Technologic and Biologic Considerations in Neuro-Urologic Prostheses Development

Loss of volitional control of lower urinary tract function follows degenerative neurologic diseases and traumatic spinal cord injury. The development of implantable prosthetic devices for restoring function has evolved over the last ten years from the use of electrical detrusor stimulation to include urethral occlusion and volume sensing capabilities. Further efforts aimed at stimulating normal reflex function are dependent upon a thorough understanding of the biologic constraints and technologic limitations to this engineering design problem. An electromechanical system that circumvents these restrictions is described.

[1]  W. Bradley,et al.  Measurement of spread of excitation in the urinary detrusor muscle during reflex induction. , 1969, The Journal of urology.

[2]  J. Lapides.  Surgical therapy for abnormalities of the urinary sphincter in the female. , 1965, British journal of urology.

[3]  Fletcher Tf,et al.  Comparative morphologic features of urinary bladder innervation. , 1969 .

[4]  F. Flack,et al.  URINARY INCONTINENCE FOLLOWING SPINAL INJURY TREATED BY ELECTRONIC IMPLANT. , 1965, Lancet.

[5]  Timm Gw,et al.  Electrostimulation of the urinary detrusor to effect contraction and evacuation. , 1969 .

[6]  G. Timm,et al.  Intermittent occlusion system. , 1970, IEEE transactions on bio-medical engineering.

[7]  G W Timm,et al.  Bladder volume sensing by local distension measurement. , 1972, IEEE transactions on bio-medical engineering.

[8]  M. Søborg,et al.  A leucocyte migration technique for in vitro detection of cellular (delayed type) hypersensitivity in man. , 1969, Danish medical bulletin.

[9]  J. Wade,et al.  Experience with the Berry prosthesis. , 1969, The Journal of urology.

[10]  G W Timm,et al.  Bladder motility detection using the Hall effect. , 1973, IEEE transactions on bio-medical engineering.

[11]  A. Raney.  Re-evaluation of post-prostatectomy urinary incontinence with the Berry procedure. , 1969, The Journal of urology.

[12]  G W Timm,et al.  Electromechanical restoration of the micturition reflex. , 1971, IEEE transactions on bio-medical engineering.

[13]  G W Timm,et al.  Bladder volume sensing by resistance measurement. , 1971, IEEE transactions on bio-medical engineering.

[14]  T. Fletcher,et al.  Spinal cord representation of the micturition reflex , 1969, The Journal of comparative neurology.

[15]  G. Timm.  An implantable incontinence device. , 1971, Journal of biomechanics.

[16]  A. Kantrowitz,et al.  Urethral resistance during electrical stimulation. , 1966, Investigative urology.

[17]  W. Bradley,et al.  Quantitation of collagen in the wall of the human urinary bladder. , 1967, Journal of applied physiology.

[18]  J. Berry.  A New Procedure For Correction of Urinary Incontinence: Preliminary Report , 1961 .

[19]  S. Chou,et al.  Use of a radio transmitter receiver unit for the treatment of neurogenic bladder. A preliminary report. , 1962, Journal of neurosurgery.