Solid Lipid Nanoparticles for Drug Delivery

[1]  Gerhard Hielscher,et al.  Continuous contact- and contamination-free ultrasonic emulsification-a useful tool for pharmaceutical development and production. , 2006, Ultrasonics sonochemistry.

[2]  Heike Bunjes,et al.  Lipid nanoparticles for the delivery of poorly water‐soluble drugs , 2010, The Journal of pharmacy and pharmacology.

[3]  Structure and dynamics of drug-carrier systems as studied by parelectric spectroscopy. , 2007, Advanced drug delivery reviews.

[4]  R. Cavalli,et al.  Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats. , 2002, Journal of pharmaceutical sciences.

[5]  Walter Richter,et al.  Visualizing the structure of triglyceride nanoparticles in different crystal modifications. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[6]  R. Cavalli,et al.  Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats. , 2000, Pharmacological research.

[7]  S. Gohla,et al.  Medium scale production of solid lipid nanoparticles (SLN) by high pressure homogenization , 2002, Journal of microencapsulation.

[8]  R. Müller,et al.  Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery , 1995 .

[9]  S. Janez,et al.  The effect of lipophilicity of spin-labeled compounds on their distribution in solid lipid nanoparticle dispersions studied by electron paramagnetic resonance. , 2003, Journal of pharmaceutical sciences.

[10]  Goran T. Vladisavljevic,et al.  Preparation of monodisperse multiple emulsions at high production rates by multi-stage premix membrane emulsification , 2004 .

[11]  Björn Bergenståhl,et al.  Preparation of submicron drug particles in lecithin-stabilized o/w emulsions I. Model studies of the precipitation of cholesteryl acetate , 1992 .

[12]  G. Trägårdh,et al.  Membrane emulsification — a literature review , 2000 .

[13]  Y. Kuo,et al.  Physicochemical properties of nevirapine-loaded solid lipid nanoparticles and nanostructured lipid carriers. , 2011, Colloids and surfaces. B, Biointerfaces.

[14]  A. Almeida,et al.  Lipid nanoparticles containing oryzalin for the treatment of leishmaniasis. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[15]  A F Thünemann,et al.  Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals. , 2006, International journal of pharmaceutics.

[16]  R. Mumper,et al.  The Metabolism of Fatty Alcohols in Lipid Nanoparticles by Alcohol Dehydrogenase , 2006, Drug development and industrial pharmacy.

[17]  H. Kristensen,et al.  Preparation and purification of cationic solid lipid nanospheres--effects on particle size, physical stability and cell toxicity. , 2003, International journal of pharmaceutics.

[18]  R. Mumper,et al.  Genetic Immunization Using Nanoparticles Engineered from Microemulsion Precursors , 2002, Pharmaceutical Research.

[19]  R. Müller,et al.  Stability determination of solid lipid nanoparticles (SLN) in aqueous dispersion after addition of electrolyte. , 1999, Journal of microencapsulation.

[20]  R. Mumper,et al.  Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors , 2008, AAPS PharmSciTech.

[21]  C. M. Gupta,et al.  Tuftsin-bearing liposomes in treatment of macrophage-based infections. , 2000, Advanced drug delivery reviews.

[22]  H. Bunjes,et al.  Drug release from differently structured monoolein/poloxamer nanodispersions studied with differential pulse polarography and ultrafiltration at low pressure. , 2007, Journal of pharmaceutical sciences.

[23]  T. Unruh,et al.  Investigations on the melting behaviour of triglyceride nanoparticles , 2001 .

[24]  R. Müller,et al.  Spray-drying of solid lipid nanoparticles (SLN TM). , 1998, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[25]  R. Müller,et al.  Cyclosporine-loaded solid lipid nanoparticles (SLN): drug-lipid physicochemical interactions and characterization of drug incorporation. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[26]  Jing Qin,et al.  Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[27]  M. Ashokkumar,et al.  The use of ultrasonics for nanoemulsion preparation , 2008 .

