Removal of H₂O₂ and generation of superoxide radical: role of cytochrome c and NADH.

[1]  A. Pyle,et al.  Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. , 2011, Cell stem cell.

[2]  M. Fabian,et al.  Ferricytochrome c protects mitochondrial cytochrome c oxidase against hydrogen peroxide-induced oxidative damage. , 2010, Free radical biology & medicine.

[3]  D. Sideris,et al.  Oxidative protein folding in the mitochondrial intermembrane space. , 2010, Antioxidants & redox signaling.

[4]  Chunxiang Zhang,et al.  Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. , 2010, Cardiovascular research.

[5]  Antonis A Armoundas,et al.  Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters , 2010, Proceedings of the National Academy of Sciences.

[6]  J. Hiltunen,et al.  Peroxisomes are oxidative organelles. , 2010, Antioxidants & redox signaling.

[7]  Manisha N. Patel,et al.  Respiration-dependent H2O2 Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System* , 2010, The Journal of Biological Chemistry.

[8]  Rouslan G. Efremov,et al.  The architecture of respiratory complex I , 2010, Nature.

[9]  W. Sivitz,et al.  Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. , 2010, Antioxidants & redox signaling.

[10]  M. Martí,et al.  Molecular basis for the electric field modulation of cytochrome C structure and function. , 2009, Journal of the American Chemical Society.

[11]  R. Ferrari,et al.  Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart. , 2009, Cardiovascular research.

[12]  G. Paradies,et al.  Melatonin inhibits cardiolipin peroxidation in mitochondria and prevents the mitochondrial permeability transition and cytochrome c release. , 2009, Free radical biology & medicine.

[13]  G. La Piana,et al.  Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system. , 2009, Archives of biochemistry and biophysics.

[14]  P. Coates,et al.  Neurodegeneration and peroxidases , 2009, Neurobiology of Aging.

[15]  P. Kochanek,et al.  Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. , 2009, Free radical biology & medicine.

[16]  M. Goligorsky,et al.  Mitochondria and reactive oxygen species. , 2009, Hypertension.

[17]  L. Szweda,et al.  Mitochondrial superoxide production and respiratory activity: biphasic response to ischemic duration. , 2009, Archives of biochemistry and biophysics.

[18]  D. Green,et al.  Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells , 2009, Proceedings of the National Academy of Sciences.

[19]  A. Bhatnagar,et al.  Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal. , 2009, The Biochemical journal.

[20]  R. Radi,et al.  Nitration of Solvent-exposed Tyrosine 74 on Cytochrome c Triggers Heme Iron-Methionine 80 Bond Disruption , 2009, Journal of Biological Chemistry.

[21]  C. Zazueta,et al.  Relationship between oxidative stress and mitochondrial function in the post-conditioned heart , 2008, Journal of bioenergetics and biomembranes.

[22]  M. Deshmukh,et al.  Glucose Metabolism Inhibits Apoptosis in Neurons and Cancer Cells by Redox Inactivation of Cytochrome c , 2008, Nature Cell Biology.

[23]  C. Winterbourn,et al.  Reconciling the chemistry and biology of reactive oxygen species. , 2008, Nature chemical biology.

[24]  S. Sharkis,et al.  A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. , 2007, Blood.

[25]  J. Zweier,et al.  Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention. , 2007, Free radical biology & medicine.

[26]  P. Pelicci,et al.  Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? , 2007, Nature Reviews Molecular Cell Biology.

[27]  R. Stocker,et al.  Hydrogen Peroxide Promotes Endothelial Dysfunction by Stimulating Multiple Sources of Superoxide Anion Radical Production and Decreasing Nitric Oxide Bioavailability , 2007, Cellular Physiology and Biochemistry.

[28]  J. Pouysségur,et al.  Oxygen, a source of life and stress , 2007, FEBS letters.

[29]  Y. Ido.  Pyridine nucleotide redox abnormalities in diabetes. , 2007, Antioxidants & redox signaling.

[30]  E. Gottlieb,et al.  Cardiolipin: Setting the beat of apoptosis , 2007, Apoptosis.

[31]  J. Zweier,et al.  Evidence for the Pathophysiological Role of Endogenous Methylarginines in Regulation of Endothelial NO Production and Vascular Function* , 2007, Journal of Biological Chemistry.

[32]  A. V. Brusnichkin,et al.  Cardiolipin activates cytochrome c peroxidase activity since it facilitates H2O2 access to heme , 2006, Biochemistry (Moscow).

