Treatment Outcomes of Third-generation Cephalosporin-susceptible and Resistant Enterobacteriaceae Infection in Dogs and Cats

SUMMARY In Enterobacteriaceae isolated from bacteria-infected dogs and cats in one hospital, 18% of Escherichia coli (32 strains), 44% of Klebsiella pneumoniae (14 strains), 43% of Citrobacter spp. (three strains), 2% of Proteus mirabilis (one strain), and 12% of Enterobacter spp. (three strains) were third-generation cephalosporin (3rdCEP)-resistant. The 3rdCEP-sensitive Enterobacteriaceae -infected cases had been resolved after mainly administration of CEPs and fluoroquinolones. The 3rdCEP-resistant E. coli -infected cases were administered fosfomycin (FOM) and doxycycline (DOXY), the 3rdCEP-resistant K. pneumoniae -infected cases were administered DOXY, amikacin (AMK) and faropenem, the 3rdCEP-resistant Citrobacter spp.-infected cases were administered AMK, FOM, and trimethoprim-sulfamethoxazole, the 3rdCEP-resistant P. mirabilis -infected cases were administered chloramphenicol, and the 3rdCEP-resistant Enterobacter spp.-infected cases were administered ofloxacin. Most cases were resolved after administration of these susceptible antimicrobial drugs. , third-generation cephalosporin-resistant, treatment.

[1]  O. Petrini,et al.  Extended-spectrum β-lactamase-producing Enterobacteriaceae in healthy companion animals living in nursing homes and in the community. , 2013, American journal of infection control.

[2]  D. Trott.  β-lactam resistance in gram-negative pathogens isolated from animals. , 2012, Current pharmaceutical design.

[3]  D. Carpenter,et al.  Antimicrobial resistance and pharmacodynamics of canine and feline pathogenic E. coli in the United States. , 2012, Journal of the American Animal Hospital Association.

[4]  L. Wieler,et al.  Extended-spectrum b-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals , and their putative impact on public health : a global perspective , 2012 .

[5]  Y. Nakai,et al.  Mechanisms of resistance to cephalosporin and emergence of O25b‐ST131 clone harboring CTX‐M‐27 β‐lactamase in extraintestinal pathogenic Escherichia coli from dogs and cats in Japan , 2012, Microbiology and immunology.

[6]  J. Wagenaar,et al.  Occurrence and characteristics of extended-spectrum-β-lactamase- and AmpC-producing clinical isolates derived from companion animals and horses. , 2012, The Journal of antimicrobial chemotherapy.

[7]  Y. Nakai,et al.  Prevalence of antimicrobial resistance in relation to virulence genes and phylogenetic origins among urogenital Escherichia coli isolates from dogs and cats in Japan. , 2012, American journal of veterinary research.

[8]  D. Boothe,et al.  In vitro susceptibility of canine and feline Escherichia coli to fosfomycin. , 2011, Veterinary microbiology.

[9]  D. Trott,et al.  Fluoroquinolone resistance mechanisms in multidrug-resistant Escherichia coli isolated from extraintestinal infections in dogs. , 2010, Veterinary microbiology.

[10]  D. Trott,et al.  Identification of Qnr and AAC(6')-1b-cr plasmid-mediated fluoroquinolone resistance determinants in multidrug-resistant Enterobacter spp. isolated from extraintestinal infections in companion animals. , 2010, Veterinary microbiology.

[11]  L. Wieler,et al.  Emergence of human pandemic O25:H4-ST131 CTX-M-15 extended-spectrum-beta-lactamase-producing Escherichia coli among companion animals. , 2010, The Journal of antimicrobial chemotherapy.

[12]  Z. Zeng,et al.  High Prevalence of Plasmid-Mediated Quinolone Resistance Determinants qnr, aac(6′)-Ib-cr, and qepA among Ceftiofur-Resistant Enterobacteriaceae Isolates from Companion and Food-Producing Animals , 2008, Antimicrobial Agents and Chemotherapy.

[13]  J. Morton,et al.  Multidrug-resistant E. coli and enterobacter extraintestinal infection in 37 dogs. , 2008, Journal of veterinary internal medicine.

[14]  D. Trott,et al.  Identification of plasmid-mediated extended-spectrum and AmpC beta-lactamases in Enterobacter spp. isolated from dogs. , 2007, Journal of medical microbiology.

[15]  L. Wieler,et al.  Companion animals: a relevant source of extended-spectrum β-lactamase-producing fluoroquinolone-resistant Citrobacter freundii. , 2011, International journal of antimicrobial agents.