Global Trends in CD4 Cell Count at the Start of Antiretroviral Therapy: Collaborative Study of Treatment Programs

We modeled global time trends in median CD4 cell counts at combination antiretroviral therapy initiation in human immunodeficiency virus–infected adults. These counts have increased in all country income groups since 2002 but generally remained below 350/μL in 2015.

[1]  A. Abdul-Quader,et al.  Trends in Prevalence of Advanced HIV Disease at Antiretroviral Therapy Enrollment — 10 Countries, 2004–2015 , 2017, MMWR. Morbidity and mortality weekly report.

[2]  J. Sterne,et al.  Cohort Profile: Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. , 2016, International journal of epidemiology.

[3]  Jennifer F Hoy,et al.  Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel. , 2016, JAMA.

[4]  N. Medina,et al.  Is Expanded HIV Testing Associated with Earlier HIV Diagnosis? Results from an HIV Clinic in Guatemala City , 2016, Journal of the International Association of Providers of AIDS Care.

[5]  Lena Osterhagen,et al.  Multiple Imputation For Nonresponse In Surveys , 2016 .

[6]  S. Essajee,et al.  HIV and the Millennium Development Goals , 2015, Archives of Disease in Childhood.

[7]  K. Anastos,et al.  Trends in and correlates of CD4+ cell count at antiretroviral therapy initiation after changes in national ART guidelines in Rwanda , 2015, AIDS.

[8]  I. Bassett,et al.  Trends in CD4 count at presentation to care and treatment initiation in sub-Saharan Africa, 2002-2013: a meta-analysis. , 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  R. Remien,et al.  Advanced HIV disease at entry into HIV care and initiation of antiretroviral therapy during 2006-2011: findings from four sub-saharan African countries. , 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[10]  B. Chi,et al.  Immunodeficiency at the Start of Combination Antiretroviral Therapy in Low-, Middle-, and High-Income Countries , 2013, Journal of acquired immune deficiency syndromes.

[11]  S. Cole,et al.  A systematic review and meta-regression of temporal trends in adult CD4(+) cell count at presentation to HIV care, 1992-2011. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  Anne M Johnson,et al.  Risk Factors and Outcomes for Late Presentation for HIV-Positive Persons in Europe: Results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE) , 2013, PLoS medicine.

[13]  Kara Wools-Kaloustian,et al.  Cohort Profile: the international epidemiological databases to evaluate AIDS (IeDEA) in sub-Saharan Africa. , 2012, International journal of epidemiology.

[14]  N. Mugo,et al.  “What Took You So Long?” The Impact of PEPFAR on the Expansion of HIV Testing and Counseling Services in Africa , 2012, Journal of acquired immune deficiency syndromes.

[15]  Huldrych F. Günthard,et al.  Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. , 2012, JAMA.

[16]  T. Coates,et al.  Missed Opportunities for HIV Testing and Late-Stage Diagnosis among HIV-Infected Patients in Uganda , 2011, PloS one.

[17]  Amalio Telenti,et al.  Antiretroviral Treatment of Adult HIV Infection2010 Recommendations of the International AIDS Society–USA Panel , 2010 .

[18]  Douglas D. Richman,et al.  Antiretroviral Treatment of Adult HIV Infection , 2008 .

[19]  D. Masys,et al.  Cohort Profile: Caribbean, Central and South America Network for HIV research (CCASAnet) collaboration within the International Epidemiologic Databases to Evaluate AIDS (IeDEA) programme. , 2007, International journal of epidemiology.

[20]  G. Dore,et al.  Hepatitis B and C virus coinfection in The TREAT Asia HIV Observational Database , 2007, Journal of gastroenterology and hepatology.

[21]  Richard D Moore,et al.  Cohort profile: the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). , 2007, International journal of epidemiology.

[22]  C. Gilks,et al.  National adult antiretroviral therapy guidelines in resource-limited countries: concordance with 2003 WHO guidelines? , 2006, AIDS.

[23]  B. Stilwell,et al.  Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. 2006 revision. , 2006 .

[24]  A. Vibhagool,et al.  The TREAT Asia HIV Observational Database: Baseline and Retrospective Data , 2005, Journal of acquired immune deficiency syndromes.

[25]  James Curran,et al.  Scaling Up Antiretroviral Therapy in Resource-Limited Settings: Treatment Guidelines for a Public Health Approach , 2005 .

[26]  N. Michael,et al.  Joint United Nations Programme on HIV/AIDS. , 2004, Military medicine.

[27]  Peter Piot,et al.  Joint United Nations Program on HIV/AIDS (UNAIDS) , 1997 .

[28]  I. Chalmers.  The Cochrane Collaboration: Preparing, Maintaining, and Disseminating Systematic Reviews of the Effects of Health Care , 1993, Annals of the New York Academy of Sciences.

[29]  C. Sabin,et al.  Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV‐1 diagnosis , 1992, Clinical and experimental immunology.