[28]  M. Sznitowska,et al.  Bioavailability of diazepam from aqueous-organic solution, submicron emulsion and solid lipid nanoparticles after rectal administration in rabbits. , 2001, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[29]  M. Schubert,et al.  Structural investigations on lipid nanoparticles containing high amounts of lecithin. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[30]  H. Bunjes,et al.  Preparation of nanoemulsions and solid lipid nanoparticles by premix membrane emulsification. , 2012, Journal of pharmaceutical sciences.

[31]  J. Rathman,et al.  Optimization of β-carotene loaded solid lipid nanoparticles preparation using a high shear homogenization technique , 2009 .

[32]  Wei Wei,et al.  Uniform-sized PLA nanoparticles: preparation by premix membrane emulsification. , 2008, International journal of pharmaceutics.

[33]  S. Büttgenbach,et al.  The influence of customized geometries and process parameters on nanoemulsion and solid lipid nanoparticle production in microsystems , 2012 .

[34]  E. Dickinson,et al.  Colloidal dispersions based on solid lipids , 2001 .

[35]  M. Kukizaki.  Preparation of solid lipid microcapsules via solid-in-oil-in-water dispersions by premix membrane emulsification , 2009 .

[36]  H. Ronde,et al.  Preparation and Structure of a Water‐in‐Oil Cream Containing Lipid Nanoparticles , 1995 .

[37]  K. Westesen,et al.  Novel lipid-based colloidal dispersions as potential drug administration systems – expectations and reality , 2000 .

[38]  C. Alving.  Macrophages as targets for delivery of liposome-encapsulated antimicrobial agents , 1988 .

[39]  A. Barresi,et al.  Evaporative Drying of Aqueous Dispersions of Solid Lipid Nanoparticles , 2001, Drug development and industrial pharmacy.

[40]  J. Oh,et al.  Blood Compatibility of Cetyl Alcohol/Polysorbate-Based Nanoparticles , 2005, Pharmaceutical Research.

[41]  R. Sharma,et al.  Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[42]  Stephanus Büttgenbach,et al.  Effect of Microchannel Geometry on High‐Pressure Dispersion and Emulsification , 2011 .

[43]  R. Müller,et al.  Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products. , 1999, Journal of microencapsulation.

[44]  Russell J Mumper,et al.  Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP. , 2009, Cancer research.

[45]  C. Müller-Goymann,et al.  Characterization of solidified reverse micellar solutions (SRMS) and production development of SRMS-based nanosuspensions. , 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[46]  H. Korting,et al.  Glucocorticoid entrapment into lipid carriers--characterisation by parelectric spectroscopy and influence on dermal uptake. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[47]  R. Mumper,et al.  In-vivo efficacy of novel paclitaxel nanoparticles in paclitaxel-resistant human colorectal tumors. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[48]  M. Iso,et al.  Synthesis of polymeric microspheres employing SPG emulsification technique , 1994 .

[49]  M. Schubert,et al.  Characterisation of surface-modified solid lipid nanoparticles (SLN): influence of lecithin and nonionic emulsifier. , 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[50]  J. Rinehart,et al.  Uniformity of drug payload and its effect on stability of solid lipid nanoparticles containing an ester prodrug. , 2011, ACS nano.

[51]  J. A. Rothfus,et al.  Polymorphism and transformation energetics of saturated monoacid triglycerides from differential scanning calorimetry and theoretical modeling , 1983 .

[52]  Catherine Charcosset,et al.  Preparation of emulsions and particles by membrane emulsification for the food processing industry. , 2009 .

[53]  Jia-bi Zhu,et al.  Body Distribution of Camptothecin Solid Lipid Nanoparticles After Oral Administration , 1999, Pharmaceutical Research.

[54]  H. Bunjes,et al.  Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential , 1997 .

[55]  S. Majumdar,et al.  Injectable Lipid Emulsions—Advancements, Opportunities and Challenges , 2010, AAPS PharmSciTech.

[56]  R. Tan,et al.  Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables. , 2011, Colloids and surfaces. B, Biointerfaces.

[57]  R. Müller,et al.  Biodegradation of solid lipid nanoparticles as a function of lipase incubation time , 1996 .

