An Intelligent Digital Microfluidic Processor for Biomedical Detection

An intelligent digital microfluidic processor for biomedical detection is presented. This potential architecture solves lots of traditional development bottlenecks to implement the easy-to-control, easy-to-monitor, system automation and high accuracy for bioassay detection purposes. The proposed processor integrates the functions of microfluidic actuation, droplet location readback and high sensitivity measurement window to demonstrate a novel prototype for personalized medicine. Furthermore, the droplet location map and reaction behaviors are visible on a 2-dimentional (2D) graphical user-interface due to the micro electrode dot array (MEDA) architecture and capacitive sensing technology, and hence system automation is achievable. Fabricated in standard 0.35 μm CMOS process, this work integrates 900 microelectrodes with measurement window in 3.2 mm2, where the high sensitivity capacitive readout circuit occupies only 0.048 mm2. Measurement results show that microdroplet actuation and 2D location map are activated under 1KHz. In addition, the function of digital signal extraction, processing, as well as statistical analysis can be operated under 1 MHz respectively.

[1]  P. Bruschi,et al.  A low-power capacitance to pulse width converter for MEMS interfacing , 2008, ESSCIRC 2008 - 34th European Solid-State Circuits Conference.

[2]  R. Fair,et al.  An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids. , 2004, Lab on a chip.

[3]  Roland Zengerle,et al.  Microfluidic platforms for lab-on-a-chip applications. , 2007, Lab on a chip.

[4]  Chen-Yi Lee,et al.  A digital microfluidic processor for biomedical applications , 2013, SiPS 2013 Proceedings.

[5]  Kuei-Ann Wen,et al.  Integrated accelerometer with capacitance to digital interface circuit design based on monolithic 0.18μm CMOS MEMS technology , 2012, 2012 IEEE Sensors.

[6]  Suhwan Kim,et al.  A Delta–Sigma Interface Circuit for Capacitive Sensors With an Automatically Calibrated Zero Point , 2011, IEEE Transactions on Circuits and Systems II: Express Briefs.

[7]  N.M. Jokerst,et al.  Integrated Optical Sensor in a Digital Microfluidic Platform , 2008, IEEE Sensors Journal.

[8]  Daniel Teng,et al.  Digital microfluidic operations on micro-electrode array architecture , 2011, 2011 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems.

[9]  A. Matsuzawa,et al.  A 0.026mm2 capacitance-to-digital converter for biotelemetry applications using a charge redistribution technique , 2007, 2007 IEEE Asian Solid-State Circuits Conference.

[10]  S. Fan,et al.  Digital microfluidic operations on micro-electrode array architecture , 2011, NEMS 2011.

[11]  A. Baschirotto,et al.  A 828μW 1.8V 80dB dynamic-range readout interface for a MEMS capacitive microphone , 2008, ESSCIRC 2008 - 34th European Solid-State Circuits Conference.

[12]  Georges G. E. Gielen,et al.  A fully-digital, 0.3V, 270 nW capacitive sensor interface without external references , 2011, 2011 Proceedings of the ESSCIRC (ESSCIRC).

[13]  Youngcheol Chae,et al.  A 1.2V 8.3nJ energy-efficient CMOS humidity sensor for RFID applications , 2012, 2012 Symposium on VLSI Circuits (VLSIC).

[14]  Kofi A. A. Makinwa,et al.  A capacitance-to-digital converter for displacement sensing with 17b resolution and 20μs conversion time , 2012, 2012 IEEE International Solid-State Circuits Conference.

[15]  Gerard C. M. Meijer,et al.  An energy-efficient 15-bit capacitive sensor interface , 2011, 2011 Proceedings of the ESSCIRC (ESSCIRC).

[16]  Youngcheol Chae,et al.  A 1.8V 11μW CMOS smart humidity sensor for RFID sensing applications , 2011, IEEE Asian Solid-State Circuits Conference 2011.

[17]  Richard B. Fair,et al.  Digital microfluidics: is a true lab-on-a-chip possible? , 2007 .