HIV-1-derived lentiviral vectors.

[1]  A. Consiglio,et al.  In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice , 2001, Nature Medicine.

[2]  J. Bloch,et al.  Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. , 2000, Science.

[3]  B. Carlson,et al.  Association of Human Immunodeficiency Virus Type 1 Vif with RNA and Its Role in Reverse Transcription , 2000, Journal of Virology.

[4]  L. Naldini,et al.  Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy , 2000, The journal of gene medicine.

[5]  R. Morgan,et al.  Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins. , 2000, Blood.

[6]  M. Kay,et al.  Therapeutic levels of human factor VIII and IX using HIV-1-based lentiviral vectors in mouse liver. , 2000, Blood.

[7]  Michel Sadelain,et al.  Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin , 2000, Nature.

[8]  J. Ridet,et al.  Lentiviral Vectors as a Gene Delivery System in the Mouse Midbrain: Cellular and Behavioral Improvements in a 6-OHDA Model of Parkinson's Disease Using GDNF , 2000, Experimental Neurology.

[9]  J. Dick,et al.  Transduction of human CD34+ CD38- bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

[10]  L. Ailles,et al.  Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences , 2000, Nature Genetics.

[11]  M. Stevenson.  HIV nuclear import: What's the flap? , 2000, Nature Medicine.

[12]  D. Trono,et al.  Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer. , 2000, Human gene therapy.

[13]  Luc Montagnier,et al.  HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap , 2000, Cell.

[14]  Eithne Costello,et al.  Gene transfer into stimulated and unstimulated T lymphocytes by HIV-1-derived lentiviral vectors , 2000, Gene Therapy.

[15]  Mary Schaefer,et al.  Increased Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 gag Gene , 2000, Journal of Virology.

[16]  J. Bloch,et al.  Lentiviral Gene Transfer to the Nonhuman Primate Brain , 1999, Experimental Neurology.

[17]  M. Bukrinsky,et al.  HIV-1 nuclear import: in search of a leader. , 1999, Frontiers in bioscience : a journal and virtual library.

[18]  M. Federico,et al.  Lentiviruses as gene delivery vectors. , 1999, Current opinion in biotechnology.

[19]  F. Gage,et al.  Rescue from Photoreceptor Degeneration in therd Mouse by Human Immunodeficiency Virus Vector-Mediated Gene Transfer , 1999, Journal of Virology.

[20]  J. Olsen,et al.  Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[21]  L. Naldini,et al.  Interaction of Human Immunodeficiency Virus-Derived Vectors with Wild-Type Virus in Transduced Cells , 1999, Journal of Virology.

[22]  Y. Korin,et al.  Nonproductive Human Immunodeficiency Virus Type 1 Infection in Nucleoside-Treated G0 Lymphocytes , 1999, Journal of Virology.

[23]  D. Littman,et al.  Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes , 1999, The Journal of experimental medicine.

[24]  F. Mavilio,et al.  Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells. , 1999, Blood.

[25]  T. Hope,et al.  Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral Vectors , 1999, Journal of Virology.

[26]  S. Bartz,et al.  Human Immunodeficiency Virus Type 1 Tat Induces Apoptosis and Increases Sensitivity to Apoptotic Signals by Up-Regulating FLICE/Caspase-8 , 1999, Journal of Virology.

[27]  J. Yee,et al.  Requirements for Efficient Production and Transduction of Human Immunodeficiency Virus Type 1-Based Vectors , 1999, Journal of Virology.

[28]  B. Torbett,et al.  Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. , 1999, Science.

[29]  N. Sarvetnick,et al.  Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. , 1998, Human gene therapy.

[30]  D. Trono,et al.  Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery , 1998, Journal of Virology.

[31]  Navid Madani,et al.  An Endogenous Inhibitor of Human Immunodeficiency Virus in Human Lymphocytes Is Overcome by the Viral Vif Protein , 1998, Journal of Virology.

[32]  G. Nolan,et al.  Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells , 1998, Cell.

