Radiological Features of the Surgically Resected Small-sized Small-cell Lung Cancer on Computed Tomography.

BACKGROUND/AIM Surgical resection can be applied in cases of early-stage small-cell lung cancer (SCLC). Predicting the histology of SCLC and discriminating SCLC from other histologies would be useful for determining the optimal treatment strategies for small pulmonary nodules that have not been preoperatively diagnosed. MATERIALS AND METHODS The study population included 17 patients with resected SCLC and 296 patients with adenocarcinoma (ADC) whose preoperative CT were available. The tumors of all patients were smaller than 3.0 cm. RESULTS Univariate and multivariate analyses demonstrated that SCLC was significantly associated with the presence of notching and the absence of surrounding ground glass opacity, air bronchogram, pleural indentation, and spiculation in comparison to ADC. CONCLUSION The CT scans of patients with SCLC of less than 3.0 cm in size showed notching more frequently than those of patients with ADC, whereas surrounding GGO, air bronchogram, pleural indentation and spiculation were observed less frequently compared to ADC.

[1]  D. Boffa,et al.  Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base , 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[2]  C. Rudin,et al.  Small cell lung cancer: Where do we go from here? , 2015, Cancer.

[3]  C. Rudin,et al.  Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. , 2015, The New England journal of medicine.

[4]  L. Crinò,et al.  Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. , 2015, The New England journal of medicine.

[5]  Y. Ichinose,et al.  Role of surgical resection for patients with limited disease-small cell lung cancer. , 2015, Lung cancer.

[6]  Kenji Suzuki,et al.  A Prospective Radiological Study of Thin-Section Computed Tomography to Predict Pathological Noninvasiveness in Peripheral Clinical IA Lung Cancer (Japan Clinical Oncology Group 0201) , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[7]  K Kuriyama,et al.  Ground-glass opacity on thin-section CT: value in differentiating subtypes of adenocarcinoma of the lung. , 1999, AJR. American journal of roentgenology.

[8]  J P Pignon,et al.  A meta-analysis of thoracic radiotherapy for small-cell lung cancer. , 1992, The New England journal of medicine.

[9]  S S Sagel,et al.  CT of the pulmonary nodule: a cooperative study. , 1986, Radiology.

[10]  Jun Wang,et al.  Development and validation of a clinical prediction model to estimate the probability of malignancy in solitary pulmonary nodules in Chinese people. , 2011, Clinical lung cancer.

[11]  R. Landreneau,et al.  Surgical resection should be considered for stage I and II small cell carcinoma of the lung. , 2012, The Annals of thoracic surgery.

[12]  P. Warde,et al.  Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[13]  R. G. Lacsamana,et al.  Where do we go from here? , 1986, The Journal of the Florida Medical Association.

[14]  S. Lam,et al.  Probability of cancer in pulmonary nodules detected on first screening CT. , 2013, The New England journal of medicine.

[15]  Y. Maehara,et al.  Surgical results of resectable small cell lung cancer , 2015, Thoracic cancer.