[58]  M. Schäfer-Korting,et al.  Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[59]  H. Bunjes,et al.  Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions. , 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[60]  Junxian Yun,et al.  Formation of solid lipid nanoparticles in a microchannel system with a cross-shaped junction , 2008 .

[61]  R. Cavalli,et al.  Solid Lipid Nanoparticles in Lymph and Plasma After Duodenal Administration to Rats , 1998, Pharmaceutical Research.

[62]  M. Shimizu,et al.  Arterial‐injection chemotherapy for hepatocellular carcinoma using monodispersed poppy‐seed oil microdroplets containing fine aqueous vesicles of epirubicin. Initial medical application of a membrane‐emulsification technique , 1995, Cancer.

[63]  Hong Yuan,et al.  Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. , 2002, International journal of pharmaceutics.

[64]  Emilio Marengo,et al.  Effects of some experimental factors on the production process of solid lipid nanoparticles , 1996 .

[65]  R. Müller,et al.  Semisolid SLN dispersions for topical application: influence of formulation and production parameters on viscoelastic properties. , 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[66]  N. Krug,et al.  Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models , 2009, Inhalation toxicology.

[67]  G. Hause,et al.  Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles. , 2012, International journal of pharmaceutics.

[68]  R. Mumper,et al.  Gadolinium-Loaded Nanoparticles Engineered from Microemulsion Templates , 2002, Drug development and industrial pharmacy.

[69]  D. Coradini,et al.  The effect of formulation and concentration of cholesteryl butyrate solid lipid nanospheres (SLN) on NIH-H460 cell proliferation. , 2001, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[70]  R. Mumper,et al.  Coating of cationized protein on engineered nanoparticles results in enhanced immune responses. , 2002, International journal of pharmaceutics.

[71]  D. Fischer,et al.  The physical state of lipid nanoparticles influences their effect on in vitro cell viability. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[72]  K. Westesen,et al.  Investigations on solid lipid nanoparticles prepared by precipitation in o/w emulsions , 1996 .

[73]  V. Venkateswarlu,et al.  Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[74]  D. Mcclements,et al.  Influence of Polymorphic Transformations on Gelation of Tripalmitin Solid Lipid Nanoparticle Suspensions , 2008 .

[75]  R. Cavalli,et al.  Duodenal administration of solid lipid nanoparticles loaded with different percentages of tobramycin. , 2003, Journal of pharmaceutical sciences.

[76]  C. Porter,et al.  Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs , 2007, Nature Reviews Drug Discovery.

[77]  R. Cavalli,et al.  Study by X-ray powder diffraction and differential scanning calorimetry of two model drugs, phenothiazine and nifedipine, incorporated into lipid nanoparticles , 1995 .

[78]  V. Venkateswarlu,et al.  Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration , 2006, Journal of drug targeting.

[79]  R. Müller,et al.  Effect of lipid matrix and size of solid lipid nanoparticles (SLN) on the viability and cytokine production of macrophages. , 2002, International journal of pharmaceutics.

[80]  Stephan Scholl,et al.  A Microfluidic Approach for a Continuous Crystallization of Drug Carrier Nanoparticles , 2009 .

[81]  R. Mumper,et al.  Paclitaxel nanoparticles for the potential treatment of brain tumors. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[82]  R. Mumper,et al.  In Situ Blood–Brain Barrier Transport of Nanoparticles , 2003, Pharmaceutical Research.

[83]  Nicholas A Peppas,et al.  Targeted Nanodelivery of Drugs and Diagnostics. , 2010, Nano today.

[84]  A. Lamprecht,et al.  Selective Adhesion of Nanoparticles to Inflamed Tissue in Gastric Ulcers , 2009, Pharmaceutical Research.

[85]  R. Mumper,et al.  Nanotemplate Engineering of Cell Specific Nanoparticles , 2003 .

[86]  M. F. Malone,et al.  Predicting the Effect of the Homogenization Pressure on Emulsion Drop-Size Distributions , 2011 .

[87]  Kiyotaka Sato,et al.  Effects of Emulsifiers on Crystallization Behavior of Lipid Crystals in Nanometer-Size Oil-in-Water Emulsion Droplets , 2006 .