[33]  E. Margoliash,et al.  Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[34]  J. Zweier,et al.  The role of oxidants and free radicals in reperfusion injury. , 2006, Cardiovascular research.

[35]  S. Sollott,et al.  Mitochondrial ROS-induced ROS release: an update and review. , 2006, Biochimica et biophysica acta.

[36]  I. Kurnikov,et al.  Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes. , 2006, Biochemistry.

[37]  E. Lander,et al.  Reactive oxygen species have a causal role in multiple forms of insulin resistance , 2006, Nature.

[38]  S. Cortassa,et al.  Mitochondrial ion channels: gatekeepers of life and death. , 2005, Physiology.

[39]  B. Zhivotovsky,et al.  Cardiolipin oxidation sets cytochrome c free , 2005, Nature chemical biology.

[40]  Qing Zhao,et al.  Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors , 2005, Nature chemical biology.

[41]  A. Slominski,et al.  A novel metabolic pathway of melatonin: oxidation by cytochrome C. , 2005, Biochemistry.

[42]  J. Zweier,et al.  Endothelium-Derived Nitric Oxide Regulates Postischemic Myocardial Oxygenation and Oxygen Consumption by Modulation of Mitochondrial Electron Transport , 2005, Circulation.

[43]  Jeffrey Robbins,et al.  Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death , 2005, Nature.

[44]  J. Zweier,et al.  Cancer chemopreventive oltipraz generates superoxide anion radical. , 2005, Archives of biochemistry and biophysics.

[45]  Jianfei Jiang,et al.  Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine. , 2004, Free radical biology & medicine.

[46]  Jianjie Ma,et al.  Nuclear Translocation of Cytochrome c during Apoptosis* , 2004, Journal of Biological Chemistry.

[47]  Jianxing Xu,et al.  The operation of the alternative electron-leak pathways mediated by cytochrome c in mitochondria. , 2004, Biochemical and biophysical research communications.

[48]  X. Leverve,et al.  Opening of the Mitochondrial Permeability Transition Pore Induces Reactive Oxygen Species Production at the Level of the Respiratory Chain Complex I* , 2004, Journal of Biological Chemistry.

[49]  V. Skulachev,et al.  Cytochrome c, an ideal antioxidant. , 2003, Biochemical Society transactions.

[50]  N. Kulagina,et al.  Monitoring hydrogen peroxide in the extracellular space of the brain with amperometric microsensors. , 2003, Analytical chemistry.

[51]  P. Wardman,et al.  Evidence for the Role of a Peroxidase Compound I-type Intermediate in the Oxidation of Glutathione, NADH, Ascorbate, and Dichlorofluorescin by Cytochrome c/H2O2 , 2003, Journal of Biological Chemistry.

[52]  A. Kowaltowski,et al.  H(2)O(2) generation in Saccharomyces cerevisiae respiratory pet mutants: effect of cytochrome c. , 2003, Free radical biology & medicine.

[53]  M. Consalvo,et al.  Cytochrome c-induced cytosolic nicotinamide adenine dinucleotide oxidation, mitochondrial permeability transition, and apoptosis. , 2003, Archives of biochemistry and biophysics.

[54]  Jianxing Xu,et al.  Effect of Cytochrome c on the Generation and Elimination of O 2 ⨪ and H2O2 in Mitochondria* , 2003, The Journal of Biological Chemistry.

[55]  S. Pietri,et al.  Spin trapping of superoxide in the presence of β-cyclodextrins , 2002 .

[56]  M. Brand,et al.  Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain* , 2002, The Journal of Biological Chemistry.

[57]  L. Deterding,et al.  Protein Oxidation of Cytochrome c by Reactive Halogen Species Enhances Its Peroxidase Activity* , 2002, The Journal of Biological Chemistry.

[58]  M. Grant,et al.  Time course of NADH oxidase, inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ/WOR rat. , 2002, Nitric oxide : biology and chemistry.

[59]  C. Kim,et al.  Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. , 2002, Diabetes.

[60]  Jared Rutter,et al.  Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors , 2001, Science.

[61]  J. Pullar,et al.  Glutathione Oxidation by Hypochlorous Acid in Endothelial Cells Produces Glutathione Sulfonamide as a Major Product but Not Glutathione Disulfide* , 2001, The Journal of Biological Chemistry.

[62]  E. Cadenas,et al.  Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state. , 2001, Free radical biology & medicine.

[63]  M. Borgers,et al.  Apoptosis in the heart: about programmed cell death and survival. , 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[64]  Steven J. Sollott,et al.  Reactive Oxygen Species (Ros-Induced) Ros Release , 2000, The Journal of experimental medicine.

