Wide field OCT angiography by using swept source OCT in living human eye

To investigate the application of wide field OCT angiography (OCTA) in living human eye. Normal and pathologic eyes were recruited and imaged by a 1060 nm swept source OCTA system with A-line speed of 100 kHz provided by Carl Zeiss Meditec. Inc.. Wide field OCTA images were generated in a single scan within 5 seconds based on the tracking capability installed in the system with 9 x 9 mm2 and 12 x 12 mm2 field of view and sampled by 500 A-lines x 500 Bframes with 2 repetitions in the same location for one 3D data. Complex optical microangiography (OMAG) algorithm was used to extract the blood flow information. The en face maximum projection provided by the device was used to generate 2-dimensional angiograms of different layers and color-code images. Wide field en face OCTA images of different macular diseases showed a great agreement with fluorescein angiography (FA). Meanwhile, OCTA provides depth-resolved information and detailed vascular images of venous occlusion and DR patients in far peripheral region, and choroidal vessels imaging in serpiginous choroidopathy patient, providing a better visualization of vascular network compared to FA.

[1]  Ruikang K. Wang,et al.  Methods and algorithms for optical coherence tomography-based angiography: a review and comparison , 2015, Journal of biomedical optics.

[2]  Ruikang K. Wang,et al.  Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications , 2016, Biomedical optics express.

[3]  Ruikang K. Wang,et al.  Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source. , 2016, Biomedical optics express.

[4]  Ruikang K. Wang,et al.  Swept-source OCT angiography of macular telangiectasia type 2. , 2014, Ophthalmic surgery, lasers & imaging retina.

[5]  Chen Xin,et al.  Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography , 2016, Journal of biomedical optics.

[6]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[7]  Ruikang K. Wang,et al.  Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds. , 2010, Optics express.

[8]  Ruikang K. Wang,et al.  Three dimensional optical angiography. , 2007, Optics express.

[9]  Ruikang K. Wang,et al.  Original articleOptical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration , 2016 .

[10]  Ruikang K. Wang,et al.  Wide-field optical coherence tomography based microangiography for retinal imaging , 2016, Scientific Reports.

[11]  Ruikang K. Wang,et al.  Wide-field optical coherence tomography angiography enabled by two repeated measurements of B-scans. , 2016, Optics letters.

[12]  Ruikang K. Wang,et al.  Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography. , 2010, Optics letters.

[13]  Ruikang K. Wang,et al.  Swept-source OCT Angiography of the Retinal Vasculature using Intensity Differentiation Based OMAG Algorithms , 2015 .

[14]  Ruikang K. Wang,et al.  Optical Microangiography: A Label-Free 3-D Imaging Technology to Visualize and Quantify Blood Circulations Within Tissue Beds In Vivo , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[15]  Ruikang K. Wang,et al.  User-guided segmentation for volumetric retinal optical coherence tomography images. , 2014, Journal of biomedical optics.

[16]  Ruikang K. Wang,et al.  Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography. , 2015, Biomedical optics express.