Pregnancy after valproate withdrawal—Fetal malformations and seizure control

To assess the outcomes in women with epilepsy in relation to fetal malformation and epileptic seizure control during pregnancy when valproate (VPA) intake was ceased, or the drug's dose was reduced before pregnancy.

[1]  M. Manfredi,et al.  Doing without valproate in women of childbearing potential with idiopathic generalized epilepsy: Implications on seizure outcome , 2019, Epilepsia.

[2]  T. Tomson,et al.  Declining malformation rates with changed antiepileptic drug prescribing , 2019, Neurology.

[3]  G. Koren,et al.  Dose-Dependent Risk of Malformations With Antiepileptic Drugs: An Analysis of Data From the EURAP Epilepsy and Pregnancy Registry , 2015, Therapeutic drug monitoring.

[4]  T. O'Brien,et al.  Valproate still has a place in women with epilepsy , 2015, Epilepsia.

[5]  K. Meador,et al.  IQ at 6 years after in utero exposure to antiepileptic drugs , 2015, Neurology.

[6]  T. O'Brien,et al.  Dose dependence of fetal malformations associated with valproate , 2013, Neurology.

[7]  T. Tomson,et al.  Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry , 2011, The Lancet Neurology.

[8]  T. O'Brien,et al.  Changing patterns of antiepileptic drug use in pregnant Australian women , 2010, Acta neurologica Scandinavica.

[9]  M. Eadie,et al.  Seizure control in antiepileptic drug‐treated pregnancy , 2008, Epilepsia.

[10]  M. Eadie,et al.  The Australian antiepileptic drug in pregnancy register: Aspects of data collection and analysis , 2007, Journal of Clinical Neuroscience.

[11]  T. O'Brien,et al.  Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy , 2004, Journal of clinical neuroscience.

[12]  M. Riley,et al.  Birth Defects in Victoria 1983–1998 , 2000 .

[13]  K. Inanaga,et al.  Multi‐institutional Study on the Teratogenicity and Fetal Toxicity of Antiepileptic Drugs: A Report of a Collaborative Study Group in Japan , 1980, Epilepsia.