Update on Tumor Cell Procoagulant Factors

Tumor cells produce tissue factor, cancer procoagulant, plasminogen activators and other factors that interact with the coagulation system, the fibrinolytic system and vascular or blood cells such that they can upset the normal homeostasis and balance between activation and inhibition of the coagulation and fibrinolytic systems. These activities play a role in tumor cell growth and metastasis, vascular wall function, and hemostasis. Proteases and their inhibitors are intimately involved in all aspects of the hemostatic, cell proliferation and cellular signalling systems. This review provides a brief examination of recent observations in this complex interaction of cellular and hemostatic factors.

[1]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[2]  S. Nakamura,et al.  Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration , 2000, British Journal of Cancer.

[3]  N. Mackman,et al.  Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domain. , 2000, The Journal of clinical investigation.

[4]  Arkel Ys.  Thrombosis and cancer. , 2000 .

[5]  U. Pendurthi,et al.  Factor VIIa and Thrombin Induce the Expression of Cyr61 and Connective Tissue Growth Factor, Extracellular Matrix Signaling Proteins That Could Act as Possible Downstream Mediators in Factor VIIa·Tissue Factor-induced Signal Transduction* , 2000, The Journal of Biological Chemistry.

[6]  S. Coughlin,et al.  Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Herbert,et al.  Vascular endothelial growth factor production by fibroblasts in response to factor VIIa binding to tissue factor involves thrombin and factor Xa. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[8]  H. Prydz,et al.  Binding of Factor VIIa to Tissue Factor on Keratinocytes Induces Gene Expression* , 2000, The Journal of Biological Chemistry.

[9]  W. Kisiel,et al.  Expression of prothrombin fragment 1+2 in cancer tissue as an indicator of local activation of blood coagulation. , 2000, Thrombosis research.

[10]  A. Buczyński,et al.  Free radicals are involved in cancer procoagulant-induced platelet activation. , 2000, Thrombosis research.

[11]  P. Feindt,et al.  Markers of activated hemostasis and fibrinolysis in patients with pulmonary malignancies: comparison of plasma levels in central venous and pulmonary venous blood. , 2000, Thrombosis research.

[12]  H. Prydz,et al.  Coagulation Factors VIIa and Xa Induce Cell Signaling Leading to Up-regulation of the egr-1 Gene* , 1999, The Journal of Biological Chemistry.

[13]  P. Rutkowski,et al.  Activation of blood coagulation and the activity of cancer procoagulant (EC 3.4.22.26) in breast cancer patients. , 1999, Cancer letters.

[14]  Y. Miyagi,et al.  Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor. , 1999, The Journal of clinical investigation.

[15]  S. Coughlin,et al.  How the protease thrombin talks to cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[16]  W. Ruf,et al.  Tissue Factor Signaling , 1999, Thrombosis and Haemostasis.

[17]  P. Freskgård,et al.  Factor VIIa-induced p44/42 Mitogen-activated Protein Kinase Activation Requires the Proteolytic Activity of Factor VIIa and Is Independent of the Tissue Factor Cytoplasmic Domain* , 1999, The Journal of Biological Chemistry.

[18]  P. Nawroth,et al.  Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[19]  R. Homer,et al.  Role of Tissue Factor in Metastasis: Functions of the Cytoplasmic and Extracellular Domains of the Molecule , 1999, Thrombosis and Haemostasis.

[20]  X. Cai,et al.  Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents , 1999, Leukemia.

[21]  N. Lemoine,et al.  Role of tissue factor expression on tumour cell invasion and growth of experimental pancreatic adenocarcinoma , 1999, The British journal of surgery.

[22]  B. Wachowicz,et al.  Cancer procoagulant stimulates platelet adhesion. , 1999, Thrombosis research.

[23]  A. Falanga,et al.  Pathophysiology of the Thrombophilic State in the Cancer Patient , 1999, Seminars in thrombosis and hemostasis.

[24]  O. Matsubara,et al.  Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis , 1999, British Journal of Cancer.

[25]  J. Francis,et al.  Urinary tissue factor levels in patients with breast and colorectal cancer , 1999, The Journal of pathology.

[26]  H. Shiku,et al.  Tissue Factor Expression and Metastatic Potential of Colorectal Cancer , 1998, Thrombosis and Haemostasis.

[27]  G. Pineo,et al.  8 Venous thromboembolism and cancer , 1998 .

[28]  T. Barbui,et al.  Cancer procoagulant and tissue factor are differently modulated by all-trans-retinoic acid in acute promyelocytic leukemia cells. , 1998, Blood.

[29]  P. Carmeliet,et al.  Molecules in focus Tissue factor , 1998 .

[30]  S. Bentolila,et al.  Tissue factor-dependent vascular endothelial growth factor production by human fibroblasts in response to activated factor VII. , 1998, Blood.

[31]  M. Kurimoto,et al.  Generation of a monoclonal antibody that inhibits the procoagulant activity of various cancer cell lines , 1998, Cancer.

[32]  J. Biggerstaff,et al.  Hemostasis and Malignancy , 1998, Seminars in thrombosis and hemostasis.

[33]  W. Ruf,et al.  Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. , 1998, The Journal of clinical investigation.

[34]  L. Poulsen,et al.  Signal Transduction via the Mitogen-activated Protein Kinase Pathway Induced by Binding of Coagulation Factor VIIa to Tissue Factor* , 1998, The Journal of Biological Chemistry.

[35]  Y. Miyagi,et al.  A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280 , 1998, The Journal of cell biology.

