Neural tube defects in Western Australia 1966-81 and a review of Australian data 1942-81.

Cases of neural tube defects born in Western Australia during the years 1966-81 were identified from hospital records and death certificates. The overall rate for the 16 year period was 1.81 cases of neural tube defects per 1000 births. The rate rose and then fell over the 16 years. The initial lower rate may have been due to underascertainment, but the recent dramatic fall is statistically significant and has been observed in other Australian states and other parts of the world. This fall was not accounted for by termination of affected pregnancies before 20 weeks' gestation nor by demographic changes in birth order, father's occupation, or parental country of birth. The birth prevalence of neural tube defects determined in previous Australian studies is reviewed in relation to the recent decline in these disorders.

[1]  C. Mathers,et al.  Some international trends in the incidence of neural tube defects. , 2010, Community health studies.

[2]  A. Stoller,et al.  The occurrence of anencephalus in the State of Victoria, Australia. , 2008, Journal of mental deficiency research.

[3]  J. Romijn,et al.  ANENCEPHALY IN THE NETHERLANDS: A REMARKABLE DECLINE , 1983, The Lancet.

[4]  D. Danks,et al.  INCIDENCE OF NEURAL TUBE DEFECTS IN VICTORIA, AUSTRALIA , 1983, The Lancet.

[5]  L. Edmonds,et al.  Current trends in the incidence of neural tube defects. , 1982, Pediatrics.

[6]  F. Harris,et al.  19-YEAR INCIDENCE OF NEURAL TUBE DEFECTS IN AREA UNDER CONSTANT SURVEILLANCE , 1981, The Lancet.

[7]  J. Elwood,et al.  POSSIBLE PREVENTION OF NEURAL-TUBE DEFECTS BY PERICONCEPTIONAL VITAMIN SUPPLEMENTATION , 1980, The Lancet.

[8]  A. Read,et al.  POSSIBLE PREVENTION OF NEURAL-TUBE DEFECTS BY PERICONCEPTIONAL VITAMIN SUPPLEMENTATION , 1980, The Lancet.

[9]  B. Field.  Neural tube defects in New South Wales, Australia , 1978, Journal of medical genetics.

[10]  J. Drew,et al.  INCIDENCES AND TYPES OF MALFORMATIONS IN NEWBORN INFANTS , 1977 .

[11]  O. Miettinen,et al.  Estimability and estimation in case-referent studies. , 1976, American journal of epidemiology.

[12]  J. Renwick.  Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers. , 1972, British journal of preventive & social medicine.

[13]  S. Beal.  THE OCCURRENCE OF SPINA BIFIDA CYSTICA IN SOUTH AUSTRALIA , 1967, The Medical journal of Australia.

[14]  W. Jones.  ANENCEPHALUS: A 23‐YEAR SURVEY IN A SYDNEY HOSPITAL , 1967, The Medical journal of Australia.

[15]  A. Stoller,et al.  PATTERNS OF OCCURRENCE OF BIRTHS IN VICTORIA, AUSTRALIA, PRODUCING DOWN'S SYNDROME (MONGOLISM) AND CONGENITAL ANOMALIES OF THE CENTRAL NERVOUS SYSTEM: A 21‐YEAR PROSPECTIVE AND RETROSPECTIVE SURVEY , 1965, The Medical journal of Australia.

[16]  F. Betheras.  Obstetrical Aspects of Foetal Hydrocephalus and Anencephalus , 1962 .

[17]  A. Stevenson,et al.  Congenital malformations. A report of a study of series of consecutive births in 24 centres. , 1966, Bulletin of the World Health Organization.

[18]  Stevenson Ac,et al.  Congenital malformations : a report of a study of series of consecutive births in 24 centres , 1966 .