Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.

[1]  J. Sullivan,et al.  Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. , 2015, Journal of medicinal chemistry.

[2]  Brian J. Smith,et al.  N‐terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage‐gated potassium channel Kv1.3 , 2015, The FEBS journal.

[3]  C. Domene,et al.  In silico identification of PAP-1 binding sites in the Kv1.2 potassium channel. , 2015, Molecular pharmaceutics.

[4]  W. Ho,et al.  Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015. , 2015, Journal of natural products.

[5]  J. Dolly,et al.  Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels. , 2015, Chemical communications.

[6]  R. Norton,et al.  Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK , 2015, Marine drugs.

[7]  H. Katus,et al.  Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action , 2014, Drug design, development and therapy.

[8]  J. Yli-Kauhaluoma,et al.  Exploring Marine Resources for Bioactive Compounds , 2014, Planta Medica.

[9]  J. Ilaš,et al.  A convenient strategy for synthesizing the Agelas alkaloids clathrodin, oroidin, and hymenidin and their (un)saturated linker analogs , 2014 .

[10]  D. Madge,et al.  Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels , 2014, Marine drugs.

[11]  Danijel Kikelj,et al.  Antimicrobial Activity of the Marine Alkaloids, Clathrodin and Oroidin, and Their Synthetic Analogues , 2014, Marine drugs.

[12]  D. Madge,et al.  Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges. , 2013, European journal of medicinal chemistry.

[13]  H. Katus,et al.  Inhibition of cardiac Kv1.5 and Kv4.3 potassium channels by the class Ia anti-arrhythmic ajmaline: mode of action , 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

[14]  C. Vale,et al.  Differential effects of crambescins and crambescidin 816 in voltage-gated sodium, potassium and calcium channels in neurons. , 2013, Chemical research in toxicology.

[15]  Wiktor Jurkowski,et al.  Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2(3) by High-Throughput Virtual Screening and Automated Patch Clamp , 2012, ChemMedChem.

[16]  S. Long,et al.  Crystal Structure of the Human Two–Pore Domain Potassium Channel K2P1 , 2012, Science.

[17]  Neil A Castle,et al.  Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy , 2010, Expert opinion on therapeutic patents.

[18]  Jianpeng Ma,et al.  Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement , 2010, Proceedings of the National Academy of Sciences.

[19]  Heike Wulff,et al.  Voltage-gated potassium channels as therapeutic targets , 2009, Nature Reviews Drug Discovery.

[20]  K. Chandy,et al.  The functional network of ion channels in T lymphocytes , 2009, Immunological reviews.

[21]  J. Tamargo,et al.  IKur/Kv1.5 channel blockers for the treatment of atrial fibrillation , 2009 .

[22]  Heike Wulff,et al.  International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels , 2005, Pharmacological Reviews.

[23]  H. Wulff,et al.  Design of PAP-1, a Selective Small Molecule Kv1.3 Blocker, for the Suppression of Effector Memory T Cells in Autoimmune Diseases , 2005, Molecular Pharmacology.

[24]  E. Campbell,et al.  Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling , 2005, Science.

[25]  G. Yellen.  The voltage-gated potassium channels and their relatives , 2002, Nature.

[26]  Lindel,et al.  Synthesis of the marine natural product oroidin and its Z-isomer , 2000, The Journal of organic chemistry.

[27]  O. McManus,et al.  Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels. , 1999, Cellular immunology.

[28]  V. Uebele,et al.  Functional Differences in Kv1.5 Currents Expressed in Mammalian Cell Lines Are Due to the Presence of Endogenous Kvβ2.1 Subunits (*) , 1996, The Journal of Biological Chemistry.

[29]  A. Rodríguez,et al.  Effect of alkaloid toxins from tropical marine sponges on membrane sodium currents. , 1995, Toxicon : official journal of the International Society on Toxinology.

[30]  J. Tytgat,et al.  Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs , 1992, Neuron.