[88]  M. Schubert,et al.  Solvent injection as a new approach for manufacturing lipid nanoparticles--evaluation of the method and process parameters. , 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[89]  R. Boom,et al.  Premix emulsification: A review , 2010 .

[90]  Chong-Kook Kim,et al.  Preparation, characterization and in vitro cytotoxicity of paclitaxel-loaded sterically stabilized solid lipid nanoparticles. , 2007, Biomaterials.

[91]  V Jenning,et al.  Encapsulation of retinoids in solid lipid nanoparticles (SLN). , 2001, Journal of microencapsulation.

[92]  Heike Bunjes,et al.  Incorporation of the Model Drug Ubidecarenone into Solid Lipid Nanoparticles , 2001, Pharmaceutical Research.

[93]  B. Röder,et al.  Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[94]  Rainer H. Müller,et al.  Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN) dispersions , 1998 .

[95]  E. Blakely,et al.  Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme. , 2006, International journal of pharmaceutics.

[96]  E. Souto,et al.  Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[97]  R. Müller,et al.  Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[98]  K. Westesen,et al.  Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction , 1993 .

[99]  Rainer H Müller,et al.  The influence of solid lipid nanoparticles on skin hydration and viscoelasticity--in vivo study. , 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[100]  C. Müller-Goymann,et al.  Drug release and permeation studies of nanosuspensions based on solidified reverse micellar solutions (SRMS). , 2005, International journal of pharmaceutics.

[101]  R. Cavalli,et al.  Solid lipospheres of doxorubicin and idarubicin , 1993 .

[102]  H. Bunjes,et al.  Influence of emulsifiers on the crystallization of solid lipid nanoparticles. , 2003, Journal of pharmaceutical sciences.

[103]  Yaping Li,et al.  The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma. , 2009, Biomaterials.

[104]  M. Morari,et al.  Solid Lipid Nanoparticles as Delivery Systems for Bromocriptine , 2008, Pharmaceutical Research.

[105]  K. Mäder,et al.  Solid lipid nanoparticles: production, characterization and applications. , 2001, Advanced drug delivery reviews.

[106]  T. Unruh,et al.  Investigation on the flow behavior of dispersions of solid triglyceride nanoparticles. , 2004, International journal of pharmaceutics.

[107]  R. Müller,et al.  Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[108]  J. Rinehart,et al.  Physicochemical characterization of nanotemplate engineered solid lipid nanoparticles. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[109]  Heike Bunjes,et al.  Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering. , 2007, Advanced drug delivery reviews.

[110]  Robert Gurny,et al.  Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[111]  Heike Bunjes,et al.  Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the alpha-modification. , 2009, Molecular pharmaceutics.

[112]  Yan Li,et al.  The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice. , 2008, International journal of biological macromolecules.

[113]  G. Giammona,et al.  Preparation and Characterization of Solid Lipid Nanoparticles Containing Cloricromene , 2003, Drug delivery.

[114]  Mhj Koch,et al.  Self-Assembly of Triglyceride Nanocrystals in Suspension , 2002 .

[115]  G. Zhai,et al.  Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[116]  J. Rinehart,et al.  Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants: Optimization and In Vitro Characterization , 2008, The AAPS Journal.

[117]  F. Chemat,et al.  High power ultrasound effects on lipid oxidation of refined sunflower oil. , 2004, Ultrasonics sonochemistry.

[118]  N Hussain,et al.  Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. , 2001, Advanced drug delivery reviews.

[119]  M. Hashida,et al.  Long circulating emulsion carrier systems for highly lipophilic drugs. , 1994, Biological & pharmaceutical bulletin.

[120]  Y. Carpentier,et al.  Advances in Intravenous Lipid Emulsions , 2000, World Journal of Surgery.

[121]  C. Washington,et al.  Partition of antimicrobial additives in an intravenous emulsion and their effect on emulsion physical stability. , 2005, International journal of pharmaceutics.

[122]  Kan-ich Suzuki,et al.  Characteristics of the Membrane Emulsification Method Combined with Preliminary Emulsification for Preparing Corn Oil-in-Water Emulsions. , 1996 .

