Microwave dielectric spectroscopy: An emerging analyzing technique for biological investigations at the cellular level

This paper presents a current status of microwave dielectric spectroscopy at the cellular level for biological investigations. The convergence of microfluidic and microwave microtechnologies enables indeed the development of an innovative observation technique of the living at the micro-scale. The non-invasive and label free detection of living or dead cells in their culture medium without any contact, the possible identification of the bio-elements and the real time monitoring ability of the technique constitute major features, which are suitable for early diseases diagnostic, preliminary and personalized drugs evaluation, toward a better patient healthcare.

[1]  S S Stuchly,et al.  Microwave coplanar sensors for dielectric measurements , 1998 .

[2]  Charles Polk,et al.  CRC Handbook of Biological Effects of Electromagnetic Fields , 1986 .

[3]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[4]  T. Fujii,et al.  Integrated Broadband Microwave and Microfluidic Sensor Dedicated to Bioengineering , 2009, IEEE Transactions on Microwave Theory and Techniques.

[5]  David Dubuc,et al.  Microwave signatures of alive B-lymphoma cells suspensions , 2011, 2011 IEEE Topical Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems.

[6]  M. R. Freeman,et al.  A microwave interferometric system for simultaneous actuation and detection of single biological cells. , 2009, Lab on a chip.

[7]  Lydia L. Sohn,et al.  Dielectric spectroscopy for bioanalysis: From 40 Hz to 26.5 GHz in a microfabricated wave guide , 2001 .

[8]  Geoffrey G. Eichholz,et al.  RF/Microwave Interaction with Biological Tissues , 2006 .

[9]  Dimitris Pavlidis,et al.  High frequency wideband permittivity measurements of biological substances using coplanar waveguides and application to cell suspensions , 2008, 2008 IEEE MTT-S International Microwave Symposium Digest.

[10]  F. Barnes,et al.  Handbook of biological effects of electromagnetic fields , 2007 .

[11]  David Djajaputra,et al.  RF / Microwave Interaction with Biological Tissues , 2006 .

[12]  M. Samet,et al.  Parametric study on the dielectric properties of biological tissues , 2015, 2015 16th International Conference on Sciences and Techniques of Automatic Control and Computer Engineering (STA).

[13]  Molly M. Stevens,et al.  Microwave Debye relaxation analysis of dissolved proteins: Towards free-solution biosensing , 2011 .

[14]  H. Fricke,et al.  THE ELECTRIC RESISTANCE AND CAPACITY OF BLOOD FOR FREQUENCIES BETWEEN 800 AND 4½ MILLION CYCLES , 1925, The Journal of general physiology.

[15]  J. Fournié,et al.  Broadband discrimination of living and dead lymphoma cells with a microwave interdigitated capacitor , 2013, 2013 IEEE Topical Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems.

[16]  Yang Yang,et al.  Distinguishing the viability of a single yeast cell with an ultra-sensitive radio frequency sensor. , 2010, Lab on a chip.

[17]  J.C. Booth,et al.  Broadband Permittivity Measurements of Liquid and Biological Samples using Microfluidic Channels , 2006, 2006 IEEE MTT-S International Microwave Symposium Digest.

[18]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[19]  André Vander Vorst,et al.  RF/Microwave Interaction with Biological Tissues: Vander Vorst/RF/Microwave Interaction with Biological Tissues , 2005 .

[20]  K. Cole,et al.  Dispersion and Absorption in Dielectrics I. Alternating Current Characteristics , 1941 .

[21]  D. Dubuc,et al.  Accurate Nanoliter Liquid Characterization Up to 40 GHz for Biomedical Applications: Toward Noninvasive Living Cells Monitoring , 2012, IEEE Transactions on Microwave Theory and Techniques.

[22]  H. P. Schwan,et al.  Electrical properties of blood and its constitutents: Alternating current spectroscopy , 1983, Blut: Zeitschrift für die Gesamte Blutforschung.