Chemical biology of antigen presentation by MHC molecules.

[1]  G. Røder,et al.  Tapasin Facilitation of Natural HLA-A and -B Allomorphs Is Strongly Influenced by Peptide Length, Depends on Stability, and Separates Closely Related Allomorphs , 2013, The Journal of Immunology.

[2]  S. Danishefsky,et al.  A vision for vaccines built from fully synthetic tumor-associated antigens: from the laboratory to the clinic. , 2013, Journal of the American Chemical Society.

[3]  F. Förster,et al.  Unveiling the long-held secrets of the 26S proteasome. , 2013, Structure.

[4]  D. Vourloumis,et al.  Novel selective inhibitors of aminopeptidases that generate antigenic peptides. , 2013, Bioorganic & medicinal chemistry letters.

[5]  P. Lehner,et al.  MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation , 2013, Proceedings of the National Academy of Sciences.

[6]  H. Brandstetter,et al.  Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation , 2013, Proceedings of the National Academy of Sciences.

[7]  T. Elliott,et al.  Induction of Protective Antitumor Immunity through Attenuation of ERAAP Function , 2013, The Journal of Immunology.

[8]  S. Agrawal,et al.  T cell responses to citrullinated self-peptides in patients with rheumatoid arthritis , 2013, Rheumatology International.

[9]  P. Roche,et al.  Major Histocompatibility Complex (MHC) Class II-Peptide Complexes Arrive at the Plasma Membrane in Cholesterol-rich Microclusters* , 2013, The Journal of Biological Chemistry.

[10]  A. Goldberg,et al.  Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins , 2013, Cell.

[11]  J. Trowsdale,et al.  Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway , 2013, Proceedings of the National Academy of Sciences.

[12]  Daniel R. Beisner,et al.  The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain , 2013, The Journal of experimental medicine.

[13]  R. Lüllmann-Rauch,et al.  The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain , 2013, The Journal of experimental medicine.

[14]  T. Andrews,et al.  B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8− dendritic cells require the intramembrane endopeptidase SPPL2A , 2013, The Journal of experimental medicine.

[15]  P. Cresswell,et al.  MHC Class II-Restricted Presentation of the Major House Dust Mite Allergen Der p 1 Is GILT-Dependent: Implications for Allergic Asthma , 2013, PloS one.

[16]  P. Jensen,et al.  Immunodeficiency and Autoimmunity in H2-O–Deficient Mice , 2013, The Journal of Immunology.

[17]  H. Phipps-Yonas,et al.  GILT expression in B cells diminishes cathepsin S steady‐state protein expression and activity , 2013, European journal of immunology.

[18]  T. Schumacher,et al.  Development of a Hypersensitive Periodate-Cleavable Amino Acid that is Methionine- and Disulfide-Compatible and its Application in MHC Exchange Reagents for T Cell Characterisation , 2012, Chembiochem : a European journal of chemical biology.

[19]  K. Wucherpfennig,et al.  Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection , 2012, Cell.

[20]  T. Burster.  Processing and regulation mechanisms within antigen presenting cells: a possibility for therapeutic modulation. , 2012, Current pharmaceutical design.

[21]  Wei Jiang,et al.  HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism , 2012, Nature Structural &Molecular Biology.

[22]  K. Rock,et al.  Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides , 2012, Proceedings of the National Academy of Sciences.

[23]  E. Unanue,et al.  Unconventional recognition of peptides by T cells and the implications for autoimmunity , 2012, Nature Reviews Immunology.

[24]  J. Yewdell,et al.  Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters , 2012, Proceedings of the National Academy of Sciences.

[25]  P. Cresswell,et al.  Dynamics of Major Histocompatibility Complex Class I Association with the Human Peptide-loading Complex , 2012, The Journal of Biological Chemistry.

[26]  J. Yewdell,et al.  All roads lead to "ome": defining the DRiPome. , 2012, Blood.

[27]  M. Ressing,et al.  Viral interference with antigen presentation: trapping TAP. , 2012, Molecular immunology.

[28]  Ton N Schumacher,et al.  Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers , 2012, Nature Protocols.

[29]  Ricarda Schwab,et al.  Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity , 2012, Cell.

[30]  B. J. Van den Eynde,et al.  Proteasome subtypes and the processing of tumor antigens: increasing antigenic diversity. , 2012, Current opinion in immunology.

