Regulation of transcription factor function by phosphorylation

[1]  Alexander Varshavsky,et al.  The ubiquitin system. , 1998, Annual review of biochemistry.

[2]  C. Scheidereit,et al.  NF‐κB p105 is a target of IκB kinases and controls signal induction of Bcl‐3–p50 complexes , 1999 .

[3]  M. J. Barratt,et al.  The nucleosomal response associated with immediate‐early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG‐14 kinase , 1999, The EMBO journal.

[4]  C. Allis,et al.  Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. , 1999, Science.

[5]  J. Egly,et al.  Kinase Activity and Phosphorylation of the Largest Subunit of TFIIF Transcription Factor* , 1999, The Journal of Biological Chemistry.

[6]  J. Darnell,et al.  Stat3 as an Oncogene , 1999, Cell.

[7]  T. Kouzarides,et al.  Residues phosphorylated by TFIIH are required for E2F‐1 degradation during S‐phase , 1999, The EMBO journal.

[8]  M. Yaffe,et al.  Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. , 1999, Molecular cell.

[9]  R. Nusse,et al.  Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. , 1999, Genes & development.

[10]  P. Sassone-Corsi,et al.  Signaling routes to CREM and CREB: plasticity in transcriptional activation. , 1999, Trends in biochemical sciences.

[11]  E. Zandi,et al.  Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex , 1999, Molecular and Cellular Biology.

[12]  T. Hunter,et al.  Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[13]  D. Sgouras,et al.  Transcriptional Repressor ERF Is a Ras/Mitogen-Activated Protein Kinase Target That Regulates Cellular Proliferation , 1999, Molecular and Cellular Biology.

[14]  Andrew D. Sharrocks,et al.  Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors , 1999, Molecular and Cellular Biology.

[15]  Bruce A. Yankner,et al.  β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation , 1999 .

[16]  Jonathan A. Cooper,et al.  Protein modification: Docking sites for kinases , 1999, Current Biology.

[17]  A. Kumagai,et al.  Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25. , 1999, Genes & development.

[18]  D. Latchman,et al.  CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment. , 1999, Neuroreport.

[19]  K. Miyazono,et al.  Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. , 1999, Science.

[20]  S. Kornbluth,et al.  Maintenance of G2 arrest in the Xenopus oocyte: a role for 14‐3‐3‐mediated inhibition of Cdc25 nuclear import , 1999, The EMBO journal.

[21]  C. Allis,et al.  Phosphorylation of Histone H3 Is Required for Proper Chromosome Condensation and Segregation , 1999, Cell.

[22]  P. Silver,et al.  In or out? Regulating nuclear transport. , 1999, Current opinion in cell biology.

[23]  R. Grosschedl,et al.  Regulation of LEF-1/TCF transcription factors by Wnt and other signals. , 1999, Current opinion in cell biology.

[24]  J. Massagué,et al.  A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. , 1999, Genes & development.

[25]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[26]  F. McKeon,et al.  NF-AT activation requires suppression of Crm1-dependent export by calcineurin , 1999, Nature.

[27]  G. Crabtree.  Generic Signals and Specific Outcomes Signaling through Ca2+, Calcineurin, and NF-AT , 1999, Cell.

[28]  T. Maniatis,et al.  A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. , 1999, Genes & development.

[29]  T. Mustelin,et al.  Jun Kinase Phosphorylates and Regulates the DNA Binding Activity of an Octamer Binding Protein, T-Cell Factor β1 , 1999, Molecular and Cellular Biology.

[30]  Zhijian J. Chen,et al.  Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP , 1999 .

[31]  T. Kouzarides.  Histone acetylases and deacetylases in cell proliferation. , 1999, Current opinion in genetics & development.

[32]  L. Johnston,et al.  TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105 , 1999, Nature.

[33]  K Kornfeld,et al.  Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. , 1999, Genes & development.

[34]  P. Russell,et al.  Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein , 1999, Nature.

[35]  R. Honda,et al.  Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 , 1999, The EMBO journal.

[36]  M. Mann,et al.  Identification of the receptor component of the IκBα–ubiquitin ligase , 1998, Nature.

[37]  J. Girault,et al.  Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A , 1998, Nature.

[38]  C. Prives.  Signaling to p53 Breaking the MDM2–p53 Circuit , 1998, Cell.

[39]  K. Sakaguchi,et al.  DNA damage activates p53 through a phosphorylation-acetylation cascade. , 1998, Genes & development.

[40]  L. Bardwell,et al.  Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. , 1998, Genes & development.

[41]  M. Kirschner,et al.  Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. , 1998, Genes & development.

[42]  Y Taya,et al.  Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. , 1998, Science.

[43]  H. Bading,et al.  CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. , 1998, Science.

[44]  M. Pincus,et al.  MEKK1/JNK signaling stabilizes and activates p53. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[45]  M. Goebl,et al.  Phosphorylation of Nuclear MyoD Is Required for Its Rapid Degradation , 1998, Molecular and Cellular Biology.

[46]  M. Yaffe,et al.  Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. , 1998, Molecular cell.

[47]  V. Adler,et al.  JNK targets p53 ubiquitination and degradation in nonstressed cells. , 1998, Genes & development.

[48]  B. Wasylyk,et al.  Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. , 1998, Trends in biochemical sciences.

[49]  E. Stavridi,et al.  ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins , 1998, Nature Genetics.

[50]  E. Goldsmith,et al.  Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation , 1998, Cell.

[51]  K. Weis,et al.  Importins and exportins: how to get in and out of the nucleus. , 1998, Trends in biochemical sciences.