[123]  D. Chirio,et al.  Influence of α- and γ- cyclodextrin lipophilic derivatives on curcumin-loaded SLN , 2009 .

[124]  R. Müller,et al.  Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages. , 2001, International journal of pharmaceutics.

[125]  H. Fessi,et al.  Preparation of solid lipid nanoparticles using a membrane contactor. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[126]  Liandong Hu,et al.  Preparation and Enhanced Oral Bioavailability of Cryptotanshinone-Loaded Solid Lipid Nanoparticles , 2010, AAPS PharmSciTech.

[127]  R. Cavalli,et al.  Preparation and characterization of solid lipid nanospheres containing paclitaxel. , 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[128]  Thomas Schmidts,et al.  Membrane-assisted production of S1P loaded SLNs for the treatment of acne vulgaris , 2010 .

[129]  L. Rizza,et al.  Characterization of indomethacin-loaded lipid nanoparticles by differential scanning calorimetry. , 2005, International journal of pharmaceutics.

[130]  Wenzhong Zhou,et al.  Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids. , 2011, Colloids and surfaces. B, Biointerfaces.

[131]  J. Kristl,et al.  Optimization of procedure parameters and physical stability of solid lipid nanoparticles in dispersions , 1998 .

[132]  Yingying Zhang,et al.  Solvent injection-lyophilization of tert-butyl alcohol/water cosolvent systems for the preparation of drug-loaded solid lipid nanoparticles. , 2010, Colloids and surfaces. B, Biointerfaces.

[133]  S. Zeng,et al.  Studies on oral absorption of stearic acid SLN by a novel fluorometric method. , 2007, Colloids and surfaces. B, Biointerfaces.

[134]  G. Giammona,et al.  Employment of cationic solid-lipid nanoparticles as RNA carriers. , 2007, Bioconjugate chemistry.

[135]  M. Milek,et al.  Surface active stabilizer tyloxapol in colloidal dispersions exerts cytostatic effects and apoptotic dismissal of cells. , 2008, Toxicology and applied pharmacology.

[136]  R. Bittl,et al.  Interaction of drug molecules with carrier systems as studied by parelectric spectroscopy and electron spin resonance. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[137]  Heike Bunjes,et al.  Crystallization tendency and polymorphic transitions in triglyceride nanoparticles , 1996 .

[138]  Helmar Schubert,et al.  Effect of Dynamic Interfacial Tension on the Emulsification Process Using Microporous, Ceramic Membranes☆ , 1998 .

[139]  Liandong Hu,et al.  Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs , 2004, The Journal of pharmacy and pharmacology.

[140]  R. Müller,et al.  Influence of different parameters on reconstitution of lyophilized SLN. , 2000, International journal of pharmaceutics.

[141]  P. Sylvester,et al.  Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy ((1)H NMR). , 2010, Colloids and surfaces. B, Biointerfaces.

[142]  M. Koch,et al.  Effect of Particle Size on Colloidal Solid Triglycerides , 2000 .

[143]  C. Bocca,et al.  Phagocytic uptake of fluorescent stealth and non-stealth solid lipid nanoparticles , 1998 .

[144]  R. Boom,et al.  Polylactide microspheres prepared by premix membrane emulsification—Effects of solvent removal rate , 2008 .

[145]  R. Müller,et al.  Pellets as carriers of solid lipid nanoparticles (SLN) for oral administration of drugs , 1999 .

[146]  S. Kawakami,et al.  Disposition characteristics of emulsions and incorporated drugs after systemic or local injection. , 2000, Advanced drug delivery reviews.

[147]  G Pohlmann,et al.  A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[148]  M. Trotta,et al.  Sterilization and freeze-drying of drug-free and drug-loaded solid lipid nanoparticles , 1997 .

[149]  G. Abdelbary,et al.  Diazepam-Loaded Solid Lipid Nanoparticles: Design and Characterization , 2009, AAPS PharmSciTech.

[150]  R. Mumper,et al.  Intranasal administration of plasmid DNA‐coated nanoparticles results in enhanced immune responses , 2002, The Journal of pharmacy and pharmacology.