[31]  K. Rock,et al.  Mice completely lacking immunoproteasomes display major alterations in antigen presentation , 2011, Nature Immunology.

[32]  J. Neefjes,et al.  Towards a systems understanding of MHC class I and MHC class II antigen presentation , 2011, Nature Reviews Immunology.

[33]  H. Ovaa,et al.  A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function , 2011, ACS chemical biology.

[34]  Paul Weston,et al.  Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility , 2011, Nature Genetics.

[35]  Annette M. McGehee,et al.  Ubiquitin-Dependent Control of Class II MHC Localization Is Dispensable for Antigen Presentation and Antibody Production , 2011, PloS one.

[36]  Grazyna Kochan,et al.  Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming , 2011, Proceedings of the National Academy of Sciences.

[37]  G. Salvesen,et al.  Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. , 2011, The Biochemical journal.

[38]  P. Cresswell,et al.  A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation , 2011, Cell.

[39]  O. Bakke,et al.  Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells , 2010, Proceedings of the National Academy of Sciences.

[40]  P. Cresswell,et al.  GILT Accelerates Autoimmunity to the Melanoma Antigen Tyrosinase-Related Protein 1 , 2010, The Journal of Immunology.

[41]  P. Kloetzel,et al.  Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress , 2010, Cell.

[42]  Robert Tampé,et al.  ABC proteins in antigen translocation and viral inhibition. , 2010, Nature chemical biology.

[43]  M. Percival,et al.  Pharmacological Inhibition of Cathepsin S Decreases Atherosclerotic Lesions in Apoe-/- Mice , 2010, Journal of cardiovascular pharmacology.

[44]  P. Cresswell,et al.  Defective Cross-Presentation of Viral Antigens in GILT-Free Mice , 2010, Science.

[45]  K. Wucherpfennig,et al.  Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. , 2010, The Journal of clinical investigation.

[46]  Keiji Tanaka,et al.  Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. , 2010, Immunity.

[47]  S. H. van der Burg,et al.  Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. , 2009, The New England journal of medicine.

[48]  M. Kawahara,et al.  Analysis of the Role of Tripeptidyl Peptidase II in MHC Class I Antigen Presentation In Vivo1 , 2009, The Journal of Immunology.

[49]  T. Schumacher,et al.  Generation of Peptide MHC Class I Monomers and Multimers Through Ligand Exchange , 2009, Current protocols in immunology.

[50]  T. Schumacher,et al.  Class I major histocompatibility complexes loaded by a periodate trigger. , 2009, Journal of the American Chemical Society.

[51]  P. Lehner,et al.  The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases. , 2009, Experimental cell research.

[52]  S. H. van der Burg,et al.  Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells. , 2009, Molecular immunology.

[53]  Karin M Reinisch,et al.  Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. , 2009, Immunity.

[54]  Hidde L. Ploegh,et al.  Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers , 2008, Proceedings of the National Academy of Sciences.

[55]  Pritam Das,et al.  A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers , 2007 .

[56]  S. H. van der Burg,et al.  Distinct Uptake Mechanisms but Similar Intracellular Processing of Two Different Toll-like Receptor Ligand-Peptide Conjugates in Dendritic Cells* , 2007, Journal of Biological Chemistry.

[57]  O. Ohara,et al.  Novel regulation of MHC class II function in B cells , 2007, The EMBO journal.

[58]  C. Melief,et al.  Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination. , 2006, Immunity.

[59]  I. Mellman,et al.  Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination , 2006, Nature.

[60]  T. Schumacher,et al.  Generation of peptide–MHC class I complexes through UV-mediated ligand exchange , 2006, Nature Protocols.

[61]  Jeffrey K. Mito,et al.  An Antigen Produced by Splicing of Noncontiguous Peptides in the Reverse Order , 2006, Science.

[62]  A. Goldberg,et al.  Tripeptidyl Peptidase II Is the Major Peptidase Needed to Trim Long Antigenic Precursors, but Is Not Required for Most MHC Class I Antigen Presentation1 , 2006, The Journal of Immunology.

[63]  K. Camphausen,et al.  Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy , 2006, The Journal of experimental medicine.

[64]  H. Ploegh,et al.  Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. , 2006, Structure.

[65]  T. Schumacher,et al.  Design and use of conditional MHC class I ligands , 2006, Nature Medicine.

[66]  H. Chapman,et al.  Endosomal proteases in antigen presentation. , 2006, Current opinion in immunology.

