Arsenic, GSTO2 Asp142 polymorphism, health and treatment

Arsenic is a natural metallic element found in low concentrations in virtually every part of the environment, including waters and foods. The ingestion of arsenic by humans can cause a variety of disorders. Glutathione S-transferase omega (GSTO) is a member of phase II xenobiotic metabolizing enzymes. GSTO2 (a member of GST omega) participates in detoxification of inorganic arsenic. In human, the A>G transition at nucleotide position 424 of GSTO2 was reported. This variation causes an Asn142Asp substitution. The Asp142 allozyme was expressed at approximately 80 % of the level of Asn142 allozyme. It is hypothesized that the GSTO2 polymorphism may alter the risk of several diseases which are related to chronic arsenic poisoning. On the other hand, because arsenic trioxide is used for treatment of acute promyelocytic leukemia; it is possible that Asn142 allozyme may decrease the therapeutic effect(s) of the drug.

[1]  M. Saadat,et al.  Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer , 2009, Molecular Biology Reports.

[2]  Mazumder Dn.  Effect of drinking arsenic contaminated water in children. , 2007, Indian pediatrics.

[3]  L. Ward,et al.  Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma. , 2007, Revista medica de Chile.

[4]  B. Ritz,et al.  Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease , 2007, Neuroscience Letters.

[5]  F. Jones.  A broad view of arsenic. , 2007, Poultry science.

[6]  T. Rohan,et al.  Trace elements and cancer risk: a review of the epidemiologic evidence , 2007, Cancer Causes & Control.

[7]  Prosun Bhattacharya,et al.  Human Health Effects From Chronic Arsenic Poisoning–A Review , 2006, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[8]  D. Schaid,et al.  GLUTATHIONE S-TRANSFERASE OMEGA 1 AND OMEGA 2 PHARMACOGENOMICS , 2006, Drug Metabolism and Disposition.

[9]  N. Bufalo,et al.  Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients , 2006, Journal of Cancer Research and Clinical Oncology.

[10]  S. Wongkham,et al.  Polymorphism of glutathione S-transferase omega gene and risk of cancer. , 2006, Cancer letters.

[11]  S. Petmitr,et al.  Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer. , 2006, Journal of experimental & clinical cancer research : CR.

[12]  A. Sharrett,et al.  Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence. , 2005, American journal of epidemiology.

[13]  C. Ji,et al.  Cloning, expression and characterization of human glutathione S-transferase Omega 2. , 2005, International journal of molecular medicine.

[14]  V. Vasiliou,et al.  Analysis of the glutathione S-transferase (GST) gene family , 2004, Human Genomics.

[15]  A. Natarajan,et al.  Chromosomal aberrations in arsenic-exposed human populations: a review with special reference to a comprehensive study in West Bengal, India , 2004, Cytogenetic and Genome Research.

[16]  Richard B. Hayes,et al.  The carcinogenicity of metals in humans , 1997, Cancer Causes & Control.

[17]  B. Walsh,et al.  Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles. , 2003, Chemical research in toxicology.

[18]  G. Sutherland,et al.  Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. , 2003, Pharmacogenetics.

[19]  D. Sheehan,et al.  Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. , 2001, The Biochemical journal.

[20]  D. Liebler,et al.  Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. , 2001, Chemical research in toxicology.

[21]  Zhen-yi Wang.  Arsenic compounds as anticancer agents , 2001, Cancer Chemotherapy and Pharmacology.

[22]  Ning-Li Li,et al.  A study on arsenic trioxide inducing in vitro apoptosis of gastric cancer cell lines. , 2000, World journal of gastroenterology.

[23]  M. Vahter.  Genetic polymorphism in the biotransformation of inorganic arsenic and its role in toxicity. , 2000, Toxicology letters.

[24]  Y. Akao,et al.  Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro , 1999, FEBS letters.

[25]  M. Parker,et al.  Structure and function of glutathione S-transferases. , 1994, Biochimica et biophysica acta.