Enhancement of thymidine production in E. coli by eliminating repressors regulating the carbamoyl phosphate synthetase operon

[1]  W. Jang,et al.  High NADPH/NADP+ ratio improves thymidine production by a metabolically engineered Escherichia coli strain. , 2010, Journal of biotechnology.

[2]  W. Jang,et al.  Thymidine production by overexpressing NAD+ kinase in an Escherichia coli recombinant strain , 2009, Biotechnology Letters.

[3]  W. Jang,et al.  Fermentative Production of Thymidine by a Metabolically Engineered Escherichia coli Strain , 2009, Applied and Environmental Microbiology.

[4]  C. Turnbough,et al.  Regulation of Pyrimidine Biosynthetic Gene Expression in Bacteria: Repression without Repressors , 2008, Microbiology and Molecular Biology Reviews.

[5]  A. Ishihama,et al.  RutR is the uracil/thymine‐sensing master regulator of a set of genes for synthesis and degradation of pyrimidines , 2007, Molecular microbiology.

[6]  Jung-Kul Lee,et al.  Thymidine production by Corynebacterium ammoniagenes mutants , 2005 .

[7]  D. Gigot,et al.  Purine and pyrimidine-specific repression of the Escherichia coli carAB operon are functionally and structurally coupled. , 2004, Journal of molecular biology.

[8]  Hyeon-Cheol Lee,et al.  Overproduction of thymidine by recombinant Brevibacterium helvolum amplified with thymidine monophosphate phosphohydrolase gene from bacteriophage PBS2 , 2004, Biotechnology Letters.

[9]  D. Gigot,et al.  Integration Host Factor (IHF) modulates the expression of the pyrimidine-specific promoter of the carAB operons of Escherichia coli K12 and Salmonella typhimurium LT2 , 1993, Molecular and General Genetics MGG.

[10]  P. Couvreur,et al.  I. Arginine. , 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[11]  Shamim Ahmad,et al.  Screening of microbes, isolation, genetic manipulation, and physiological optimization of Brevibacterium helvolum to produce and excrete thymidine and deoxyuridine in high concentrations. , 2000, The Journal of general and applied microbiology.

[12]  B. Wanner,et al.  One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[13]  K. Murphy,et al.  PCR-mediated gene replacement in Escherichia coli. , 2000, Gene.

[14]  D. Gigot,et al.  pyrH-encoded UMP-kinase directly participates in pyrimidine-specific modulation of promoter activity in Escherichia coli. , 1998, Journal of molecular biology.

[15]  N. Glansdorff,et al.  The arginine repressor of Escherichia coli K-12 makes direct contacts to minor and major groove determinants of the operators. , 1998, Journal of molecular biology.

[16]  C. Turnbough,et al.  Regulation of carAB Expression inEscherichia coli Occurs in Part through UTP-Sensitive Reiterative Transcription , 1998, Journal of bacteriology.

[17]  D. Gigot,et al.  carP, involved in pyrimidine regulation of the Escherichia coli carbamoylphosphate synthetase operon encodes a sequence-specific DNA-binding protein identical to XerB and PepA, also required for resolution of ColEI multimers. , 1995, Journal of molecular biology.

[18]  S. Tsen Chemostat selection of Escherichia coli mutants secreting thymidine, cytosine, uracil, guanine, and thymine , 1994, Applied Microbiology and Biotechnology.

[19]  Broder,et al.  Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[20]  N. Glansdorff,et al.  DNA sequence of the carA gene and the control region of carAB: tandem promoters, respectively controlled by arginine and the pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase in Escherichia coli K-12. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[21]  P. Stragier,et al.  Multiple regulatory signals in the control region of the Escherichia coli carAB operon. , 1984, Proceedings of the National Academy of Sciences of the United States of America.