[67]  J. Villadangos,et al.  Destructive potential of the aspartyl protease cathepsin D in MHC class II‐restricted antigen processing , 2005, European journal of immunology.

[68]  A. Goldberg,et al.  The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[69]  O. Johnell,et al.  The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans , 2005, European journal of immunology.

[70]  W. Zwart,et al.  Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape. , 2005, Immunity.

[71]  T. Golde,et al.  A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin* , 2004, Journal of Biological Chemistry.

[72]  T. Boon,et al.  An Antigenic Peptide Produced by Peptide Splicing in the Proteasome , 2004, Science.

[73]  Jonathan W. Yewdell,et al.  Immune recognition of a human renal cancer antigen through post-translational protein splicing , 2004, Nature.

[74]  P. Benaroch,et al.  Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone. , 2003, Immunity.

[75]  A. Goldberg,et al.  The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. , 2003, Immunity.

[76]  Concepción Marañón,et al.  An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope , 2003, Nature Immunology.

[77]  N. Ishimaru,et al.  Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity. , 2002, The Journal of clinical investigation.

[78]  N. Viner,et al.  Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP , 2002, Nature Immunology.

[79]  A. Rudensky,et al.  Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells , 2001, The Journal of cell biology.

[80]  A. Rudensky,et al.  Cathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes* , 2001, The Journal of Biological Chemistry.

[81]  A. Goldberg,et al.  26S proteasomes and immunoproteasomes produce mainly N‐extended versions of an antigenic peptide , 2001, The EMBO journal.

[82]  J. Neefjes,et al.  Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel. , 2000, Immunity.

[83]  A. Goldberg,et al.  Proteolysis and class I major histocompatibility complex antigen presentation , 1999, Immunological reviews.

[84]  J. Neefjes,et al.  Recycling MHC class I molecules and endosomal peptide loading. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[85]  J. Neefjes,et al.  Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling , 1997 .

[86]  R. Steinman,et al.  Developmental regulation of MHC class II transport in mouse dendritic cells , 1997, Nature.

[87]  J. Neefjes,et al.  The rational design of TAP inhibitors using peptide substrate modifications and peptidomimetics , 1997, European journal of immunology.

[88]  J. Neefjes,et al.  Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface , 1996, The Journal of cell biology.

[89]  C. Melief,et al.  Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing. , 1996, Journal of immunology.

[90]  H. Ploegh,et al.  Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. , 1996, Immunity.

[91]  W. Lipscomb,et al.  X-ray crystallographic determination of the structure of bovine lens leucine aminopeptidase complexed with amastatin: formulation of a catalytic mechanism featuring a gem-diolate transition state. , 1993, Biochemistry.

[92]  W. Lipscomb,et al.  Differentiation and identification of the two catalytic metal binding sites in bovine lens leucine aminopeptidase by x-ray crystallography. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[93]  G. Loss,et al.  Invariant chain retains MHC class II molecules in the endocytic pathway. , 1993, Journal of immunology.

[94]  H. Mizuno,et al.  Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites. , 1992, The Biochemical journal.

[95]  J. Neefjes,et al.  Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes. , 1992, The EMBO journal.

[96]  P. Hiestand,et al.  Overcoming multidrug resistance in Chinese hamster ovary cells in vitro by cyclosporin A (Sandimmune) and non-immunosuppressive derivatives. , 1989, British Journal of Cancer.

[97]  K. Hotta,et al.  Purification and characterization of an alpha-glucosidase specific for hydroxylysine-linked disaccharide of collagen. , 1979, The Journal of biological chemistry.

[98]  R. Böckmann,et al.  HLA-B27 and antigen presentation: at the crossroads between immune defense and autoimmunity. , 2014, Molecular immunology.

[99]  D. Filippov,et al.  TLR ligand-peptide conjugate vaccines: toward clinical application. , 2012, Advances in immunology.

[100]  Kochan Grazyna,et al.  小胞体アミノペプチダーゼ‐1(ERAP1)の結晶構造は,N末端ペプチドトリミングの分子基盤を明らかにする , 2011 .

[101]  P. Kloetzel,et al.  Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes , 2011, Nature Immunology.

[102]  N. Shastri,et al.  The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules , 2006, Nature Immunology.

[103]  R. Ménard,et al.  Family C1 Cysteine Proteases: Biological Diversity or Redundancy? , 2003, Biological chemistry.

[104]  Kees Jalink,et al.  Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. , 2003, Immunity.