Role of AgNORs in Oral Lesions-A Review

The biologic behavior of the oral lesions can be determined by their active phases of cell division, cells entering the cell cycle and their proliferation. AgNORs (argyrophilic nucleolar organizer regions) staining is the one of the cytochemical technique used to evaluate the cell proliferation of oral lesions. Tumor cells in premalignant and malignant conditions usually exhibits a rise in synthesis of abnormal proteins and proportionately there is a increase in the AgNOR material. The aim of this study was to review the concepts of proliferative activity of cells of malignant and premalignant conditions through the AgNORs staining procedure and thereby proving the usefulness of AgNORs in diagnosing the oral lesions.

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