[151]  Junxian Yun,et al.  Preparation of solid lipid nanoparticles in co-flowing microchannels , 2008 .

[152]  M. Rawat,et al.  Studies on binary lipid matrix based solid lipid nanoparticles of repaglinide: in vitro and in vivo evaluation. , 2011, Journal of pharmaceutical sciences.

[153]  D. Bansal,et al.  Design and development of solid lipid nanoparticles for topical delivery of an anti-fungal agent , 2010, Drug delivery.

[154]  R. Müller,et al.  Enzymatic Degradation of Dynasan 114 SLN – Effect of Surfactants and Particle Size , 2002 .

[155]  T. Dutta,et al.  Characterization and in vitro assessment of paclitaxel loaded lipid nanoparticles formulated using modified solvent injection technique. , 2009, Die Pharmazie.

[156]  Qiang Zhang,et al.  In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel. , 2001, Chemical & pharmaceutical bulletin.

[157]  Alireza Vatanara,et al.  Cationic solid lipid nanoparticles loaded by cysteine proteinase genes as a novel anti-leishmaniasis DNA vaccine delivery system: characterization and in vitro evaluations. , 2010, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[158]  Heike Bunjes,et al.  Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems. , 2011, International journal of pharmaceutics.

[159]  V. Venkateswarlu,et al.  Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[160]  Xiangliang Yang,et al.  The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle. , 2005, Pharmacological research.

[161]  W. Weyenberg,et al.  Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application. , 2007, International journal of pharmaceutics.

[162]  S M Moghimi,et al.  Long-circulating and target-specific nanoparticles: theory to practice. , 2001, Pharmacological reviews.

[163]  Rohan V. Tikekar,et al.  Effect of physical state (solid vs. liquid) of lipid core on the rate of transport of oxygen and free radicals in solid lipid nanoparticles and emulsion , 2011 .

[164]  R. Müller,et al.  Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with poloxamine 908 and poloxamer 407. , 1996, Journal of drug targeting.

[165]  Paul R. Lockman,et al.  In Vivo and in Vitro Assessment of Baseline Blood-Brain Barrier Parameters in the Presence of Novel Nanoparticles , 2003, Pharmaceutical Research.

[166]  Shi-Ming Liu,et al.  Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. , 2011, International journal of pharmaceutics.

[167]  S. Benita,et al.  A new in vitro technique for the evaluation of drug release profile from colloidal carriers - ultrafiltration technique at low pressure , 1993 .

[168]  Schwarz,et al.  Freeze-drying of drug-free and drug-loaded solid lipid nanoparticles (SLN). , 1997, International journal of pharmaceutics.

[169]  Sandeep Nema,et al.  Excipients and Their Role in Approved Injectable Products: Current Usage and Future Directions , 2011, PDA Journal of Pharmaceutical Science and Technology.

[170]  R. Müller,et al.  Electrolyte- and pH-stabilities of aqueous solid lipid nanoparticle (SLN) dispersions in artificial gastrointestinal media. , 2001, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[171]  K. Westesen,et al.  Thermoanalysis of the recrystallization process of melt-homogenized glyceride nanoparticles , 1994 .

[172]  H. Hauser.  The effect of ultrasonic irradiation on the chemical structure of egg lecithin. , 1971, Biochemical and biophysical research communications.

[173]  M. Ashokkumar,et al.  Minimising oil droplet size using ultrasonic emulsification. , 2009, Ultrasonics sonochemistry.

[174]  H. Bunjes,et al.  Effects of surfactants on the crystallization and polymorphism of lipid nanoparticles , 2002 .

[175]  S. Wartewig,et al.  Solid Lipid Nanoparticles (SLN) and Oil-Loaded SLN Studied by Spectrofluorometry and Raman Spectroscopy , 2005, Pharmaceutical Research.

[176]  R. Müller,et al.  Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase. , 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[177]  M. Shimizu,et al.  Membrane Emulsification by Microporous Glass , 1992 .

[178]  J. Kristl,et al.  Influence of spin probe structure on its distribution in SLN dispersions. , 2000, International journal of pharmaceutics.

