Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility

[1]  W. Birchmeier,et al.  Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. , 1998, Science.

[2]  Anthony E. Reeve,et al.  E-cadherin germline mutations in familial gastric cancer , 1998, Nature.

[3]  Akira Kikuchi,et al.  Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin , 1998 .

[4]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[5]  W. Birchmeier,et al.  Role of morphogenetic factors in metastasis of mammary carcinoma cells , 1998, Oncogene.

[6]  M. Ikura,et al.  Lateral self‐assembly of E‐cadherin directed by cooperative calcium binding , 1997, FEBS letters.

[7]  A. Hall,et al.  The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts , 1997, The Journal of cell biology.

[8]  S. Nishizuka,et al.  Inactivation of the E‐Cadherin Gene in Primary Gastric Carcinomas and Gastric Carcinoma Cell Lines , 1996, Japanese journal of cancer research : Gann.

[9]  B. Herrmann,et al.  Nuclear localization of β-catenin by interaction with transcription factor LEF-1 , 1996, Mechanisms of Development.

[10]  Michael Kühl,et al.  Functional interaction of β-catenin with the transcription factor LEF-1 , 1996, Nature.

[11]  Hans Clevers,et al.  XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos , 1996, Cell.

[12]  S. Hirohashi,et al.  E‐Cadherin Gene Mutations in Signet Ring Cell Carcinoma of the Stomach , 1996, Japanese journal of cancer research : Gann.

[13]  W. Birchmeier,et al.  Prognostic value of E‐cadherin expression in 413 gastric carcinomas , 1996, International journal of cancer.

[14]  M. Ikura,et al.  Structural basis of calcium-induced E-cadherin rigidification and dimerization , 1996, Nature.

[15]  T. Mitchison,et al.  Actin-Based Cell Motility and Cell Locomotion , 1996, Cell.

[16]  D. Lauffenburger,et al.  Cell Migration: A Physically Integrated Molecular Process , 1996, Cell.

[17]  A. Ochiai,et al.  Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse-type gastric cancer. , 1996, Cancer letters.

[18]  S. Zigmond,et al.  Signal transduction and actin filament organization. , 1996, Current opinion in cell biology.

[19]  A. Watanabe,et al.  Clinicopathologic evaluation of immunohistochemical E‐cadherin expression in human gastric carcinomas , 1995, Cancer.

[20]  J. Gordon,et al.  Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin , 1995, Science.

[21]  D L Rimm,et al.  Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[22]  A. P. Soler,et al.  Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin , 1995, The Journal of cell biology.

[23]  F. Molemans,et al.  Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). , 1995, Genomics.

[24]  M. Ikura,et al.  Solution structure of the epithelial cadherin domain responsible for selective cell adhesion , 1995, Science.

[25]  W. Birchmeier,et al.  E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton , 1994, The Journal of cell biology.

[26]  N. Lemoine,et al.  Loss of membranous E‐cadherin expression in pancreatic cancer: Correlation with lymph node metastasis, high grade, and advanced stage , 1994, The Journal of pathology.

[27]  S. Hirohashi,et al.  Point Mutation of the E–Cadherin Gene in Invasive Lobular Carcinoma of the Breast , 1994, Japanese journal of cancer research : Gann.

[28]  S. Ishihara,et al.  The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules , 1994, The Journal of cell biology.

[29]  J. Engel,et al.  Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding. , 1994, European journal of biochemistry.

[30]  H. Höfler,et al.  E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. , 1994, Cancer research.

[31]  W J Nelson,et al.  Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells , 1994, The Journal of cell biology.

[32]  W. Birchmeier,et al.  Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. , 1994, Biochimica et biophysica acta.

[33]  A. Berchuck,et al.  Mutations of the E–cadherin gene in human gynecologic cancers , 1994, Nature Genetics.

[34]  S. Hirohashi,et al.  Frequent Loss of α Catenin Expression in Scirrhous Carcinomas with Scattered Cell Growth , 1994, Japanese journal of cancer research : Gann.

[35]  S. Hirohashi,et al.  E-cadherin gene mutations in human gastric carcinoma cell lines. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[36]  F. Masiarz,et al.  Association of the APC gene product with beta-catenin. , 1993, Science.

[37]  K. Kinzler,et al.  Association of the APC tumor suppressor protein with catenins. , 1993, Science.

[38]  M. Takeichi Cadherins in cancer: implications for invasion and metastasis. , 1993, Current opinion in cell biology.

[39]  R. Kemler From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. , 1993, Trends in genetics : TIG.

[40]  H. Höfler,et al.  Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. , 1993, Human molecular genetics.

[41]  W. Birchmeier,et al.  E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. , 1993, Cancer research.

[42]  B. Vogelstein,et al.  Cell adhesion molecules as tumour suppressors. , 1993, Trends in cell biology.

[43]  W. Birchmeier,et al.  A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[44]  C. Kintner Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain , 1992, Cell.

[45]  Kathleen A. Krzeminski,et al.  Remodeling the cell surface distribution of membrane proteins during the development of epithelial cell polarity , 1992, The Journal of cell biology.

[46]  M. Quintanilla,et al.  A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis , 1991, The Journal of cell biology.

[47]  W. Birchmeier,et al.  E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells , 1991, The Journal of cell biology.

[48]  B. Zetter,et al.  In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. , 1991, Science.

[49]  M. Takeichi,et al.  Cadherin cell adhesion receptors as a morphogenetic regulator. , 1991, Science.

[50]  J. Engel,et al.  Single amino acid substitutions in one Ca2+ binding site of uvomorulin abolish the adhesive function , 1990, Cell.

[51]  R. Kemler,et al.  Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin , 1990, The Journal of cell biology.

[52]  M. Ringwald,et al.  Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[53]  L. Romer,et al.  EndoCAM: a novel endothelial cell-cell adhesion molecule , 1990, The Journal of cell biology.

[54]  J. Thiery,et al.  Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells , 1989, The Journal of cell biology.

[55]  M. Takeichi,et al.  Cell binding function of E‐cadherin is regulated by the cytoplasmic domain. , 1988, The EMBO journal.

[56]  Akinao Nose,et al.  Expressed recombinant cadherins mediate cell sorting in model systems , 1988, Cell.

[57]  K. Yasuda,et al.  Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA , 1987, Nature.

[58]  G. Edelman,et al.  Linear organization of the liver cell adhesion molecule L-CAM. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[59]  P. Laurén,et al.  THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. , 1965, Acta pathologica et microbiologica Scandinavica.

[60]  H. Barr,et al.  Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasia-adenocarcinoma sequence: correlation with disease progression and dedifferentiation. , 1998, The American journal of pathology.

[61]  H. Höfler,et al.  No Evidence for Mutations in the α- and β-Catenin Genes in Human Gastric and Breast Carcinomas , 1996 .

[62]  E. Hay An overview of epithelio-mesenchymal transformation. , 1995, Acta anatomica.

[63]  M. Takeichi,et al.  Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin. , 1993, Molecular biology of the cell.

[64]  W. Birchmeier,et al.  The role of E-cadherin and scatter factor in tumor invasion and cell motility. , 1991, EXS.

[65]  A. Murray,et al.  In situ embedding of cell monolayers cultured on plastic surfaces for electron microscopy. , 1991, Biotechnic & histochemistry : official publication of the Biological Stain Commission.