[33]  D. Trono,et al.  A Third-Generation Lentivirus Vector with a Conditional Packaging System , 1998, Journal of Virology.

[34]  L. Naldini.  Lentiviruses as gene transfer agents for delivery to non-dividing cells. , 1998, Current opinion in biotechnology.

[35]  Fred H. Gage,et al.  Development of a Self-Inactivating Lentivirus Vector , 1998, Journal of Virology.

[36]  E. Poeschla,et al.  Identification of a Human Immunodeficiency Virus Type 2 (HIV-2) Encapsidation Determinant and Transduction of Nondividing Human Cells by HIV-2-Based Lentivirus Vectors , 1998, Journal of Virology.

[37]  M. Malim,et al.  Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex , 1998, Journal of Virology.

[38]  M. Malim,et al.  HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. , 1998, Science.

[39]  J. Sodroski,et al.  The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens. , 1998, Science.

[40]  S. Arya,et al.  Human immunodeficiency virus type 2 lentivirus vectors for gene transfer: expression and potential for helper virus-free packaging. , 1998, Human gene therapy.

[41]  B. Cullen.  HIV-1 Auxiliary Proteins: Making Connections in a Dying Cell , 1998, Cell.

[42]  Y. Korin,et al.  Progression to the G1b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells , 1998, Journal of Virology.

[43]  W. Sundquist,et al.  Proteolytic refolding of the HIV‐1 capsid protein amino‐terminus facilitates viral core assembly , 1998, The EMBO journal.

[44]  J. Yewdell,et al.  CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway , 1998, Journal of Virology.

[45]  G. Blobel,et al.  Viral protein R regulates nuclear import of the HIV‐1 pre‐integration complex , 1998, The EMBO journal.

[46]  P. Silver,et al.  HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. , 1998, Genes & development.

[47]  A. Kingsman,et al.  Minimal Requirement for a Lentivirus Vector Based on Human Immunodeficiency Virus Type 1 , 1998, Journal of Virology.

[48]  S. Cole,et al.  Reduced viral load and lack of CD4 depletion in SCID-hu mice infected with Rev-independent clones of human immunodeficiency virus type 1 , 1997, Journal of virology.

[49]  D. Peterson,et al.  Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors , 1997, Nature Genetics.

[50]  M. Rosbash,et al.  The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export , 1997, Current Biology.

[51]  F. Gage,et al.  Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[52]  T. Hope,et al.  HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[53]  L Naldini,et al.  Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector , 1997, Journal of virology.

[54]  S. Zolla-Pazner,et al.  Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor , 1997, Journal of virology.

[55]  Luigi Naldini,et al.  Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo , 1997, Nature Biotechnology.

[56]  C. Aiken.  Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A , 1997, Journal of virology.

[57]  S. Bartz,et al.  Production of high-titer human immunodeficiency virus type 1 pseudotyped with vesicular stomatitis virus glycoprotein. , 1997, Methods.

[58]  D. Littman,et al.  Expression cloning of new receptors used by simian and human immunodeficiency viruses , 1997, Nature.

[59]  R. Weiss,et al.  Immunodeficiency viruses: Spoilt for choice of co-receptors , 1997, Nature.

[60]  G. Pavlakis,et al.  Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation , 1997, Journal of virology.

[61]  É. Cohen,et al.  Putative alpha-helical structures in the human immunodeficiency virus type 1 Vpu protein and CD4 are involved in binding and degradation of the CD4 molecule , 1997, Journal of virology.

[62]  J. Binley,et al.  The viral mousetrap , 1997, Nature.

[63]  T. Parslow,et al.  Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation , 1997, Journal of virology.

[64]  J. Yewdell,et al.  The Human Immunodeficiency Virus Type 1 (HIV-1) Vpu Protein Interferes with an Early Step in the Biosynthesis of Major Histocompatibility Complex (MHC) Class I Molecules , 1997, The Journal of experimental medicine.

