p57kip2 is useful in the classification and differential diagnosis of complete and partial hydatidiform moles

Aims:  To determine the utility of p57kip2 in the diagnosis of hydatidiform mole. p57kip2 protein is a cyclin‐dependent kinase inhibitor (CDKI) and is strongly paternally imprinted, being expressed from the maternal allele. It has been hypothesized that complete mole (CHM) with only the paternal genome would display reduced or nearly absent expression of p57kip2 compared to partial mole (PHM) having both paternal and maternal genomes.

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