Scenarios on the future of biotechnology

Abstract The major areas of research and development in biotechnology are maturing at a rapid rate, and may soon converge with one another. These emerging biotechnology areas range from the development of new medicines and drugs, genetically engineered foods, biologically controlled industrial manufacturing processes, and biologically based computing devices to the creation of new industrial materials and devices based upon biological structures and the use of biotechnology in food production. Each of these research areas carries the potential for strong societal reaction. To explore the potential impact of biotechnology on society, two fundamental drivers that influence societal acceptance of biotechnology are described. First, the extent to which technological integration proceeds may strongly impact the way society uses and perceives biotechnology. Second, the degree to which the public eventually accepts biotechnologically derived products and processes as legitimate and reliable alternatives to current products may shape both market demand and public policy. Taken together, these drivers suggest four discrete alternative scenarios for the future of biotechnology. Implications of these scenarios are discussed.

[1]  S. Delagrave,et al.  Novel approaches for discovering industrial enzymes. , 1999, Current opinion in microbiology.

[2]  E. Krebbers,et al.  Gene discovery and product development for grain quality traits. , 1999, Science.

[3]  W Tvaruskó,et al.  Time-resolved analysis and visualization of dynamic processes in living cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[4]  The emerging role of the genomics revolution in agricultural biotechnology , 1998, Nature Biotechnology.

[5]  W. Blackstock,et al.  Proteomics: quantitative and physical mapping of cellular proteins. , 1999, Trends in biotechnology.

[6]  G. Shenfield Therapeutic drug monitoring beyond 2000. , 1998, British journal of clinical pharmacology.

[7]  P. Rathjen,et al.  Properties and uses of embryonic stem cells: prospects for application to human biology and gene therapy. , 1998, Reproduction, fertility, and development.

[8]  Himmel,et al.  Cellulase for commodity products from cellulosic biomass , 1999, Current opinion in biotechnology.

[9]  L M Adleman,et al.  Molecular computation of solutions to combinatorial problems. , 1994, Science.

[10]  W. Stemmer DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[11]  S. Macnaughton,et al.  Developments in terrestrial bacterial remediation of metals. , 1999, Current opinion in biotechnology.

[12]  H. Berg,et al.  Powering the flagellar motor of Escherichia coli with an external voltage source , 1995, Nature.

[13]  S. Chang Planetary environments and the origin of life. , 1999, The Biological bulletin.

[14]  S. Mann The biomimetics of enamel: a paradigm for organized biomaterials synthesis. , 1997, Ciba Foundation symposium.

[15]  Briggs,et al.  Engineering new plant strains for commercial markets , 1998, Current opinion in biotechnology.

[16]  Carlo C. Maley,et al.  DNA Computation: Theory, Practice, and Prospects , 1998, Evolutionary Computation.

[17]  E. Braun,et al.  DNA-templated assembly and electrode attachment of a conducting silver wire , 1998, Nature.

[18]  David Michael Hertz The tuning of the word : the musico-literary poetics of the symbolist movement , 1987 .

[19]  C. Schmidt-Dannert,et al.  Directed evolution of industrial enzymes. , 1999, Trends in biotechnology.

[20]  P. James,et al.  Of genomes and proteomes. , 1997, Biochemical and biophysical research communications.

[21]  Charles A Vacanti,et al.  Tissue engineering: The first decade and beyond , 1998, Journal of cellular biochemistry.

[22]  David J. Stevenson,et al.  Life-sustaining planets in interstellar space? , 1999, Nature.

[23]  Dusting off panspermia , 1996, Nature.

[24]  Yan P. Yuan,et al.  Predicting function: from genes to genomes and back. , 1998, Journal of molecular biology.

[25]  J. Brockmöller Pharmacogenomics--science fiction come true. , 1999, International journal of clinical pharmacology and therapeutics.

[26]  L. Loeb,et al.  Creating novel enzymes by applied molecular evolution. , 1997, Chemistry & biology.

[27]  R. Llinás,et al.  Human oscillatory brain activity near 40 Hz coexists with cognitive temporal binding. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[28]  J C Cox,et al.  The complexities of DNA computation. , 1999, Trends in biotechnology.

[29]  A. Trounson,et al.  Potential benefits of cell cloning for human medicine. , 1998, Reproduction, fertility, and development.

[30]  G. Gadd,et al.  An integrated microbial process for the bioremediation of soil contaminated with toxic metals , 1998, Nature Biotechnology.