[65]  J. Vijg,et al.  Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei. , 2000, Free radical biology & medicine.

[66]  R. Ferrari,et al.  New insights on myocardial pyridine nucleotides and thiol redox state in ischemia and reperfusion damage. , 2000, Cardiovascular research.

[67]  K. Davies,et al.  Mitochondrial free radical generation, oxidative stress, and aging. , 2000, Free radical biology & medicine.

[68]  B. Freeman,et al.  Cytochrome c Nitration by Peroxynitrite* , 2000, The Journal of Biological Chemistry.

[69]  V. Skulachev,et al.  The antioxidant functions of cytochrome c , 1999, FEBS letters.

[70]  M. Poot,et al.  Detection of changes in mitochondrial function during apoptosis by simultaneous staining with multiple fluorescent dyes and correlated multiparameter flow cytometry. , 1999, Cytometry.

[71]  J. McManaman,et al.  Alcohol-induced breast cancer: a proposed mechanism. , 1999, Free radical biology & medicine.

[72]  N. Pfanner,et al.  The yeast mitochondrial intermembrane space: purification and analysis of two distinct fractions. , 1998, Analytical biochemistry.

[73]  Dean P. Jones,et al.  Superoxide in Apoptosis , 1998, The Journal of Biological Chemistry.

[74]  H. Forman,et al.  On the virtual existence of superoxide anions in mitochondria: thoughts regarding its role in pathophysiology , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[75]  D. Green,et al.  The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.

[76]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[77]  J. Zweier,et al.  Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart , 1996, The Journal of Biological Chemistry.

[78]  D. Harrison,et al.  Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. , 1996, The Journal of clinical investigation.

[79]  K. Schönheit,et al.  Oxidation of cytosolic NADH via complex I of heart mitochondria. , 1996, Archives of biochemistry and biophysics.

[80]  G. Kroemer,et al.  Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death , 1995, The Journal of experimental medicine.

[81]  H. Swartz,et al.  Lithium phthalocyanine: a probe for electron paramagnetic resonance oximetry in viable biological systems. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[82]  I. Silver,et al.  Oxygen in mammalian tissue: methods of measurement and affinities of various reactions. , 1991, The American journal of physiology.

[83]  M. Borgers,et al.  Stunned myocardium has increased mitochondrial NADH oxidase and ATPase activities. , 1991, Cardioscience.

[84]  M. Borgers,et al.  Mitochondrial hydrogen peroxide generation by NADH-oxidase activity following regional myocardial ischemia in the dog. , 1989, Journal of molecular and cellular cardiology.

[85]  J. Zweier.  Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury. , 1988, The Journal of biological chemistry.

[86]  L. Forni,et al.  Thiyl and phenoxyl free radicals and NADH. Direct observation of one-electron oxidation. , 1986, The Biochemical journal.

[87]  J. Williamson,et al.  Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats. , 1977, Archives of biochemistry and biophysics.

[88]  I. Taub,et al.  Free radical reduction of ferricytochrome-C. , 1975, Biochemical and biophysical research communications.

[89]  J. Daly.  A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish , 2010 .

[90]  Brian O'Rourke,et al.  Mitochondrial oscillations in physiology and pathophysiology. , 2008, Advances in experimental medicine and biology.

[91]  D. Leibfritz,et al.  Free radicals and antioxidants in normal physiological functions and human disease. , 2007, The international journal of biochemistry & cell biology.

[92]  B. Freeman,et al.  Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration. , 2004, Archives of biochemistry and biophysics.

[93]  Jonathan S. Weissman,et al.  Oxidative protein folding in eukaryotes: mechanisms and consequences , 2004 .

[94]  F. Murad,et al.  Nitric oxide (NO)--biogeneration, regulation, and relevance to human diseases. , 2003, Frontiers in bioscience : a journal and virtual library.

[95]  F. Murad,et al.  Nitric oxide (NO): Biogeneration, regulation, and relevence to human diseases , 2003 .

[96]  S. Pietri,et al.  Spin trapping of superoxide in the presence of beta-cyclodextrins. , 2002, Chemical communications.

[97]  G. Buettner.  On the reaction of superoxide with DMPO/.OOH. , 1990, Free radical research communications.

[98]  B. Corkey,et al.  Assay of citric acid cycle intermediates and related compounds--update with tissue metabolite levels and intracellular distribution. , 1979, Methods in enzymology.