[179]  M. Trotta,et al.  Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. , 2003, International journal of pharmaceutics.

[180]  E. Souto,et al.  Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): high pressure homogenization versus ultrasound. , 2011, Colloids and surfaces. B, Biointerfaces.

[181]  D. Driscoll,et al.  Lipid Injectable Emulsions: Pharmacopeial and Safety Issues , 2006, Pharmaceutical Research.

[182]  Y. Cai,et al.  Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[183]  M. Eandi,et al.  Cytotoxicity of anticancer drugs incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[184]  R. Macdonald,et al.  Small-volume extrusion apparatus for preparation of large, unilamellar vesicles. , 1991, Biochimica et biophysica acta.

[185]  Hatem Fessi,et al.  Preparation of Indomethacin-Loaded Lipid Particles by Membrane Emulsification , 2011 .

[186]  A. Mishra,et al.  Oral solid compritol 888 ATO nanosuspension of simvastatin: optimization and biodistribution studies , 2011, Drug development and industrial pharmacy.

[187]  Vemula Satyanarayana,et al.  Preparation, characterization, and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles , 2007, AAPS PharmSciTech.

[188]  Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants II: Role of Plasma Esterases in Drug Release , 2009, The AAPS Journal.

[189]  Karsten Mäder,et al.  Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[190]  C Washington,et al.  Drug release from microdisperse systems: a critical review , 1990 .

[191]  Yamsani Madhusudan Rao,et al.  Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics. , 2007, International journal of pharmaceutics.

[192]  W Mehnert,et al.  Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism. , 1998, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[193]  K. Mäder,et al.  Physicochemical Investigations on Solid Lipid Nanoparticles and on Oil-Loaded Solid Lipid Nanoparticles: A Nuclear Magnetic Resonance and Electron Spin Resonance Study , 2003, Pharmaceutical Research.

[194]  M. Schäfer-Korting,et al.  Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[195]  Junxian Yun,et al.  Continuous production of solid lipid nanoparticles by liquid flow-focusing and gas displacing method in microchannels , 2009 .

[196]  Alexander T. Florence,et al.  The Oral Absorption of Micro- and Nanoparticulates: Neither Exceptional Nor Unusual , 1997, Pharmaceutical Research.

[197]  Jürgen Lademann,et al.  Follicular transport route--research progress and future perspectives. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[198]  G. Giammona,et al.  Solid Lipid Nanoparticles Containing Tamoxifen Characterization and In Vitro Antitumoral Activity , 2005, Drug delivery.

[199]  D. Mcclements,et al.  Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles. , 2009, Journal of agricultural and food chemistry.

[200]  H. Fessi,et al.  Influence of the Formulation for Solid Lipid Nanoparticles Prepared with a Membrane Contactor , 2006, Pharmaceutical development and technology.

[201]  H. Bunjes,et al.  Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[202]  Jia-You Fang,et al.  Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: pharmacokinetic and behavioral evaluations. , 2011, Journal of pharmaceutical sciences.

[203]  R. Müller,et al.  Peptide-loaded solid lipid nanoparticles (SLN): Influence of production parameters , 1997 .

[204]  Heike Bunjes,et al.  Flow cytometry as a new approach to investigate drug transfer between lipid particles. , 2010, Molecular pharmaceutics.

[205]  Jun Fang,et al.  The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. , 2011, Advanced drug delivery reviews.

[206]  Y. Kuo,et al.  Solid lipid nanoparticles comprising internal Compritol 888 ATO, tripalmitin and cacao butter for encapsulating and releasing stavudine, delavirdine and saquinavir. , 2011, Colloids and surfaces. B, Biointerfaces.

[207]  M. Koch,et al.  Observation of Size-Dependent Melting in Lipid Nanoparticles , 1999 .

[208]  B. Boyd.  Characterisation of drug release from cubosomes using the pressure ultrafiltration method. , 2003, International journal of pharmaceutics.

[209]  R. Müller,et al.  Solid lipid nanoparticles (SLN) as potential carrier for human use: interaction with human granulocytes , 1997 .

