of Immunology.

[87]  W. Paul,et al.  Neonates support lymphopenia-induced proliferation. , 2003, Immunity.

[88]  W. Leonard,et al.  IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[89]  K. Okkenhaug,et al.  Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice , 2002, Science.

[90]  J. Sprent,et al.  Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells , 2002, The Journal of experimental medicine.

[91]  C. Pénit,et al.  Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[92]  W. Leonard,et al.  IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes. , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[93]  C. Thompson,et al.  IL-7 Enhances the Survival and Maintains the Size of Naive T Cells1 , 2001, The Journal of Immunology.

[94]  Z. Dai,et al.  Cutting Edge: Secondary Lymphoid Organs Are Essential for Maintaining the CD4, But Not CD8, Naive T Cell Pool1 , 2001, The Journal of Immunology.

[95]  M. Purbhoo,et al.  Sensory Adaptation in Naive Peripheral CD4 T Cells , 2001, The Journal of experimental medicine.

[96]  Richard Murray,et al.  IL-7 is critical for homeostatic proliferation and survival of naïve T cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[97]  C. Surh,et al.  Autologous Regulation of Naive T Cell Homeostasis Within the T Cell Compartment1 , 2001, The Journal of Immunology.

[98]  S. Jameson,et al.  Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo , 2000, Nature Immunology.

[99]  Hiroshi Nakajima,et al.  Janus kinase 3 (Jak3) is essential for common cytokine receptor γ chain (γc)-dependent signaling: comparative analysis of γc, Jak3, and γc and Jak3 double-deficient mice , 2000 .

[100]  W. Leonard,et al.  Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice. , 2000, International immunology.

[101]  K. Muegge,et al.  Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[102]  J. Pouysségur,et al.  Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. , 1999, Science.

[103]  J. Sprent,et al.  The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. , 1999, Immunity.

[104]  I. Kerr,et al.  Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells , 1995, European journal of immunology.

[105]  S. Burdach,et al.  Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine , 1995, The Journal of experimental medicine.

[106]  E Morelon,et al.  Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains , 1995, The Journal of cell biology.

[107]  C. Ware,et al.  Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice , 1994, The Journal of experimental medicine.

[108]  A. Venkitaraman,et al.  Interleukin‐7 induces the association of phosphatidylinositol 3‐kinase with the α chain of the interleukin‐7 receptor , 1994, European journal of immunology.

[109]  J. Sprent,et al.  Turnover of Naive-and Memory-phenotype T Cells , 1994 .