[52]  R. Tjian,et al.  Functional analysis of the human TAFII250 N-terminal kinase domain. , 1998, Molecular cell.

[53]  H. Okamura,et al.  Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. , 1998, Molecular cell.

[54]  A. Sharrocks,et al.  Differential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1 , 1998, The EMBO journal.

[55]  Akira Kikuchi,et al.  Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin , 1998 .

[56]  S. Berger,et al.  Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex , 1998, Molecular and Cellular Biology.

[57]  D. Meek,et al.  Multisite phosphorylation and the integration of stress signals at p53. , 1998, Cellular signalling.

[58]  K. Struhl.  Histone acetylation and transcriptional regulatory mechanisms. , 1998, Genes & development.

[59]  R. Treisman,et al.  Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation , 1998, Cell.

[60]  Tony Kouzarides,et al.  Retinoblastoma protein recruits histone deacetylase to repress transcription , 1998, Nature.

[61]  L. Magnaghi-Jaulin,et al.  Retinoblastoma protein represses transcription by recruiting a histone deacetylase , 1998, Nature.

[62]  J. Massagué,et al.  SMADs: mediators and regulators of TGF-β signaling , 1998 .

[63]  K. Helin,et al.  Regulation of cell proliferation by the E2F transcription factors. , 1998, Current opinion in genetics & development.

[64]  S. Mittnacht,et al.  Control of pRB phosphorylation. , 1998, Current opinion in genetics & development.

[65]  The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif , 1998, Molecular and Cellular Biology.

[66]  M J May,et al.  NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. , 1998, Annual review of immunology.

[67]  Y Taya,et al.  Enhanced phosphorylation of p53 by ATM in response to DNA damage. , 1998, Science.

[68]  J. Workman,et al.  Alteration of nucleosome structure as a mechanism of transcriptional regulation. , 1998, Annual review of biochemistry.

[69]  M. Pincus,et al.  MEKK 1 / JNK signaling stabilizes and activates p 53 , 1998 .

[70]  Hirofumi Tanaka,et al.  Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 , 1997, FEBS letters.

[71]  V. Fried,et al.  c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors* , 1997, The Journal of Biological Chemistry.

[72]  R. Nusse,et al.  Wnt signaling: a common theme in animal development. , 1997, Genes & development.

[73]  M Dickens,et al.  Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. , 1997, Science.

[74]  Gerald R. Fink,et al.  MAP Kinases with Distinct Inhibitory Functions Impart Signaling Specificity during Yeast Differentiation , 1997, Cell.

[75]  L. Bardwell,et al.  Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous- growth signalling pathway , 1997, Nature.

[76]  T. Hunter,et al.  Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain , 1997, Oncogene.

[77]  J. Darnell.  STATs and gene regulation. , 1997, Science.

[78]  I. Dusanter-Fourt,et al.  The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). , 1997, European journal of biochemistry.

[79]  E. Hafen,et al.  Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. , 1997, Genes & development.

[80]  N. Shiama.  The p300/CBP family: integrating signals with transcription factors and chromatin. , 1997, Trends in cell biology.

[81]  M. Strauss,et al.  The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. , 1997, European journal of biochemistry.

[82]  E. Nishida,et al.  Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase , 1997, The EMBO journal.

[83]  Christoph W. Turck,et al.  Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3 , 1997, Science.

[84]  Hans Clevers,et al.  Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC , 1997, Science.

[85]  Dirk Bohmann,et al.  Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases , 1997, Science.

[86]  P. Hogan,et al.  Transcription factors of the NFAT family: regulation and function. , 1997, Annual review of immunology.

[87]  Masahiko Hibi,et al.  c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions , 1996, Cell.

[88]  T Lagrange,et al.  The general transcription factors of RNA polymerase II. , 1996, Genes & development.

[89]  J. Svejstrup,et al.  The multiple roles of transcription/repair factor TFIIH. , 1996, Trends in biochemical sciences.

[90]  Ralf Janknecht,et al.  Transcriptional control: Versatile molecular glue , 1996, Current Biology.

[91]  H. Pahl,et al.  Control of gene expression by proteolysis. , 1996, Current opinion in cell biology.

[92]  H. K. Sluss,et al.  Selective interaction of JNK protein kinase isoforms with transcription factors. , 1996, The EMBO journal.

[93]  Marek Mlodzik,et al.  JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye , 1995, Cell.

[94]  Gerald M Rubin,et al.  Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway , 1995, Cell.

[95]  D. Bohmann,et al.  Intramolecular signal transduction in c‐Jun. , 1995, The EMBO journal.

[96]  N. Jones,et al.  ATF‐2 contains a phosphorylation‐dependent transcriptional activation domain. , 1995, The EMBO journal.

[97]  Richard Treisman,et al.  Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity , 1995, Cell.

[98]  M. Simon.  Signal transduction during the development of the Drosophila R7 photoreceptor. , 1994, Developmental biology.

[99]  H. Enslen,et al.  Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. , 1994, Genes & development.

[100]  Ernst Hafen,et al.  The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway , 1994, Nature.

[101]  M. Karin,et al.  JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain , 1994, Cell.

[102]  R. Davis,et al.  The mitogen-activated protein kinase signal transduction pathway. , 1993, The Journal of biological chemistry.

[103]  Tony Hunter,et al.  The regulation of transcription by phosphorylation , 1992, Cell.

[104]  Anthony C. Willis,et al.  Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors , 1991, Cell.