[210]  Giorgio Rovero,et al.  Scale-Up and Optimization of an Evaporative Drying Process Applied to Aqueous Dispersions of Solid Lipid Nanoparticles , 2003, Pharmaceutical development and technology.

[211]  C. Washington,et al.  Release rate measurements of model hydrophobic solutes from submicron triglyceride emulsions , 1995 .

[212]  C. Washington,et al.  Evaluation of non-sink dialysis methods for the measurement of drug release from colloids: effects of drug partition , 1989 .

[213]  S M Moghimi,et al.  Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective. , 2012, Annual review of pharmacology and toxicology.

[214]  G. Giammona,et al.  Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution. , 2010, Nanomedicine.

[215]  R. Müller,et al.  Investigation on the viscoelastic properties of lipid based colloidal drug carriers. , 2000, International journal of pharmaceutics.

[216]  Rainer H. Müller,et al.  Cytotoxicity of Solid Lipid Nanoparticles as a Function of the Lipid Matrix and the Surfactant , 1997, Pharmaceutical Research.

[217]  S. Gohla,et al.  Production of solid lipid nanoparticles (SLN): scaling up feasibilities , 2002, Journal of microencapsulation.

[218]  M. Martín-Pastor,et al.  Application of NMR spectroscopy to the characterization of PEG-stabilized lipid nanoparticles. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[219]  D. Chevalier-Lucia,et al.  Characteristics of submicron emulsions prepared by ultra-high pressure homogenisation: Effect of chilled or frozen storage , 2009 .

[220]  R. Cavalli,et al.  Intravenous Administration to Rabbits of Non-stealth and Stealth Doxorubicin-loaded Solid Lipid Nanoparticles at Increasing Concentrations of Stealth Agent: Pharmacokinetics and Distribution of Doxorubicin in Brain and Other Tissues , 2002, Journal of drug targeting.

[221]  R. Müller,et al.  Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)--effect of surfactants, storage time and crystallinity. , 2002, International journal of pharmaceutics.

[222]  Y. Kuo,et al.  Transport of stavudine, delavirdine, and saquinavir across the blood-brain barrier by polybutylcyanoacrylate, methylmethacrylate-sulfopropylmethacrylate, and solid lipid nanoparticles. , 2007, International journal of pharmaceutics.

[223]  R. Cavalli,et al.  Incorporation of cyclosporin A in solid lipid nanoparticles (SLN). , 2002, International journal of pharmaceutics.

[224]  E. Marengo,et al.  Scale-up of the preparation process of solid lipid nanospheres. Part I. , 2000, International journal of pharmaceutics.

[225]  Chong-K. Kim,et al.  Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid. , 2002, International journal of pharmaceutics.

[226]  Yajiang Yang,et al.  Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. , 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[227]  W. Mehnert,et al.  Atomic Force Microscopy Studies of Solid Lipid Nanoparticles , 1996, Pharmaceutical Research.

[228]  A. Barresi,et al.  Preparation of solid lipid particles by membrane emulsification—Influence of process parameters , 2009 .

[229]  T. Unruh,et al.  Investigation on Particle Self-Assembly in Solid Lipid-Based Colloidal Drug Carrier Systems , 2004, Pharmaceutical Research.

[230]  R. Müller,et al.  Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles. , 2001, International journal of pharmaceutics.

[231]  D. Driscoll,et al.  Lipid injectable emulsions: 2006. , 2006, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[232]  R. Cavalli,et al.  Biodistribution of Stealth and Non‐stealth Solid Lipid Nanospheres after Intravenous Administration to Rats , 2000, The Journal of pharmacy and pharmacology.

[233]  K. Mäder,et al.  Isostatic Ultra-High-Pressure Effects on Supercooled Melts in Colloidal Triglyceride Dispersions , 2005, Pharmaceutical Research.

[234]  K. Westesen,et al.  Investigation of the gel formation of phospholipid-stabilized solid lipid nanoparticles , 1997 .

[235]  S. Büttgenbach,et al.  Novel 3D manufacturing method combining microelectrial discharge machining and electrochemical polishing , 2012 .