Expression of leucocyte adhesion molecules at the human blood‐brain barrier (BBB)

The expression of leucocyte adhesion molecules was studied on cerebral endothelia by immunocytochemistry. In peritumoral “normal” brain tissue we found low endothelial expression of 1CAMI, LFA3, CD44, and CD9, whereas VLA1 was present on vessels in high incidence and density. LFAl, CD2, and CR3 were found on intraluminal and parenchymal leucocytes, but were absent on brain vessels. In brain tumors and inflammatory brain lesions, we observed an up‐regulation of endothelial ICAM1 and LFA3 expression, whereas other adhesion molecules on endothelial cells remained unchanged.

[1]  M. Ascher,et al.  AIDS and programmed cell death. , 1991, Immunology today (Amsterdam. Regular ed.).

[2]  W. Hickey,et al.  T‐lymphocyte entry into the central nervous system , 1991, Journal of neuroscience research.

[3]  G. Pryce,et al.  Comparison of the immunological properties of rat cerebral and aortic endothelium , 1990, Journal of Neuroimmunology.

[4]  R. Rothlein,et al.  Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis , 1990, Journal of Neuroimmunology.

[5]  A. Cross,et al.  Adhesion molecules on endothelial cells in the central nervous system: an emerging area in the neuroimmunology of multiple sclerosis. , 1990, Clinical immunology and immunopathology.

[6]  A. Cross,et al.  Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system , 1990, The Journal of experimental medicine.

[7]  R. Sobel,et al.  Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. , 1990, The American journal of pathology.

[8]  M. Thornhill,et al.  IL-4 increases human endothelial cell adhesiveness for T cells but not for neutrophils. , 1990, Journal of immunology.

[9]  P. Lantos,et al.  Lymphocyte migration into brain modelled in vitro: control by lymphocyte activation, cytokines, and antigen. , 1990, Cellular immunology.

[10]  G. Rice,et al.  Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism , 1990, The Journal of experimental medicine.

[11]  J. Slupsky,et al.  Anti-CD9 monoclonal antibodies induce homotypic adhesion of pre-B cell lines by a novel mechanism. , 1990, Journal of immunology.

[12]  B. Haynes,et al.  Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation. , 1990, Journal of immunology.

[13]  A. Cross,et al.  Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. , 1990, Laboratory investigation; a journal of technical methods and pathology.

[14]  R. Tizard,et al.  Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes , 1989, Cell.

[15]  M. Sanders,et al.  The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition. , 1989, Immunology today.

[16]  M. Telen,et al.  CD44--a molecule involved in leukocyte adherence and T-cell activation. , 1989, Immunology today.

[17]  E. Berg,et al.  Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes. Role of homing receptors and other adhesion molecules. , 1989, Transplantation.

[18]  L. Wahl,et al.  Dual role of the CD44 molecule in T cell adhesion and activation. , 1989, Journal of immunology.

[19]  C. Figdor,et al.  IL-4 induces LFA-1 and LFA-3 expression on Burkitt's lymphoma cell lines. Requirement of additional activation by phorbol myristate acetate for induction of homotypic cell adhesions. , 1989, Journal of immunology.

[20]  B. Caillou,et al.  CD44 contributes to T cell activation. , 1989, Journal of immunology.

[21]  L. Picker,et al.  Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types , 1989, The Journal of cell biology.

[22]  P. Eikelenboom,et al.  Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family , 1989, Neuroscience Letters.

[23]  Michael Loran Dustin,et al.  The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation , 1989, Journal of Neuroimmunology.

[24]  A. Daar,et al.  Chemical composition and tissue distribution of the human CDw44 glycoprotein. , 1989, Immunology.

[25]  H. Lassmann,et al.  Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat , 1989, Neuroscience Letters.

[26]  L. Stoolman.  Adhesion molecules controlling lymphocyte migration , 1989, Cell.

[27]  C. Jacob.  Cytokines and anti-cytokines. , 1989, Current opinion in immunology.

[28]  F. Sánchez‐Madrid,et al.  Triggering of co-mitogenic signals in T cell proliferation by anti-LFA-1 (CD18, CD11a), LFA-3, and CD7 monoclonal antibodies. , 1988, Journal of immunology.

[29]  Michael Loran Dustin,et al.  Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells , 1988, The Journal of cell biology.

[30]  D. Paterson,et al.  Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies , 1988, The Journal of experimental medicine.

[31]  Timothy A. Springer,et al.  Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1) , 1987, Cell.

[32]  R. Cotran,et al.  Identification of an inducible endothelial-leukocyte adhesion molecule. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Y. Saegusa,et al.  Stimulation of endothelial cell binding of lymphocytes by tumor necrosis factor. , 1987, Journal of immunology.

[34]  R. Pardi,et al.  Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells. , 1987, The Journal of clinical investigation.

[35]  Richard O. Hynes,et al.  Integrins: A family of cell surface receptors , 1987, Cell.

[36]  K. Frei,et al.  Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells , 1987 .

[37]  Michael Loran Dustin,et al.  The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. , 1987, Annual review of immunology.

[38]  T. Springer,et al.  T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies. , 1986, Journal of immunology.

[39]  R. Atkins,et al.  Identification of a major sialoprotein in the glycocalyx of human visceral glomerular epithelial cells. , 1986, The Journal of clinical investigation.

[40]  T. Springer,et al.  Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones , 1986, Nature.

[41]  W. Fiers,et al.  Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. , 1986, Journal of immunology.

[42]  Michael Loran Dustin,et al.  A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. , 1986, Journal of immunology.

[43]  Michael Loran Dustin,et al.  Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). , 1986, Journal of immunology.

[44]  E. Butcher,et al.  The regulation of lymphocyte traffic. , 1986, Current topics in microbiology and immunology.

[45]  W. Griffin,et al.  Functional capacity of solid tissue transplants in the brain: evidence for immunological privilege , 1985, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[46]  H. Wekerle,et al.  T-LINE MEDIATED EAE - A MORPHOLOGICAL STUDY OF DEVELOPING LESIONS , 1985 .

[47]  D. Ruiter,et al.  Monoclonal antibody PAL-E specific for endothelium. , 1985, Laboratory investigation; a journal of technical methods and pathology.

[48]  W. Fiers,et al.  Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules. , 1984, Journal of immunology.

[49]  E. Reinherz,et al.  Immunohistochemical staining of human brain with monoclonal antibodies that identify lymphocytes, monocytes, and the Ia antigen , 1983, Journal of Neuroimmunology.

[50]  G. Goldstein,et al.  Recent advances in understanding brain capillary function , 1983, Annals of neurology.

[51]  F. Sánchez‐Madrid,et al.  The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. , 1983, Journal of immunology.

[52]  A. Fontana,et al.  Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. , 1982, Journal of immunology.

[53]  M. Greaves,et al.  P-24: a human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody , 1981, The Journal of experimental medicine.

[54]  J. Fabre,et al.  Monoclonal antibody to a human brain‐granulocyte‐T lymphocyte antigen probably homologous to the W 3/13 antigen of the rat , 1980, European journal of immunology.

[55]  D. Bigner,et al.  Immunobiologic aspects of the brain and human gliomas. A review. , 1980, The American journal of pathology.

[56]  C. Barker,et al.  Immunologically privileged sites. , 1977, Advances in immunology.