Antibiotic Consumption and Stewardship at a Hospital outside of an Early Coronavirus Disease 2019 Epicenter

There are scant data on the impact of coronavirus disease 2019 (COVID-19) on hospital antibiotic consumption, and no data from outside epicenters. At our nonepicenter hospital, antibiotic days of therapy (DOT) and bed days of care (BDOC) were reduced by 151.5/month and 285/month, respectively, for March to June 2020 compared to 2018–2019 (P = 0.001 and P < 0.001). DOT per 1,000 BDOC was increased (8.1/month; P = 0. ABSTRACT There are scant data on the impact of coronavirus disease 2019 (COVID-19) on hospital antibiotic consumption, and no data from outside epicenters. At our nonepicenter hospital, antibiotic days of therapy (DOT) and bed days of care (BDOC) were reduced by 151.5/month and 285/month, respectively, for March to June 2020 compared to 2018–2019 (P = 0.001 and P < 0.001). DOT per 1,000 BDOC was increased (8.1/month; P = 0.001). COVID-19 will impact antibiotic consumption, stewardship, and resistance in ways that will likely differ temporally and by region.

[1]  M. Pujol,et al.  Antibiotic prescription during the COVID-19 pandemic: A biphasic pattern , 2020, Infection Control & Hospital Epidemiology.

[2]  G. Bearman,et al.  Impact of COVID-19 on pneumonia-focused antibiotic use at an academic medical center , 2020, Infection Control & Hospital Epidemiology.

[3]  D. MacFadden,et al.  Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis , 2020, Clinical Microbiology and Infection.

[4]  C. Clancy,et al.  PRO: The COVID-19 pandemic will result in increased antimicrobial resistance rates , 2020, JAC-antimicrobial resistance.

[5]  P. Collignon,et al.  CON: COVID-19 will not result in increased antimicrobial resistance prevalence , 2020, JAC-antimicrobial resistance.

[6]  I. Jordan,et al.  Pediatric antimicrobial stewardship in the COVID-19 outbreak , 2020, Infection Control & Hospital Epidemiology.

[7]  M. Vaduganathan,et al.  Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the United States. , 2020, JAMA.

[8]  C. Clancy,et al.  COVID-19, superinfections and antimicrobial development: What can we expect? , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.