Exposure to sibutramine during pregnancy.

QUESTION One of my patients who was taking sibutramine to lose weight found out that she had unexpectedly conceived. The medication was stopped as soon as she found out, about 5 weeks into the pregnancy. Is the baby at risk? Should the pregnancy be aborted? ANSWER No data to date suggest that involuntary exposure to sibutramine during pregnancy carries major risk of congenital malformations. Nevertheless, this medication should be avoided whenever possible during pregnancy, as there is little information on its effects.

[1]  L. Khaodhiar,et al.  Pharmacological and surgical treatments for obesity. , 2006, American heart journal.

[2]  G. Koren,et al.  Exposure to sibutramine during pregnancy: a case series. , 2004, European journal of obstetrics, gynecology, and reproductive biology.

[3]  F. Yaris,et al.  Sibutramine use in pregnancy: report of two cases. , 2004, Birth defects research. Part A, Clinical and molecular teratology.

[4]  A. Wirth,et al.  Long-term weight loss with sibutramine: a randomized controlled trial. , 2001, JAMA.

[5]  A. Astrup,et al.  Effect of sibutramine on weight maintenance after weight loss: a randomised trial , 2000, The Lancet.

[6]  G. Fanghänel,et al.  A clinical trial of the use of Sibutramine for the treatment of patients suffering essential obesity , 2000, International Journal of Obesity.

[7]  G. Shaw,et al.  Neural tube defects and maternal weight reduction in early pregnancy. , 1994, Reproductive toxicology.

[8]  A. Cavaliere,et al.  Early First-Trimester Sibutramine Exposure , 2006, Drug safety.