[65]  R. Lamb,et al.  Do Vpu and Vpr of human immunodeficiency virus type 1 and NB of influenza B virus have ion channel activities in the viral life cycles? , 1997, Virology.

[66]  E. Poeschla,et al.  Development of HIV vectors for anti-HIV gene therapy. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[67]  F. Gage,et al.  Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[68]  M. Malim,et al.  The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes , 1996, Journal of virology.

[69]  R. Gorelick,et al.  HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[70]  Stephen C. Peiper,et al.  Identification of a major co-receptor for primary isolates of HIV-1 , 1996, Nature.

[71]  Paul E. Kennedy,et al.  HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor , 1996, Science.

[72]  F. Gage,et al.  In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector , 1996, Science.

[73]  W. Sundquist,et al.  Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[74]  D. Trono,et al.  Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import , 1996, Journal of virology.

[75]  H. Göttlinger,et al.  A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 Vpr , 1996, Journal of virology.

[76]  D O Morgan,et al.  Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity , 1995, Journal of virology.

[77]  D. Trono,et al.  Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis , 1995, Journal of virology.

[78]  O. Danos,et al.  Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell , 1995, Journal of virology.

[79]  I. Thior,et al.  Reduced rate of disease development after HIV-2 infection as compared to HIV-1. , 1994, Science.

[80]  H. Buc,et al.  HIV-1 reverse transcription. A termination step at the center of the genome. , 1994, Journal of molecular biology.

[81]  C. Parolin,et al.  Analysis in human immunodeficiency virus type 1 vectors of cis-acting sequences that affect gene transfer into human lymphocytes , 1994, Journal of virology.

[82]  E. Freed,et al.  HIV-1 infection of non-dividing cells , 1994, Nature.

[83]  I. Thior,et al.  Slower heterosexual spread of HIV-2 than HIV-1 , 1994, The Lancet.

[84]  J. Rousset,et al.  Translational frameshifting at the gag-pol junction of human immunodeficiency virus type 1 is not increased in infected T-lymphoid cells , 1994, Journal of virology.

[85]  M. Emerman,et al.  Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus , 1994, Journal of virology.

[86]  M. Emerman,et al.  A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells , 1993, Nature.

[87]  T Friedmann,et al.  Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[88]  P. Brown,et al.  Integration of murine leukemia virus DNA depends on mitosis. , 1993, The EMBO journal.

[89]  M. Martin,et al.  Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4 , 1992, Journal of virology.

[90]  M. Bukrinsky,et al.  Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[91]  J. Zack,et al.  Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle , 1992, Journal of virology.

[92]  M. Malim,et al.  Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes , 1991, The Journal of experimental medicine.

[93]  D. Littman,et al.  Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range , 1991, Journal of virology.

[94]  D. Littman,et al.  Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity , 1990, Journal of virology.

[95]  A. Miller,et al.  Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection , 1990, Molecular and cellular biology.

[96]  Jerome A. Zack,et al.  HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure , 1990, Cell.

[97]  S. Le,et al.  The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA , 1989, Nature.

[98]  M. Emerman.  Learning from lentiviruses , 2000, Nature genetics.

[99]  Y. Arsenijévic,et al.  Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. , 2000, Human gene therapy.

[100]  M. Nowak,et al.  HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo , 1998, Nature Medicine.

[101]  F. Wong-Staal,et al.  Transduction of human macrophages using a stable HIV-1/HIV-2-derived gene delivery system , 1998, Gene Therapy.

[102]  A. Frankel,et al.  HIV-1: fifteen proteins and an RNA. , 1998, Annual review of biochemistry.

[103]  M. Foti,et al.  The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane. , 1997, Immunity.

[104]  D. Trono,et al.  The multifaceted role of HIV Nef. , 1997, Research in virology.

[105]  A. Skalka,et al.  The retroviral enzymes. , 1994, Annual review of biochemistry.

[106]  M. Greaves,et al.  The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus , 1984, Nature.