[36]  Y. Nemerson,et al.  Some thoughts about localization and expression of tissue factor. , 1998, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[37]  U. Pendurthi,et al.  Tissue factor on cells. , 1998, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[38]  W. Ruf.  The interaction of activated factor VII with tissue factor: insight into the mechanism of cofactor-mediated activation of activated factor VII. , 1998, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[39]  B. Østerud.  Tissue factor expression by monocytes: regulation and pathophysiological roles. , 1998 .

[40]  M. Volm,et al.  Tissue‐factor expression in human non‐small‐cell lung carcinoma measured by immunohistochemistry: Correlation between tissue factor and angiogenesis , 1998, International journal of cancer.

[41]  J. Wilcox,et al.  Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer. , 1998, The American journal of pathology.

[42]  U. Pendurthi,et al.  Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: up-regulation of poly(A) polymerase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[43]  C. Moldow,et al.  Mechanism of tissue factor activation on HL-60 cells. , 1997, Blood.

[44]  S. Gordon,et al.  Cancer procoagulant: a factor X activator, tumor marker and growth factor from malignant tissue. , 1997, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[45]  P. Carmeliet,et al.  Role of tissue factor in embryonic blood vessel development , 1996, Nature.

[46]  W. Ruf,et al.  Tissue factor in cancer angiogenesis and metastasis , 1996, Current opinion in hematology.

[47]  R. Silverstein,et al.  Hypercoagulability in cancer. , 1996, Hematology/oncology clinics of North America.

[48]  David W. Banner,et al.  The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor , 1996, Nature.

[49]  W. Konigsberg,et al.  Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[50]  W. Ruf,et al.  Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells. , 1995, Cancer research.

[51]  J. Røttingen,et al.  Binding of Human Factor VIIa to Tissue Factor Induces Cytosolic Ca2+ Signals in J82 Cells, Transfected COS-1 Cells, Madin-Darby Canine Kidney Cells and in Human Endothelial Cells Induced to Synthesize Tissue Factor (*) , 1995, The Journal of Biological Chemistry.

[52]  S. Gordon,et al.  Effect of divalent ions on the activity of cancer procoagulant. , 1994, Archives of biochemistry and biophysics.

[53]  M. Ultsch,et al.  Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. , 1994, Biochemistry.

[54]  T. Luther,et al.  Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. , 1994, The Journal of clinical investigation.

[55]  D. Stuart,et al.  Crystal structure of the extracellular region of human tissue factor , 1994, Nature.

[56]  S. Gordon,et al.  Application of cancer procoagulant as an early detection tumor marker , 1994, Cancer.

[57]  S. Gordon,et al.  New Immunocapture Enzyme (ICE) Assay for Quantification of Cancer Procoagulant Activity: Studies of Inhibitors , 1994, Thrombosis and Haemostasis.

[58]  T S Edgington,et al.  Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[59]  S. Gordon.  Cancer Cell Procoagulants and Their Role in Malignant Disease , 1992, Seminars in thrombosis and hemostasis.

[60]  J. V. Sørensen,et al.  Venous thromboembolism and cancer. , 1992, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[61]  K. Mann,et al.  The evaluation of complex-dependent alterations in human factor VIIa. , 1992, The Journal of biological chemistry.

[62]  S. Gordon,et al.  The site of activation of factor X by cancer procoagulant , 1991, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[63]  K Fujikawa,et al.  The coagulation cascade: initiation, maintenance, and regulation. , 1991, Biochemistry.

[64]  I. Fidler,et al.  Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor. , 1991, Cancer research.

[65]  A. Barrett,et al.  Clostripain: Characterization of the active site , 1991, FEBS letters.

[66]  D. Connolly,et al.  Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration , 1990, The Journal of experimental medicine.

[67]  S. Gordon,et al.  An enzyme-linked immunosorbent assay for cancer procoagulant and its potential as a new tumor marker. , 1990, Cancer research.

[68]  J. Bazan,et al.  Structural design and molecular evolution of a cytokine receptor superfamily. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[69]  R. Bertina,et al.  The contributions of Ca2+, phospholipids and tissue-factor apoprotein to the activation of human blood-coagulation factor X by activated factor VII. , 1990, The Biochemical journal.

[70]  T. Edgington,et al.  Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade , 1987, Cell.

[71]  A. Falanga,et al.  Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue. , 1985, Biochemistry.

[72]  S. Gordon,et al.  A factor X-activating cysteine protease from malignant tissue. , 1981, The Journal of clinical investigation.

[73]  S. Gordon,et al.  Comparison of procoagulant activities in extracts of normal and malignant human tissue. , 1979, Journal of the National Cancer Institute.

[74]  Yu. Pogoreltsev,et al.  The Application , 2020, How to Succeed in the Academic Clinical Interview.

[75]  H. Verheul,et al.  Platelet and coagulation activation with vascular endothelial growth factor generation in soft tissue sarcomas. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[76]  B. Osterud.  Tissue factor expression by monocytes: regulation and pathophysiological roles. , 1998, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[77]  R. Bach.  Mechanism of tissue factor activation on cells. , 1998, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[78]  Roche ResearchCenter,et al.  Vascular Permeability Factor: A Tumor-derived Polypeptide that Induces Endothelial Cell and Monocyte Procoagulant Activity, and Promotes Monocyte Migration , 1990 .

[79]  A. Falanga,et al.  Cysteine proteinase procoagulant from amnion-chorion. , 1985, Blood.

[80]  A. Barrett,et al.  L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. , 1982, The Biochemical journal.