论文信息 - Reversal of Minimum Alveolar Concentrations of Volatile Anesthetics by Chromosomal Substitution

Reversal of Minimum Alveolar Concentrations of Volatile Anesthetics by Chromosomal Substitution

GENETIC susceptibility to pharmacological agents, termed “pharmacogenomics,” is an emerging field focused on genetic differences underlying alterations of physiologic responses to pharmacological agents. The objective of this study was to systematically compare differences in the minimum alveolar concentration (MAC) (defined as a movement response to a noxious sensory stimulus by volatile anesthetics) in two genotypically distinct parental strains of rats (Dahl Salt Sensitive [SS] and control Brown Norway [BN]) and in two consomic (chromosomal transfer) strains (SS.BN.13 and SS.BN.16). The latter were two strains available from a larger panel of consomics in which single chromosomes from the BN strain have been introgressed into an otherwise unchanged SS genetic background. The underlying hypothesis of this study is that SS animals have a greater overall sensitivity to the action of volatile anesthetics that is attributable to specific pharmacogenomic mechanisms related to one or several chromosomes.

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